JPS56113710A - Preparation of prolonged action composition substance - Google Patents

Preparation of prolonged action composition substance

Info

Publication number
JPS56113710A
JPS56113710A JP1640580A JP1640580A JPS56113710A JP S56113710 A JPS56113710 A JP S56113710A JP 1640580 A JP1640580 A JP 1640580A JP 1640580 A JP1640580 A JP 1640580A JP S56113710 A JPS56113710 A JP S56113710A
Authority
JP
Japan
Prior art keywords
human serum
physiologically active
serum protein
substance
prolonged action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1640580A
Other languages
Japanese (ja)
Other versions
JPS5911564B2 (en
Inventor
Isao Kaetsu
Masaharu Asano
Minoru Kumakura
Masaru Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Atomic Energy Agency
Original Assignee
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Atomic Energy Research Institute filed Critical Japan Atomic Energy Research Institute
Priority to JP1640580A priority Critical patent/JPS5911564B2/en
Priority to DE3104815A priority patent/DE3104815C2/en
Publication of JPS56113710A publication Critical patent/JPS56113710A/en
Priority to US06/514,026 priority patent/US4582719A/en
Publication of JPS5911564B2 publication Critical patent/JPS5911564B2/en
Expired legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To obtain a prolonged action composite substance administrable in the interior of the tissue and a long prolonged time of release, by bringing a physiologically active substance into contact with human serum protein, denaturing the protein, followed by fixing and including the physiologically active substance in it.
CONSTITUTION: One or two or more kinds of physiologically active substances (e.g., cyclophosphamide, adriamycin) is brought into contact with an aqeuous solution consisting of one or two or more kinds of human serum protein (e.g., human serum albumin, human serum globurin). The human serum protein is heat-treated so that it is denatured, and the physiologically active substances are dispersed into the matrix of the denatured human serum protein, fixed, and included, to give a prolonged action composite substance. This process may be repeated to form a multilayer construction. Since the composite substance is derived from human serum protein, it has no antigenicity and is administrable into the interior of the tissue.
COPYRIGHT: (C)1981,JPO&Japio
JP1640580A 1980-02-13 1980-02-13 Method for producing sustained release complex Expired JPS5911564B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP1640580A JPS5911564B2 (en) 1980-02-13 1980-02-13 Method for producing sustained release complex
DE3104815A DE3104815C2 (en) 1980-02-13 1981-02-11 Method of making a composite with long-term release
US06/514,026 US4582719A (en) 1980-02-13 1983-07-15 Process for producing a slow release composite

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1640580A JPS5911564B2 (en) 1980-02-13 1980-02-13 Method for producing sustained release complex

Publications (2)

Publication Number Publication Date
JPS56113710A true JPS56113710A (en) 1981-09-07
JPS5911564B2 JPS5911564B2 (en) 1984-03-16

Family

ID=11915326

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1640580A Expired JPS5911564B2 (en) 1980-02-13 1980-02-13 Method for producing sustained release complex

Country Status (1)

Country Link
JP (1) JPS5911564B2 (en)

Also Published As

Publication number Publication date
JPS5911564B2 (en) 1984-03-16

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