JPS5625115A - Immunoglobulin composition - Google Patents

Immunoglobulin composition

Info

Publication number
JPS5625115A
JPS5625115A JP10075779A JP10075779A JPS5625115A JP S5625115 A JPS5625115 A JP S5625115A JP 10075779 A JP10075779 A JP 10075779A JP 10075779 A JP10075779 A JP 10075779A JP S5625115 A JPS5625115 A JP S5625115A
Authority
JP
Japan
Prior art keywords
concentration
water
soluble salt
immunoglobulin
immunoblobulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10075779A
Other languages
Japanese (ja)
Inventor
Shoji Ono
Yuji Fukumoto
Tsunemasa Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken, Teijin Ltd filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
Priority to JP10075779A priority Critical patent/JPS5625115A/en
Priority to US06/175,739 priority patent/US4362661A/en
Priority to EP80302740A priority patent/EP0025275B1/en
Priority to AT80302740T priority patent/ATE11370T1/en
Priority to DE8080302740T priority patent/DE3070012D1/en
Priority to CA000357959A priority patent/CA1165235A/en
Publication of JPS5625115A publication Critical patent/JPS5625115A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PURPOSE: A composition capable of stabilizing immunoblobulin useful for prevention and remedy for infectious diseases caused by virus and preventing the formation of aggregate for a long time, obtained by adding a water-soluble salt of nitrogen base organic compound having a dissociation constant not more than a specific value to immunoblobulin.
CONSTITUTION: 10W600wt%, preferably 20W400wt% water-soluble salt of nitrogen base organic compound (preferably guanidine hydrochloride) having a dissociation constant PKb {=-log(BH+)/[(B).(H+)] [(B) is concentration of the basic compound; (H+) is concentration of H+; (BH+) is concentration of conjugated acid]} not more than 7 is added to immunoglobulin. For example, the water- soluble salt is directly or in the form of an aqueous solution to a solution of immunoglobulin to give the desired composition.
COPYRIGHT: (C)1981,JPO&Japio
JP10075779A 1979-08-09 1979-08-09 Immunoglobulin composition Pending JPS5625115A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP10075779A JPS5625115A (en) 1979-08-09 1979-08-09 Immunoglobulin composition
US06/175,739 US4362661A (en) 1979-08-09 1980-08-06 Immunoglobulin composition having a high monomer content, and process for production thereof
EP80302740A EP0025275B1 (en) 1979-08-09 1980-08-08 Immunoglobulin-containing composition containing an aggregation preventing or aggregate dissociating agent for the immunoglobulin, and process for preparation thereof
AT80302740T ATE11370T1 (en) 1979-08-09 1980-08-08 COMPOSITION CONTAINING AN IMMUNOGLOBULIN AND ANAGAGING ANTI-AGAGING AGENT OR AGAGING DISSOCIATION AGENT AND PROCESS FOR THE PREPARATION THEREOF.
DE8080302740T DE3070012D1 (en) 1979-08-09 1980-08-08 Immunoglobulin-containing composition containing an aggregation preventing or aggregate dissociating agent for the immunoglobulin, and process for preparation thereof
CA000357959A CA1165235A (en) 1979-08-09 1980-08-11 Immunoglobulin composition having a high monomer content, and process for production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10075779A JPS5625115A (en) 1979-08-09 1979-08-09 Immunoglobulin composition

Publications (1)

Publication Number Publication Date
JPS5625115A true JPS5625115A (en) 1981-03-10

Family

ID=14282378

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10075779A Pending JPS5625115A (en) 1979-08-09 1979-08-09 Immunoglobulin composition

Country Status (1)

Country Link
JP (1) JPS5625115A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56113713A (en) * 1980-02-14 1981-09-07 Chemo Sero Therapeut Res Inst Preparation of immunoglobulin with high content of monomer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACTA CHEMICA SCANDINAVICA=1968 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56113713A (en) * 1980-02-14 1981-09-07 Chemo Sero Therapeut Res Inst Preparation of immunoglobulin with high content of monomer
JPS6160817B2 (en) * 1980-02-14 1986-12-23 Kagaku Oyobi Ketsuseiryoho Kenkyusho

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