JPS56123928A - Preparation of diol derivative - Google Patents
Preparation of diol derivativeInfo
- Publication number
- JPS56123928A JPS56123928A JP2660480A JP2660480A JPS56123928A JP S56123928 A JPS56123928 A JP S56123928A JP 2660480 A JP2660480 A JP 2660480A JP 2660480 A JP2660480 A JP 2660480A JP S56123928 A JPS56123928 A JP S56123928A
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- formula
- derivative
- diol derivative
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare an optically active diol derivative which can be converted to an optically active β-blocker, economically, in an industrial scale, by reacting an optically active halohydrin derivative with an aromatic alcohol under basic conditions.
CONSTITUTION: An optically active diol derivative of formula III (Ar is aromatic group) can be prepared in a short step, without racemization, by reacting a halohydrin derivative of formula I (X is halogen; one of Y and Z is H and the other is acryl) with an alcohol of formula II in the presence of a base (e.g. alkali metal alkoxide. oxide or carbonate, alkaline earth metal hydroxide, etc.), pref. in an aqueous solvent. The optically active compound of formula I can be obtained easily by the asymmetric hydrolysis of 1,2-diacyloxy-3-halopropane with lipase, and the compound of formula II is also available easily as an industrial raw material.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2660480A JPS56123928A (en) | 1980-03-05 | 1980-03-05 | Preparation of diol derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2660480A JPS56123928A (en) | 1980-03-05 | 1980-03-05 | Preparation of diol derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56123928A true JPS56123928A (en) | 1981-09-29 |
JPS6338972B2 JPS6338972B2 (en) | 1988-08-03 |
Family
ID=12198107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2660480A Granted JPS56123928A (en) | 1980-03-05 | 1980-03-05 | Preparation of diol derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56123928A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51125056A (en) * | 1974-10-09 | 1976-11-01 | Otsuka Pharmaceut Co Ltd | A process for preparing glycerol derivatives |
-
1980
- 1980-03-05 JP JP2660480A patent/JPS56123928A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51125056A (en) * | 1974-10-09 | 1976-11-01 | Otsuka Pharmaceut Co Ltd | A process for preparing glycerol derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS6338972B2 (en) | 1988-08-03 |
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