JPS5576898A - Preparation of 3'-deoxycytidine - Google Patents

Preparation of 3'-deoxycytidine

Info

Publication number
JPS5576898A
JPS5576898A JP14956678A JP14956678A JPS5576898A JP S5576898 A JPS5576898 A JP S5576898A JP 14956678 A JP14956678 A JP 14956678A JP 14956678 A JP14956678 A JP 14956678A JP S5576898 A JPS5576898 A JP S5576898A
Authority
JP
Japan
Prior art keywords
derivative
formula
condensation reaction
lewis acid
deoxyribose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14956678A
Other languages
Japanese (ja)
Inventor
Minero Saneyoshi
Junichi Toyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP14956678A priority Critical patent/JPS5576898A/en
Publication of JPS5576898A publication Critical patent/JPS5576898A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: The condensation reaction between a cytosine derivative and 3-deoxyribose derivative is effected in the presence a Lewis acid and protecting groups are removed to prepare title compound that is important as synthetic intermediate of pyrimidine-3'-deoxynucleoside derivatives with reduced steps in high yield.
CONSTITUTION: N4-Acylcytosine of formula I (R1 is acyl) is silylated with hexamethyldisilazane or trimethylchlorosilane and subjected to condensation reaction with a 3-deoxyribose derivative of formula II (R2 is aroyl; R3 is alkylcarbonyloxy, or halogen) in the presence of a Lewis acid as tin tetrachloride and the prorecting groups are removed by treating with an alkoxide to give 3'-deoxycitydine of formula III. The 3-deoxyribose derivative is obtained from cordycepin that is readily prepared by fermentation by only two steps.
COPYRIGHT: (C)1980,JPO&Japio
JP14956678A 1978-12-01 1978-12-01 Preparation of 3'-deoxycytidine Pending JPS5576898A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14956678A JPS5576898A (en) 1978-12-01 1978-12-01 Preparation of 3'-deoxycytidine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14956678A JPS5576898A (en) 1978-12-01 1978-12-01 Preparation of 3'-deoxycytidine

Publications (1)

Publication Number Publication Date
JPS5576898A true JPS5576898A (en) 1980-06-10

Family

ID=15477974

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14956678A Pending JPS5576898A (en) 1978-12-01 1978-12-01 Preparation of 3'-deoxycytidine

Country Status (1)

Country Link
JP (1) JPS5576898A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103772460A (en) * 2014-02-14 2014-05-07 江苏省中国科学院植物研究所 Extraction process of cordycepin (active substance) from silkworm pupa cordyceps militaris

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103772460A (en) * 2014-02-14 2014-05-07 江苏省中国科学院植物研究所 Extraction process of cordycepin (active substance) from silkworm pupa cordyceps militaris

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