JPS56150016A - Antibacterial composition - Google Patents
Antibacterial compositionInfo
- Publication number
- JPS56150016A JPS56150016A JP5223880A JP5223880A JPS56150016A JP S56150016 A JPS56150016 A JP S56150016A JP 5223880 A JP5223880 A JP 5223880A JP 5223880 A JP5223880 A JP 5223880A JP S56150016 A JPS56150016 A JP S56150016A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- acid
- antibacterial
- pipemidic
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 6
- 229960001732 pipemidic acid Drugs 0.000 abstract 3
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229960000210 nalidixic acid Drugs 0.000 abstract 2
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 abstract 2
- NFTOEHBFQROATQ-UHFFFAOYSA-N 2,3-dihydrofuran-5-carboxylic acid Chemical compound OC(=O)C1=CCCO1 NFTOEHBFQROATQ-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 229960000321 oxolinic acid Drugs 0.000 abstract 1
- 229960004444 piromidic acid Drugs 0.000 abstract 1
- RCIMBBZXSXFZBV-UHFFFAOYSA-N piromidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCCC1 RCIMBBZXSXFZBV-UHFFFAOYSA-N 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To prepare an antibacterial composition containing two or more compounds selected from pipemidic acid, naledixic acid, etc. and having synergistic antibacterial effect.
CONSTITUTION: A composition containing at least two drug components selected from pipemidic acid of formula I, nalidixic acid of formula II, piromidic acid of formula III and oxolinic acid of formula IV. The pref. weight ratios of the components II, + and IV to the component I are 0.25W60, 0.25W4 and 0.03W0.13, respectively. These compounds are chemotherapeutics having τ-pyridone-β-carboxylic acid structure and have high safety. Although pipemidic acid of formula I has high antibacterial activity mainly against Gram-negative bacilli and is effective also to Pseudomonas aeruginosa and bacteria resistant to nalidixic acid of formula II, its antibacterial spectrum can be widened and the antibacterial activity can be improved by the combination with the drugs of formula II, formula III and/or formula IV.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5223880A JPS56150016A (en) | 1980-04-22 | 1980-04-22 | Antibacterial composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5223880A JPS56150016A (en) | 1980-04-22 | 1980-04-22 | Antibacterial composition |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56150016A true JPS56150016A (en) | 1981-11-20 |
Family
ID=12909135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5223880A Pending JPS56150016A (en) | 1980-04-22 | 1980-04-22 | Antibacterial composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56150016A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2521858A1 (en) * | 1982-02-22 | 1983-08-26 | Foscama Biomed Chim Farma | NOVEL TRIMETHOPRIM-PIPEMIDIC ACID ANTIBACTERIAL ASSOCIATION |
-
1980
- 1980-04-22 JP JP5223880A patent/JPS56150016A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2521858A1 (en) * | 1982-02-22 | 1983-08-26 | Foscama Biomed Chim Farma | NOVEL TRIMETHOPRIM-PIPEMIDIC ACID ANTIBACTERIAL ASSOCIATION |
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