JPS56131599A - Methylated prostaglandin derivative - Google Patents

Methylated prostaglandin derivative

Info

Publication number
JPS56131599A
JPS56131599A JP3508680A JP3508680A JPS56131599A JP S56131599 A JPS56131599 A JP S56131599A JP 3508680 A JP3508680 A JP 3508680A JP 3508680 A JP3508680 A JP 3508680A JP S56131599 A JPS56131599 A JP S56131599A
Authority
JP
Japan
Prior art keywords
formula
group
compound
prostaglandin derivative
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3508680A
Other languages
Japanese (ja)
Other versions
JPS611079B2 (en
Inventor
Satoshi Enomoto
Yoshiro Asano
Fumio Tamura
Hiromitsu Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kureha Corp
Original Assignee
Kureha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Corp filed Critical Kureha Corp
Priority to JP3508680A priority Critical patent/JPS56131599A/en
Priority to US06/153,415 priority patent/US4318908A/en
Priority to AU64215/80A priority patent/AU537762B2/en
Priority to AT80107209T priority patent/ATE11283T1/en
Priority to DE8080107209T priority patent/DE3069990D1/en
Priority to EP80107209A priority patent/EP0030299B1/en
Priority to DK516880A priority patent/DK160830C/en
Priority to CA000366198A priority patent/CA1159821A/en
Publication of JPS56131599A publication Critical patent/JPS56131599A/en
Publication of JPS611079B2 publication Critical patent/JPS611079B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

NEW MATERIAL:A methylated prostaglandin derivative (Me-PG) of formula I [PG is group of formula II (R1 is H, acetyl, etc.); St is group of formula III IV (R is acetyl, propionyl, etc.); n is 1,2 or 3; m is 0 or 1].
EXAMPLE: 3-Hydroxy-1,3,5(10)-estratriene-17β-oxycarbonylmethyl 16, 16-dimethyl- 11α, 15α-diacetoxy-9-oxo-2(trans)-13(trans)-prostadienoate.
USE: Usable for criminal abortion, delivery induction, etc. with low toxicity and side effects, e.g. diarrhea.
PROCESS: A compound of the formula X(CH2)nCOY [X is halogen; Y is halogen or OH] is reacted with the OH group at the 17-position in estradiol to give a compound of the formula X(CH2)nCOOB (B is group in which the OH group at the 17- position is removed), which is then reacted with a carboxylic acid group of the Me- PG to afford the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP3508680A 1979-12-06 1980-03-19 Methylated prostaglandin derivative Granted JPS56131599A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP3508680A JPS56131599A (en) 1980-03-19 1980-03-19 Methylated prostaglandin derivative
US06/153,415 US4318908A (en) 1979-12-06 1980-05-27 Methylated prostaglandin derivatives
AU64215/80A AU537762B2 (en) 1979-12-06 1980-11-10 Prostaglandin esters of steroids
AT80107209T ATE11283T1 (en) 1979-12-06 1980-11-19 STEROID ESTERS OF METHYLATED PROSTAGLANDIN DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS.
DE8080107209T DE3069990D1 (en) 1979-12-06 1980-11-19 Steroid esters of methylated prostaglandin derivatives and their pharmaceutical compositions
EP80107209A EP0030299B1 (en) 1979-12-06 1980-11-19 Steroid esters of methylated prostaglandin derivatives and their pharmaceutical compositions
DK516880A DK160830C (en) 1979-12-06 1980-12-03 METHYLERED PROSTAGLANDIN STEROID HORMOND DERIVATIVES AND ABORTIVE AGENTS CONTAINING SAME
CA000366198A CA1159821A (en) 1979-12-06 1980-12-05 Methylated prostaglandin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3508680A JPS56131599A (en) 1980-03-19 1980-03-19 Methylated prostaglandin derivative

Publications (2)

Publication Number Publication Date
JPS56131599A true JPS56131599A (en) 1981-10-15
JPS611079B2 JPS611079B2 (en) 1986-01-13

Family

ID=12432147

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3508680A Granted JPS56131599A (en) 1979-12-06 1980-03-19 Methylated prostaglandin derivative

Country Status (1)

Country Link
JP (1) JPS56131599A (en)

Also Published As

Publication number Publication date
JPS611079B2 (en) 1986-01-13

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