JPS56135479A - Novel piperazinopyrimidine derivative - Google Patents
Novel piperazinopyrimidine derivativeInfo
- Publication number
- JPS56135479A JPS56135479A JP3843680A JP3843680A JPS56135479A JP S56135479 A JPS56135479 A JP S56135479A JP 3843680 A JP3843680 A JP 3843680A JP 3843680 A JP3843680 A JP 3843680A JP S56135479 A JPS56135479 A JP S56135479A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkylthio
- compound
- amino
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:Compounds of formula I (R1 and R2 together form a condensed benzene ring which may be substituted with 3W5C methylene chain or alkoxy group; R3 is mono- or dialkylamino, pyrrolidino, piperidino, morpholino which may be substituted with amino or hydroxyl groups; R is alkoxy, alkylthio, alkylamino) and their pharmaceutically permissible acid adducts.
EXAMPLE: 4-Amino-2-[ 4-( methylthio-N-cyanoiminocarbonyl )piperazino ]-5, 6-tetramethylenepyrimidine.
USE: A histamine H2 receptor blocking agent: they have activities of inhibiting the secretion of stomach acid, of anti-inflammation and effect on cardiovascular system.
PREPARATION: The reaction of a compound of formula II with another compound of formula III (R4 is alkylthio) affords a compound of formula I where R is alkylthio.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3843680A JPS56135479A (en) | 1980-03-26 | 1980-03-26 | Novel piperazinopyrimidine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3843680A JPS56135479A (en) | 1980-03-26 | 1980-03-26 | Novel piperazinopyrimidine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56135479A true JPS56135479A (en) | 1981-10-22 |
Family
ID=12525250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3843680A Pending JPS56135479A (en) | 1980-03-26 | 1980-03-26 | Novel piperazinopyrimidine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56135479A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6165873A (en) * | 1984-09-07 | 1986-04-04 | Mitsui Petrochem Ind Ltd | 2-piperazinopyrimidine derivative |
| WO2022034121A1 (en) | 2020-08-11 | 2022-02-17 | Université De Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
-
1980
- 1980-03-26 JP JP3843680A patent/JPS56135479A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6165873A (en) * | 1984-09-07 | 1986-04-04 | Mitsui Petrochem Ind Ltd | 2-piperazinopyrimidine derivative |
| JPH0522703B2 (en) * | 1984-09-07 | 1993-03-30 | Mitsui Petrochemical Ind | |
| WO2022034121A1 (en) | 2020-08-11 | 2022-02-17 | Université De Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
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