JPS5663979A - Novel vinyl ether derivative and its preparation - Google Patents

Novel vinyl ether derivative and its preparation

Info

Publication number
JPS5663979A
JPS5663979A JP13938579A JP13938579A JPS5663979A JP S5663979 A JPS5663979 A JP S5663979A JP 13938579 A JP13938579 A JP 13938579A JP 13938579 A JP13938579 A JP 13938579A JP S5663979 A JPS5663979 A JP S5663979A
Authority
JP
Japan
Prior art keywords
compound
formula
preparation
vinyl ether
prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13938579A
Other languages
Japanese (ja)
Other versions
JPS6345385B2 (en
Inventor
Toshio Tanaka
Takeshi Yu
Takeo Oba
Noriaki Okamura
Kenzo Watanabe
Kiyoshi Sakauchi
Seiji Kurozumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP13938579A priority Critical patent/JPS5663979A/en
Publication of JPS5663979A publication Critical patent/JPS5663979A/en
Publication of JPS6345385B2 publication Critical patent/JPS6345385B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R 1 and R2 are H or protecting group; Y is H; X is halogen, or X and Y together form a C-C bond).
EXAMPLE: 1,2,3,4-Tetranor-prostaglandin I2.
USE: An intermediate for the production of a prostaglandin I2 analogue having blood platelet coagulation inhibiting, coagulated platelet dissolving, arterial duct relaxing, and hypotensive activities, etc.
PROCESS: A compound of formula I wherein Y is H and X is halogen is prepared by the halogenative cyclization of a compound of formula II with a reaction reagent such as N-bromosuccinimide, etc. The compound thus prepared is converted to another compound of formula I wherein X and Y together form a C-C bond by reacting with an organic base, e.g. 1,5-diazabicyclo[5,4,0]undecene-5, in an organic solvent such as benzene at 0W150°C, and subjecting the product to dehydrohalogenation reaction.
COPYRIGHT: (C)1981,JPO&Japio
JP13938579A 1979-10-30 1979-10-30 Novel vinyl ether derivative and its preparation Granted JPS5663979A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13938579A JPS5663979A (en) 1979-10-30 1979-10-30 Novel vinyl ether derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13938579A JPS5663979A (en) 1979-10-30 1979-10-30 Novel vinyl ether derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5663979A true JPS5663979A (en) 1981-05-30
JPS6345385B2 JPS6345385B2 (en) 1988-09-09

Family

ID=15244073

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13938579A Granted JPS5663979A (en) 1979-10-30 1979-10-30 Novel vinyl ether derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5663979A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10100028B2 (en) 2013-09-30 2018-10-16 Patheon Api Services Inc. Synthesis routes for prostaglandins and prostaglandin intermediates using metathesis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10100028B2 (en) 2013-09-30 2018-10-16 Patheon Api Services Inc. Synthesis routes for prostaglandins and prostaglandin intermediates using metathesis

Also Published As

Publication number Publication date
JPS6345385B2 (en) 1988-09-09

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