JPS5657718A - Preparation of s-sulfonated immunoglobulin containing large amount of monomer - Google Patents
Preparation of s-sulfonated immunoglobulin containing large amount of monomerInfo
- Publication number
- JPS5657718A JPS5657718A JP13278679A JP13278679A JPS5657718A JP S5657718 A JPS5657718 A JP S5657718A JP 13278679 A JP13278679 A JP 13278679A JP 13278679 A JP13278679 A JP 13278679A JP S5657718 A JPS5657718 A JP S5657718A
- Authority
- JP
- Japan
- Prior art keywords
- basic
- organic compound
- immunoglobulin
- sulfonated
- large amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 4
- 102000018358 immunoglobulin Human genes 0.000 title abstract 4
- 239000000178 monomer Substances 0.000 title 1
- -1 arginine Chemical class 0.000 abstract 3
- 150000002894 organic compounds Chemical class 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 238000010494 dissociation reaction Methods 0.000 abstract 2
- 230000005593 dissociations Effects 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 102000006395 Globulins Human genes 0.000 abstract 1
- 108010044091 Globulins Proteins 0.000 abstract 1
- FORGMRSGVSYZQR-YFKPBYRVSA-N L-leucinamide Chemical compound CC(C)C[C@H](N)C(N)=O FORGMRSGVSYZQR-YFKPBYRVSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 1
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000009257 reactivity Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 abstract 1
- 238000006277 sulfonation reaction Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13278679A JPS5657718A (en) | 1979-10-17 | 1979-10-17 | Preparation of s-sulfonated immunoglobulin containing large amount of monomer |
| US06/182,053 US4360457A (en) | 1979-08-30 | 1980-08-28 | S-Sulfonated immunoglobulin composition having a high monomer content and a process for production thereof |
| CA000359215A CA1153695A (en) | 1979-08-30 | 1980-08-28 | S-sulfonated immunoglobulin composition having a high monomer content and a process for production thereof |
| AT80303004T ATE6740T1 (de) | 1979-08-30 | 1980-08-29 | Zusammensetzung, die ein s-sulfoniertes immunoglobulin und ein eine zusammenballung verhuetendes oder eine zusammenballung dissoziierendes mittel enthaelt, und verfahren zur herstellung von zusammensetzungen, die einen hohen anteil monomeren s-sulfonierten immunoglobulins enthalten. |
| DE8080303004T DE3067150D1 (en) | 1979-08-30 | 1980-08-29 | Composition containing s-sulfonated immunoglobulin and aggregation preventing or aggregate dissociating agent therefor, and processes for preparing compositions containing high proportions of monomeric s-sulfonated immunoglobulin |
| EP80303004A EP0025321B1 (en) | 1979-08-30 | 1980-08-29 | Composition containing s-sulfonated immunoglobulin and aggregation preventing or aggregate dissociating agent therefor, and processes for preparing compositions containing high proportions of monomeric s-sulfonated immunoglobulin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13278679A JPS5657718A (en) | 1979-10-17 | 1979-10-17 | Preparation of s-sulfonated immunoglobulin containing large amount of monomer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5657718A true JPS5657718A (en) | 1981-05-20 |
| JPS6155895B2 JPS6155895B2 (enrdf_load_stackoverflow) | 1986-11-29 |
Family
ID=15089503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13278679A Granted JPS5657718A (en) | 1979-08-30 | 1979-10-17 | Preparation of s-sulfonated immunoglobulin containing large amount of monomer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5657718A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5485489B2 (ja) * | 2000-08-11 | 2014-05-07 | 中外製薬株式会社 | 抗体含有安定化製剤 |
| JP2014105180A (ja) * | 2012-11-27 | 2014-06-09 | Hoya Corp | モノマー化方法 |
-
1979
- 1979-10-17 JP JP13278679A patent/JPS5657718A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5485489B2 (ja) * | 2000-08-11 | 2014-05-07 | 中外製薬株式会社 | 抗体含有安定化製剤 |
| JP2014105180A (ja) * | 2012-11-27 | 2014-06-09 | Hoya Corp | モノマー化方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6155895B2 (enrdf_load_stackoverflow) | 1986-11-29 |
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