JPS565486A - Cephalosporin derivative and its salt - Google Patents

Cephalosporin derivative and its salt

Info

Publication number
JPS565486A
JPS565486A JP8170379A JP8170379A JPS565486A JP S565486 A JPS565486 A JP S565486A JP 8170379 A JP8170379 A JP 8170379A JP 8170379 A JP8170379 A JP 8170379A JP S565486 A JPS565486 A JP S565486A
Authority
JP
Japan
Prior art keywords
formula
salt
derivative
cephalosporin
formyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8170379A
Other languages
Japanese (ja)
Inventor
Junji Nakano
Toshio Furumiya
Yoshiyuki Takase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP8170379A priority Critical patent/JPS565486A/en
Publication of JPS565486A publication Critical patent/JPS565486A/en
Pending legal-status Critical Current

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Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A cephalosporin derivative of formula I (R is formyl or acetyl group; R' is acetoxy group, etc.), and its salt.
EXAMPLE: 7-[ D-α-[ 1,4-Dihydro-6-fluoro-7-( 4-formyl-1-piperazinyl )-4-oxoquinoline-3-carboxamido ]-α-p-hydroxyphenylacetamido ]-3-( 1-carboxymethyltetrazol-5- yl)-thiomethyl-3-cephem-4-carboxylic acid sodium salt.
USE: An antimicrobial and its intermediate effective against Gram-positive and Gram- negative bacteria, particularly Pseudomonas aeruginosa, with low toxicity and high solubility.
PROCESS: A carboxylic acid of formula II or its reactive derivative at the carboxyl group, e.g. an acid halide or azide, is reacted with a cephalosporin or its derivative, e.g. sodium salt or trimethylsilyl ester, to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP8170379A 1979-06-27 1979-06-27 Cephalosporin derivative and its salt Pending JPS565486A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8170379A JPS565486A (en) 1979-06-27 1979-06-27 Cephalosporin derivative and its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8170379A JPS565486A (en) 1979-06-27 1979-06-27 Cephalosporin derivative and its salt

Publications (1)

Publication Number Publication Date
JPS565486A true JPS565486A (en) 1981-01-20

Family

ID=13753734

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8170379A Pending JPS565486A (en) 1979-06-27 1979-06-27 Cephalosporin derivative and its salt

Country Status (1)

Country Link
JP (1) JPS565486A (en)

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