JPS5625161A - Pyridine derivative and its preparation - Google Patents

Pyridine derivative and its preparation

Info

Publication number
JPS5625161A
JPS5625161A JP10037779A JP10037779A JPS5625161A JP S5625161 A JPS5625161 A JP S5625161A JP 10037779 A JP10037779 A JP 10037779A JP 10037779 A JP10037779 A JP 10037779A JP S5625161 A JPS5625161 A JP S5625161A
Authority
JP
Japan
Prior art keywords
formula
alkyl
compound
preparation
carbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10037779A
Other languages
Japanese (ja)
Other versions
JPS607982B2 (en
Inventor
Tadao Tauchi
Masanori Kawamura
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Ono Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd, Ono Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Priority to JP10037779A priority Critical patent/JPS607982B2/en
Priority to CA000341817A priority patent/CA1134828A/en
Priority to US06/105,672 priority patent/US4271170A/en
Priority to DE19792951786 priority patent/DE2951786A1/en
Priority to GB7944369A priority patent/GB2039903B/en
Priority to IT51205/79A priority patent/IT1162425B/en
Priority to CH11475/79A priority patent/CH647762A5/en
Priority to FR7931936A priority patent/FR2445319B1/en
Priority to US06/233,703 priority patent/US4317828A/en
Publication of JPS5625161A publication Critical patent/JPS5625161A/en
Priority to US06/329,891 priority patent/US4427682A/en
Priority to FR8214397A priority patent/FR2510108B1/en
Publication of JPS607982B2 publication Critical patent/JPS607982B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Pyridine derivatives of formula I [A is 1W5C alkylene; B, D are single bond, 1W5C alkylene; Z is single bond, ethynylene, formula II (R2 is H, 1W4C alkyl; R3 is H, Br, Cl, 1W4C alkyl; the bond between carbon and carbon is single or double; where the carbon atom linked to R2 connects with B and the one to R3 with D; R is 1W4C alkyl; R1 is H, 1W12C alkyl] or their pharmaceutically permissible salts.
EXAMPLE: (E)-3-[4-(4-Methyl-3-pyridyl)methylphenyl]-2-methylacrylic ethyl ester.
USE: They are used as a remedy for cerebral apoplexy and cardiac infarction because they have actitivity of inhibiting the biosynthesis of thromboxane A2.
PREPARATION: A compound of formula III is subjected to Wittig reaction to produce a compound of formula IV among compounds of formula I and the compound of formula IV is reduced to give a compound of formula V.
COPYRIGHT: (C)1981,JPO&Japio
JP10037779A 1978-12-28 1979-08-07 Pyridine derivative Expired JPS607982B2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP10037779A JPS607982B2 (en) 1979-08-07 1979-08-07 Pyridine derivative
CA000341817A CA1134828A (en) 1978-12-28 1979-12-13 Pyridine derivatives
US06/105,672 US4271170A (en) 1978-12-28 1979-12-20 Pyridine derivatives
DE19792951786 DE2951786A1 (en) 1978-12-28 1979-12-21 PYRIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
GB7944369A GB2039903B (en) 1978-12-28 1979-12-24 Pyridine derivatives
IT51205/79A IT1162425B (en) 1978-12-28 1979-12-27 PYRIDINE DERIVATIVES, PROCEDURE TO PREPARE THEM AND DRUGS CONTAINING THEM
CH11475/79A CH647762A5 (en) 1978-12-28 1979-12-27 PYRIDE DERIVATIVES.
FR7931936A FR2445319B1 (en) 1978-12-28 1979-12-28 PYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US06/233,703 US4317828A (en) 1978-12-28 1981-02-12 Pyridine derivatives
US06/329,891 US4427682A (en) 1978-12-28 1981-12-11 Pyridine alkyl benzoic and thenoic acid compounds and their pharmaceutical compositions
FR8214397A FR2510108B1 (en) 1978-12-28 1982-08-20 PYRIDINE DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10037779A JPS607982B2 (en) 1979-08-07 1979-08-07 Pyridine derivative

Publications (2)

Publication Number Publication Date
JPS5625161A true JPS5625161A (en) 1981-03-10
JPS607982B2 JPS607982B2 (en) 1985-02-28

Family

ID=14272327

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10037779A Expired JPS607982B2 (en) 1978-12-28 1979-08-07 Pyridine derivative

Country Status (1)

Country Link
JP (1) JPS607982B2 (en)

Also Published As

Publication number Publication date
JPS607982B2 (en) 1985-02-28

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