JPS557228A - Enzyme preparation - Google Patents

Enzyme preparation

Info

Publication number
JPS557228A
JPS557228A JP7908178A JP7908178A JPS557228A JP S557228 A JPS557228 A JP S557228A JP 7908178 A JP7908178 A JP 7908178A JP 7908178 A JP7908178 A JP 7908178A JP S557228 A JPS557228 A JP S557228A
Authority
JP
Japan
Prior art keywords
water
oil
enzyme
phase contains
water phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7908178A
Other languages
Japanese (ja)
Other versions
JPS633848B2 (en
Inventor
Norio Yanagibashi
Hidenori Fukuda
Minako Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Lion Hamigaki KK
Original Assignee
Lion Corp
Lion Hamigaki KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp, Lion Hamigaki KK filed Critical Lion Corp
Priority to JP7908178A priority Critical patent/JPS557228A/en
Publication of JPS557228A publication Critical patent/JPS557228A/en
Publication of JPS633848B2 publication Critical patent/JPS633848B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: To obtain an enzyme preparation having improved stability and capable of being administered even by injection, composed of a water/oil/water composite emulsion wherein the innermost water phase contains the enzyme.
CONSTITUTION: A water/oil/water-type composite emulsion wherein the inner water phase contains an enzyme (e.g. L-asparaginase, arginase, urokinase, lysozyme, etc.) The outer water phase contains a weak alkali salt and a water-soluble emulsifier, and the oil phase contains the oil component, a fatty acid and an oil- soluble emulsifier. The inner water phase pref. contains a monosaccharide, sugar alcohol, etc. The preparation has similar activity to the micro-encapsulated enzyme and high stability, inhibits the antigen-antibody reaction, and can be administered in high dose.
COPYRIGHT: (C)1980,JPO&Japio
JP7908178A 1978-06-29 1978-06-29 Enzyme preparation Granted JPS557228A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7908178A JPS557228A (en) 1978-06-29 1978-06-29 Enzyme preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7908178A JPS557228A (en) 1978-06-29 1978-06-29 Enzyme preparation

Publications (2)

Publication Number Publication Date
JPS557228A true JPS557228A (en) 1980-01-19
JPS633848B2 JPS633848B2 (en) 1988-01-26

Family

ID=13679936

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7908178A Granted JPS557228A (en) 1978-06-29 1978-06-29 Enzyme preparation

Country Status (1)

Country Link
JP (1) JPS557228A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5643209A (en) * 1979-09-14 1981-04-21 Kowa Co External drug of urokinase
JPH09511744A (en) * 1994-04-07 1997-11-25 ファーマヴィーン，インコーポレイテッド Multi-layer drug delivery system
WO2005023282A1 (en) * 2003-09-03 2005-03-17 Ltt Bio-Pharma Co., Ltd. Nanoparticle containing physiologically active protein or peptide, process for producing the same and external preparation comprising the nanoparticle
JP2014509602A (en) * 2011-03-14 2014-04-21 ドラッグ デリバリー ソリューションズ リミテッド Ophthalmic composition
JP2014221043A (en) * 2014-06-04 2014-11-27 学校法人神奈川大学 W/o/w type emulsion, enzyme preservation liquid of w/o/w type emulsion, and enzyme preservation method

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5643209A (en) * 1979-09-14 1981-04-21 Kowa Co External drug of urokinase
JPH09511744A (en) * 1994-04-07 1997-11-25 ファーマヴィーン，インコーポレイテッド Multi-layer drug delivery system
WO2005023282A1 (en) * 2003-09-03 2005-03-17 Ltt Bio-Pharma Co., Ltd. Nanoparticle containing physiologically active protein or peptide, process for producing the same and external preparation comprising the nanoparticle
JP2014509602A (en) * 2011-03-14 2014-04-21 ドラッグ デリバリー ソリューションズ リミテッド Ophthalmic composition
JP2014221043A (en) * 2014-06-04 2014-11-27 学校法人神奈川大学 W/o/w type emulsion, enzyme preservation liquid of w/o/w type emulsion, and enzyme preservation method

Also Published As

Publication number Publication date
JPS633848B2 (en) 1988-01-26

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