JPS5467025A - Preparation of immue gamma-globlin derivative - Google Patents
Preparation of immue gamma-globlin derivativeInfo
- Publication number
- JPS5467025A JPS5467025A JP13256777A JP13256777A JPS5467025A JP S5467025 A JPS5467025 A JP S5467025A JP 13256777 A JP13256777 A JP 13256777A JP 13256777 A JP13256777 A JP 13256777A JP S5467025 A JPS5467025 A JP S5467025A
- Authority
- JP
- Japan
- Prior art keywords
- bond
- globulin
- pref
- moles
- trithionate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
PURPOSE: To prepare immune gamma-globulin derivative which can be administered by intravenous injection, and having low anticomplimentary titer, by reacting human immune globulin with trithionic aid salt and sulfurous acid (salt) in water, thereby breaking the interchain S-S bond, and at the same time, sulfonating the S atom.
CONSTITUTION: Human immune gamma-globulin is made to react with a trithionate- ion-producing substance (e.g. sodium trithionate) and a sulfite-ion-producing substance (e.g. sulfurous acid (salt)). The interchain S-S bond of the immune globulin is broken, and at the same time, the S atom is sulfonated, thereby converting the S-S bond to S-sulfonate group (-S-SO3-). After the reaction, it is purified by dialysis salting out, column chromatography, etc. to obtain the purified objective compound. The amounts of the sulfite and the trithionate is ≥ 2 moles, pref. ≥ 10 moles, and ≥ 1 mole, pref. ≥ 2 moles, per 1 mole of S-S bond, respectively. The reaction is carried out at pH6W10, and 50°C, pref. 10W45°C, for 0.5W24 hours.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13256777A JPS5467025A (en) | 1977-11-07 | 1977-11-07 | Preparation of immue gamma-globlin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13256777A JPS5467025A (en) | 1977-11-07 | 1977-11-07 | Preparation of immue gamma-globlin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5467025A true JPS5467025A (en) | 1979-05-30 |
JPS6139930B2 JPS6139930B2 (en) | 1986-09-06 |
Family
ID=15084314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13256777A Granted JPS5467025A (en) | 1977-11-07 | 1977-11-07 | Preparation of immue gamma-globlin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5467025A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0644671U (en) * | 1991-02-13 | 1994-06-14 | 株式会社バンガード | Support release device in a portable carrier |
JPH07165083A (en) * | 1993-12-16 | 1995-06-27 | Murata Mach Ltd | Hand truck |
-
1977
- 1977-11-07 JP JP13256777A patent/JPS5467025A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6139930B2 (en) | 1986-09-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS525800A (en) | Method of purifying stevioside | |
JPS56163456A (en) | Preparation of antigen | |
JPS5467025A (en) | Preparation of immue gamma-globlin derivative | |
JPS51146432A (en) | Process for preparation of benzanilide derivatives having therapeutic action to immunological disease | |
DK155020C (en) | PROCEDURE FOR RECOVERING MOLYBDA IN THE FORM OF Aqueous SOLUTION OF PURE MOLYBDAIC ACID FROM MOLYBDA-CONTAINING CATALYSTS | |
JPS542396A (en) | Purification of urokinase | |
JPS51115402A (en) | Process for preparation of alpha-amino acid | |
JPS5214721A (en) | Process for preparation of sodium malate hydrate | |
JPS53127808A (en) | Preparation of human albumin | |
JPS5223037A (en) | Process for preparation of optical active amino acid | |
ES8405370A1 (en) | A procedure for preparing pirrolidine-derived diasterisomers (Machine-translation by Google Translate, not legally binding) | |
JPS53133621A (en) | Preparation of basic amino acid acetylsalicylate crystals | |
JPS55122786A (en) | Ephedrazine compound and its preparation | |
JPS5239670A (en) | Process for synthesizing motilin | |
JPS5657718A (en) | Preparation of s-sulfonated immunoglobulin containing large amount of monomer | |
DK37882A (en) | PROCESS FOR THE PREPARATION OF ((1-BENZYL-1H-INDAZOL-3-YL) OXY) ACETIC ACID SALT WITH LYSINE | |
JPS55167274A (en) | Forphenicine derivative and its preparation | |
JPS5273888A (en) | Preparation of gamma-glutamic acid-n-carboxylic acid | |
JPS51149222A (en) | Preparation of highly purified leucine | |
JPS5382718A (en) | Purification of decance-1,10-dicarboxylic acid or its ester | |
DK391482A (en) | PROCEDURE FOR PREPARING PURE 6,6-DIIODPENICILLANIC ACID BY DIAZOTING 6BETA-AMINOPENICILLANIC ACID IN THE PRESENT OF IOD | |
JPS52144642A (en) | Preparation of 3-chloro-4-allyloxyphenylacetic acid | |
JPS5318521A (en) | Preparation of 3,5-dichloronitrogenzene | |
JPS5289684A (en) | Preparation of triesters of isocyanuric acid | |
JPS5253812A (en) | Preparation of perfluorocarboxylic acid |