JPS5634633A - Preparation of s-sulfonated immunoglobulin rich in monomer - Google Patents

Preparation of s-sulfonated immunoglobulin rich in monomer

Info

Publication number
JPS5634633A
JPS5634633A JP10964579A JP10964579A JPS5634633A JP S5634633 A JPS5634633 A JP S5634633A JP 10964579 A JP10964579 A JP 10964579A JP 10964579 A JP10964579 A JP 10964579A JP S5634633 A JPS5634633 A JP S5634633A
Authority
JP
Japan
Prior art keywords
value
sulfonated immunoglobulin
monomer
agglutinated material
sulfonated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10964579A
Other languages
Japanese (ja)
Inventor
Shoji Ono
Yuji Fukumoto
Tsunemasa Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken, Teijin Ltd filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
Priority to JP10964579A priority Critical patent/JPS5634633A/en
Priority to CA000359215A priority patent/CA1153695A/en
Priority to US06/182,053 priority patent/US4360457A/en
Priority to AT80303004T priority patent/ATE6740T1/en
Priority to DE8080303004T priority patent/DE3067150D1/en
Priority to EP80303004A priority patent/EP0025321B1/en
Publication of JPS5634633A publication Critical patent/JPS5634633A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PURPOSE: To prepare the titled compound having lowered anticomplementary value and suppressed side effects, by adding a salt of a specific organic compound to a solution of S-slulfonated immunoglobulin containing agglutinated material.
CONSTITUTION: A solution of S-sulfonated immunoglobulin containing agglutinated material, is mixed with 10W600wt%, based on the S-sulfonated immunoglobulin, of a water-soluble salt of a nitrogen-containing organic base having a dissociation index (pKb) of ≥7, e.g. l-arginie hydrochloride, and D-glucosamine hydrochloride, to dissociated the agglutinated material into monomers and to obtain the objective S-sulfonated immunoglobulin rich in monomer. The addition of the water-soluble salt is effective to dissociate the agglutinated material rapidly into the monomers, and to reduce the anticomplimentary value for a long period. The lowering of the anticomplimentary value prevents the anaphylactic side effects accompanied with lowering of blood pressure, algor and pyrexia.
COPYRIGHT: (C)1981,JPO&Japio
JP10964579A 1979-08-30 1979-08-30 Preparation of s-sulfonated immunoglobulin rich in monomer Pending JPS5634633A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP10964579A JPS5634633A (en) 1979-08-30 1979-08-30 Preparation of s-sulfonated immunoglobulin rich in monomer
CA000359215A CA1153695A (en) 1979-08-30 1980-08-28 S-sulfonated immunoglobulin composition having a high monomer content and a process for production thereof
US06/182,053 US4360457A (en) 1979-08-30 1980-08-28 S-Sulfonated immunoglobulin composition having a high monomer content and a process for production thereof
AT80303004T ATE6740T1 (en) 1979-08-30 1980-08-29 COMPOSITION CONTAINING AN S-SULFONATED IMMUNOGLOBULIN AND ANAGAGING PREVENTION OR AGAGING DISSOCIATION AGENT AND METHODS FOR PREPARING COMPOSITIONS CONTAINING A HIGH PROPORTION OF MONOMERIC S-SULFONATED IMMUNOGLOBULINS.
DE8080303004T DE3067150D1 (en) 1979-08-30 1980-08-29 Composition containing s-sulfonated immunoglobulin and aggregation preventing or aggregate dissociating agent therefor, and processes for preparing compositions containing high proportions of monomeric s-sulfonated immunoglobulin
EP80303004A EP0025321B1 (en) 1979-08-30 1980-08-29 Composition containing s-sulfonated immunoglobulin and aggregation preventing or aggregate dissociating agent therefor, and processes for preparing compositions containing high proportions of monomeric s-sulfonated immunoglobulin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10964579A JPS5634633A (en) 1979-08-30 1979-08-30 Preparation of s-sulfonated immunoglobulin rich in monomer

Publications (1)

Publication Number Publication Date
JPS5634633A true JPS5634633A (en) 1981-04-06

Family

ID=14515526

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10964579A Pending JPS5634633A (en) 1979-08-30 1979-08-30 Preparation of s-sulfonated immunoglobulin rich in monomer

Country Status (1)

Country Link
JP (1) JPS5634633A (en)

Similar Documents

Publication Publication Date Title
GR3023958T3 (en) Test device comprising a plate containing a multiplicity of wells with an associated metering device, as well as a kit which comprises these devices and use of the devices.
NO882901L (en) PROCEDURE AND PREPARATION FOR AA PROVIDING AN IMPROVED COMBUSTION IN COMBUSTION PROCESSES CONTAINING HYDROCARBON COMPOUNDS.
DE3069460D1 (en) Production of immunoglobulin having a high monomer content
JPS5363310A (en) Preparation of monomer composition containing pb and preparation of polymerhaving radiation shielding ability
JPS5634633A (en) Preparation of s-sulfonated immunoglobulin rich in monomer
CA2016470A1 (en) Pharmaceutical preparation and method of treatment for liver dysfunction
JPS5634632A (en) S-sulfonated immunoglobulin composition
IE831482L (en) Stabilizing memadione and thiamine
JPS5724634A (en) Deoxydizer composition
DK0393306T3 (en) Water-soluble wood preservative and use of the agent for the pressure and / or vacuum impregnation or immersion process
JPS5625116A (en) Preparation of immunoglobulin having high content of monomer
JPS562189A (en) Treating liquid for use in lithography
JPS53144995A (en) Preparation of silane-crosslinked polyolefin resin composition
JPS54151924A (en) Separaton of toluidine isomers
JPS5212137A (en) Process for preparation of alpha-diketons
JPS5242470A (en) Method of treating waste containing heavy metal salts and making them insoluble
JPS5723096A (en) Preparation of heat collecting plate for solar heat
JPS5259970A (en) Treating device of gas including oxidizable substance
JPS5269884A (en) Oil adsorbent
JPS5267421A (en) Cabureter
JPS55309A (en) N,n'-substituted-paraphenylenediamine derivative, its preparation, and rubber composition containing above derivative as antioxidant
JPS5758870A (en) Preparation of soy sauce having high clutamic acid content
SU1024519A2 (en) Method for processing magnesium production wastes
JPS51136797A (en) Method for preparing a polyamide of high degree of polymerization
MIZUTANI et al. Effects of Amino Acids on the Degradation of Ion Exchangers by Hydrogen Peroxide