JPS5598115A - Bacteriolytic agent for gram-negative bacteria - Google Patents

Bacteriolytic agent for gram-negative bacteria

Info

Publication number
JPS5598115A
JPS5598115A JP373179A JP373179A JPS5598115A JP S5598115 A JPS5598115 A JP S5598115A JP 373179 A JP373179 A JP 373179A JP 373179 A JP373179 A JP 373179A JP S5598115 A JPS5598115 A JP S5598115A
Authority
JP
Japan
Prior art keywords
gram
negative bacteria
medium
bacteriolytic
negalycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP373179A
Other languages
Japanese (ja)
Other versions
JPS6047245B2 (en
Inventor
Yoshiyuki Takahara
Sawao Murao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP54003731A priority Critical patent/JPS6047245B2/en
Publication of JPS5598115A publication Critical patent/JPS5598115A/en
Publication of JPS6047245B2 publication Critical patent/JPS6047245B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PURPOSE: To provide the title agent highly effective even under mild physiological conditions, containing an enzyme, negalycin, and a novel cyclic acylpeptide antibiotic substance, permetin.
CONSTITUTION: A bacteriolytic agent effective to gram-negative bacteria containing (A) negalycin [e.g. prepared by culturing Bacillus subtilis AJ 3449 (FERM-P No. 1962) in a nutrient medium, separating from the medium with a weakly acidic cation exchange resin, etc., and purifying the product], and (B) permetin A [e.g. prepared by culturing Bacillus circulans AJ 3902 (FERM-P No.3097) aerobically in a nutrient medium, extracting from the medium with an organic solvent, and purifying the product]. The weight ratio of (A) to (B) is pref. 1 to 1W20, and the concentrations of (A) and (B) necessary to effect the bacteriolysis of living gram-negative bacteria are 2W20μg/ml and 10W100μg/ml, respectively. Each component has no bacteriolytic activity when used separately.
COPYRIGHT: (C)1980,JPO&Japio
JP54003731A 1979-01-16 1979-01-16 Gram-negative bacteriolytic agent Expired JPS6047245B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP54003731A JPS6047245B2 (en) 1979-01-16 1979-01-16 Gram-negative bacteriolytic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54003731A JPS6047245B2 (en) 1979-01-16 1979-01-16 Gram-negative bacteriolytic agent

Publications (2)

Publication Number Publication Date
JPS5598115A true JPS5598115A (en) 1980-07-25
JPS6047245B2 JPS6047245B2 (en) 1985-10-21

Family

ID=11565397

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54003731A Expired JPS6047245B2 (en) 1979-01-16 1979-01-16 Gram-negative bacteriolytic agent

Country Status (1)

Country Link
JP (1) JPS6047245B2 (en)

Also Published As

Publication number Publication date
JPS6047245B2 (en) 1985-10-21

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