JPS5677265A - Novel quinazoline derivative - Google Patents
Novel quinazoline derivativeInfo
- Publication number
- JPS5677265A JPS5677265A JP15291079A JP15291079A JPS5677265A JP S5677265 A JPS5677265 A JP S5677265A JP 15291079 A JP15291079 A JP 15291079A JP 15291079 A JP15291079 A JP 15291079A JP S5677265 A JPS5677265 A JP S5677265A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- hypertension
- quinazoline derivative
- dimethoxyquinazoline
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- 206010020772 Hypertension Diseases 0.000 abstract 2
- LWEWMCLJACLWLE-UHFFFAOYSA-N 4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-n-phenylpiperazine-1-carboxamide Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)NC1=CC=CC=C1 LWEWMCLJACLWLE-UHFFFAOYSA-N 0.000 abstract 1
- APKHJGDGWQDBGM-UHFFFAOYSA-N 6,7-dimethoxy-2-piperazin-1-ylquinazolin-4-amine Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N1CCNCC1 APKHJGDGWQDBGM-UHFFFAOYSA-N 0.000 abstract 1
- 208000007530 Essential hypertension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001919 adrenal effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 201000005857 malignant hypertension Diseases 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003246 quinazolines Chemical class 0.000 abstract 1
- 206010038464 renal hypertension Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15291079A JPS5677265A (en) | 1979-11-28 | 1979-11-28 | Novel quinazoline derivative |
| US06/199,565 US4607034A (en) | 1979-10-29 | 1980-10-21 | Quinazoline derivatives and pharmaceutical composition thereof |
| CA000363320A CA1141378A (en) | 1979-10-29 | 1980-10-27 | Quinazoline derivatives |
| EP80106648A EP0028031B1 (en) | 1979-10-29 | 1980-10-29 | Novel quinazoline derivatives, a pharmaceutical composition containing such derivatives as active ingredient and a process for producing the quinazoline derivatives |
| DE8080106648T DE3064773D1 (en) | 1979-10-29 | 1980-10-29 | Novel quinazoline derivatives, a pharmaceutical composition containing such derivatives as active ingredient and a process for producing the quinazoline derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15291079A JPS5677265A (en) | 1979-11-28 | 1979-11-28 | Novel quinazoline derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5677265A true JPS5677265A (en) | 1981-06-25 |
| JPS6313992B2 JPS6313992B2 (enExample) | 1988-03-29 |
Family
ID=15550805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15291079A Granted JPS5677265A (en) | 1979-10-29 | 1979-11-28 | Novel quinazoline derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5677265A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004513126A (ja) * | 2000-11-01 | 2004-04-30 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法 |
-
1979
- 1979-11-28 JP JP15291079A patent/JPS5677265A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004513126A (ja) * | 2000-11-01 | 2004-04-30 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6313992B2 (enExample) | 1988-03-29 |
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