JPS56113710A - Preparation of prolonged action composition substance - Google Patents
Preparation of prolonged action composition substanceInfo
- Publication number
- JPS56113710A JPS56113710A JP1640580A JP1640580A JPS56113710A JP S56113710 A JPS56113710 A JP S56113710A JP 1640580 A JP1640580 A JP 1640580A JP 1640580 A JP1640580 A JP 1640580A JP S56113710 A JPS56113710 A JP S56113710A
- Authority
- JP
- Japan
- Prior art keywords
- human serum
- physiologically active
- serum protein
- substance
- prolonged action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To obtain a prolonged action composite substance administrable in the interior of the tissue and a long prolonged time of release, by bringing a physiologically active substance into contact with human serum protein, denaturing the protein, followed by fixing and including the physiologically active substance in it.
CONSTITUTION: One or two or more kinds of physiologically active substances (e.g., cyclophosphamide, adriamycin) is brought into contact with an aqeuous solution consisting of one or two or more kinds of human serum protein (e.g., human serum albumin, human serum globurin). The human serum protein is heat-treated so that it is denatured, and the physiologically active substances are dispersed into the matrix of the denatured human serum protein, fixed, and included, to give a prolonged action composite substance. This process may be repeated to form a multilayer construction. Since the composite substance is derived from human serum protein, it has no antigenicity and is administrable into the interior of the tissue.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1640580A JPS5911564B2 (en) | 1980-02-13 | 1980-02-13 | Method for producing sustained release complex |
DE3104815A DE3104815C2 (en) | 1980-02-13 | 1981-02-11 | Method of making a composite with long-term release |
US06/514,026 US4582719A (en) | 1980-02-13 | 1983-07-15 | Process for producing a slow release composite |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1640580A JPS5911564B2 (en) | 1980-02-13 | 1980-02-13 | Method for producing sustained release complex |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56113710A true JPS56113710A (en) | 1981-09-07 |
JPS5911564B2 JPS5911564B2 (en) | 1984-03-16 |
Family
ID=11915326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1640580A Expired JPS5911564B2 (en) | 1980-02-13 | 1980-02-13 | Method for producing sustained release complex |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5911564B2 (en) |
-
1980
- 1980-02-13 JP JP1640580A patent/JPS5911564B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5911564B2 (en) | 1984-03-16 |
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