JPS5598162A - Novel 1-substituted-3-acylpyrrole derivative, its preparation and blood platelet coagulation preventive containing the same - Google Patents
Novel 1-substituted-3-acylpyrrole derivative, its preparation and blood platelet coagulation preventive containing the sameInfo
- Publication number
- JPS5598162A JPS5598162A JP472779A JP472779A JPS5598162A JP S5598162 A JPS5598162 A JP S5598162A JP 472779 A JP472779 A JP 472779A JP 472779 A JP472779 A JP 472779A JP S5598162 A JPS5598162 A JP S5598162A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- formula
- phenyl
- acylpyrrole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:1-Substituted-3-acylpyrrole derivatives of formula I [ϕ is phenyl or substituted phenyl, cycloalkyl, branched alkyl, 5 or 6-membered heterocycle; R1 is H, 1W4C alkyl; Y is phenyl, benzyl, 1W4C alkyl, 1W4C hydrocarbyl chain; R2WR4 are selected from cases of (1) or (2), wherein (1) R2 is formula XR5 (X is O, S, sulfinyl; R5 is H, 1W10C alkyl, phenyl); R3 and R4 are H, 1W4C alkyl, carboxyl group; (2) R2 and R3 incorporate to form oxo and R4 is H, 1W4C alkyl and phenoxy].
EXAMPLE: 3-(3-Benzoyl-2,5-dimethylpyrrol-1-yl)propanol.
USE: Blood platelet coagulation preventive with low anti-inflammatory activity.
PREPARATION: The condensation reaction between a 1-substituted pyrrole derivative of formula II and an anhydride or halide of carboxylic acid of ϕ-COOH is conducted in the presence of an acidic catalyst to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP472779A JPS5598162A (en) | 1979-01-22 | 1979-01-22 | Novel 1-substituted-3-acylpyrrole derivative, its preparation and blood platelet coagulation preventive containing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP472779A JPS5598162A (en) | 1979-01-22 | 1979-01-22 | Novel 1-substituted-3-acylpyrrole derivative, its preparation and blood platelet coagulation preventive containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5598162A true JPS5598162A (en) | 1980-07-25 |
Family
ID=11591920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP472779A Pending JPS5598162A (en) | 1979-01-22 | 1979-01-22 | Novel 1-substituted-3-acylpyrrole derivative, its preparation and blood platelet coagulation preventive containing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5598162A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870192A (en) * | 2021-01-15 | 2021-06-01 | 广西壮族自治区农业科学院 | Application of alkaloid compound in preparation of medicine for inhibiting platelet aggregation |
-
1979
- 1979-01-22 JP JP472779A patent/JPS5598162A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870192A (en) * | 2021-01-15 | 2021-06-01 | 广西壮族自治区农业科学院 | Application of alkaloid compound in preparation of medicine for inhibiting platelet aggregation |
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