JPS5612400A - N2-substituted phenyl-2,6-diaminonebularine - Google Patents

N2-substituted phenyl-2,6-diaminonebularine

Info

Publication number
JPS5612400A
JPS5612400A JP8707479A JP8707479A JPS5612400A JP S5612400 A JPS5612400 A JP S5612400A JP 8707479 A JP8707479 A JP 8707479A JP 8707479 A JP8707479 A JP 8707479A JP S5612400 A JPS5612400 A JP S5612400A
Authority
JP
Japan
Prior art keywords
formula
compound
diaminonebularine
ammonia
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8707479A
Other languages
Japanese (ja)
Other versions
JPS633876B2 (en
Inventor
Ryuji Marumoto
Masao Tanabe
Sumiyasu Furukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP8707479A priority Critical patent/JPS5612400A/en
Priority to AU51189/79A priority patent/AU5118979A/en
Priority to CH908379A priority patent/CH642668A5/en
Priority to DK430379A priority patent/DK430379A/en
Priority to US06/085,057 priority patent/US4258033A/en
Priority to SE7908480A priority patent/SE7908480L/en
Priority to DE19792941592 priority patent/DE2941592A1/en
Priority to CA337,577A priority patent/CA1112641A/en
Priority to NL7907611A priority patent/NL7907611A/en
Priority to IT26502/79A priority patent/IT1125480B/en
Priority to FR7925642A priority patent/FR2439207A1/en
Priority to GB7935932A priority patent/GB2034704B/en
Publication of JPS5612400A publication Critical patent/JPS5612400A/en
Publication of JPS633876B2 publication Critical patent/JPS633876B2/ja
Granted legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The titled compound (salt) expressed by formula I [either of R1 and R2 is -COR3 (R3 is lower alkyl group), and the other is H, halogen or lower alkoxy group].
EXAMPLE: N2-(3-Propionylphenyl)-2,6-diaminonebularine.
USE: A remedy for ischemic diseases such as coronary insufficiency, angina pectoris, or cardiac infarction having a coronary artery vasodilator action.
PROCESS: A compound of formula II (R4, R5 and R6 are hydroxyl groups which may be protected; A is active group which reacts with ammonia to form an amino group) is reacted with ammonia in a molar amount of preferably 2W5 times that of the compound of formula II, preferably in the presence of a lower alcohol solvent, at 100W200°C in a closed vessel under heating to afford the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP8707479A 1978-10-16 1979-07-09 N2-substituted phenyl-2,6-diaminonebularine Granted JPS5612400A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP8707479A JPS5612400A (en) 1979-07-09 1979-07-09 N2-substituted phenyl-2,6-diaminonebularine
AU51189/79A AU5118979A (en) 1978-10-16 1979-09-26 2,6-diaminoebularines
CH908379A CH642668A5 (en) 1978-10-16 1979-10-09 2,6-DIAMINONEBULARINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME.
DK430379A DK430379A (en) 1978-10-16 1979-10-11 PROCEDURE FOR THE PREPARATION OF 2,6-DIAMINONEBULARIN OR ACID ADDITION SALTS THEREOF
US06/085,057 US4258033A (en) 1978-10-16 1979-10-12 2,6-Diaminonebularines
SE7908480A SE7908480L (en) 1978-10-16 1979-10-12 NEW 2,6-DIAMINONE BULAR INDIVIDUALS
DE19792941592 DE2941592A1 (en) 1978-10-16 1979-10-13 2,6-DIAMINONEBULARINE AND METHOD FOR THE PRODUCTION THEREOF
CA337,577A CA1112641A (en) 1978-10-16 1979-10-15 2,6-diaminonebularines
NL7907611A NL7907611A (en) 1978-10-16 1979-10-15 NEW 2,6-DIAMINONEBULARINES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS.
IT26502/79A IT1125480B (en) 1978-10-16 1979-10-15 COMPOUND BASED ON 2,6-DIAMINE-NEBULARINE
FR7925642A FR2439207A1 (en) 1978-10-16 1979-10-16 2,6-DIAMINONEBULARINES, THEIR PREPARATION PROCESS AND THEIR APPLICATION TO PHARMACEUTICAL COMPOSITIONS
GB7935932A GB2034704B (en) 1978-10-16 1979-10-16 2,6-daiminonebularines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8707479A JPS5612400A (en) 1979-07-09 1979-07-09 N2-substituted phenyl-2,6-diaminonebularine

Publications (2)

Publication Number Publication Date
JPS5612400A true JPS5612400A (en) 1981-02-06
JPS633876B2 JPS633876B2 (en) 1988-01-26

Family

ID=13904788

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8707479A Granted JPS5612400A (en) 1978-10-16 1979-07-09 N2-substituted phenyl-2,6-diaminonebularine

Country Status (1)

Country Link
JP (1) JPS5612400A (en)

Also Published As

Publication number Publication date
JPS633876B2 (en) 1988-01-26

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