JPS5470231A - Preparation of optically active benzyl alcohol derivative - Google Patents
Preparation of optically active benzyl alcohol derivativeInfo
- Publication number
- JPS5470231A JPS5470231A JP13703677A JP13703677A JPS5470231A JP S5470231 A JPS5470231 A JP S5470231A JP 13703677 A JP13703677 A JP 13703677A JP 13703677 A JP13703677 A JP 13703677A JP S5470231 A JPS5470231 A JP S5470231A
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- acid
- preparation
- benzyl alcohol
- alcohol derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound, by the condensation of optically active 4- hydroxymandelic acid with benzyl halides, then with 3,4-dimethoxyphenethylamine, reduction of the carbonyl group to a methylene group, followed by catalylic reduction of the alcohol thus formed.
CONSTITUTION: L-4-Hydroxymandelic acid is condensed with benzyl halides to form L-4-benzyloxymandelic acid, which is then condensed with 3,4-dimethoxyphenethylamine to give L-N-(3,4-dimethoxyphenethyl)-4-benxylozymandelic acid amide. The carbonyl group of the amide is reduced to a methylene group, then catalytically reduced to form L-α-(3,4-dimethoxyphenethylaminomethyl)-4- hydroxybenzyl alcohol.
EFFECT: Smooth reaction provides the desired products in high yields.
USE: Pharmaceuticals having powerful and durable cardiotonic actions.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13703677A JPS609701B2 (en) | 1977-11-14 | 1977-11-14 | Method for producing optically active benzyl alcohol derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13703677A JPS609701B2 (en) | 1977-11-14 | 1977-11-14 | Method for producing optically active benzyl alcohol derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5470231A true JPS5470231A (en) | 1979-06-05 |
| JPS609701B2 JPS609701B2 (en) | 1985-03-12 |
Family
ID=15189341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13703677A Expired JPS609701B2 (en) | 1977-11-14 | 1977-11-14 | Method for producing optically active benzyl alcohol derivatives |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS609701B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007505897A (en) * | 2003-09-19 | 2007-03-15 | ギョンイン シンセティック コーポレイション | (Α-Hydroxy) phenylacetic acid derivative, compound based on it and having two 5-membered lactone rings condensed with central cyclohexa-1,4-diene nucleus and use thereof |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61150201U (en) * | 1985-03-11 | 1986-09-17 | ||
| JPH0349105Y2 (en) * | 1986-11-14 | 1991-10-21 |
-
1977
- 1977-11-14 JP JP13703677A patent/JPS609701B2/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007505897A (en) * | 2003-09-19 | 2007-03-15 | ギョンイン シンセティック コーポレイション | (Α-Hydroxy) phenylacetic acid derivative, compound based on it and having two 5-membered lactone rings condensed with central cyclohexa-1,4-diene nucleus and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS609701B2 (en) | 1985-03-12 |
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