JPS5572152A - Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt - Google Patents
Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its saltInfo
- Publication number
- JPS5572152A JPS5572152A JP14495578A JP14495578A JPS5572152A JP S5572152 A JPS5572152 A JP S5572152A JP 14495578 A JP14495578 A JP 14495578A JP 14495578 A JP14495578 A JP 14495578A JP S5572152 A JPS5572152 A JP S5572152A
- Authority
- JP
- Japan
- Prior art keywords
- copper
- copper powder
- alkali metal
- acid
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound useful as an antiphlogistic and analgesic agent, in high yield, by reacting an alkali metal salt of an ortho-halogenophenylacetic acid with 2,6-dichloroformanilide in the presence of copper powder.
CONSTITUTION: The compound I is prepared by (1) reacting an alkali metal salt of an ortho-halogenophenylacetic acid II (X is halogen; M is alkali metal) with a 2,6-dichloro-aniline derivative III (Y is formyl, sulfone, or OH) in the absence or presence of solvent such as DMF, in the presence of copper (copper powder, reduced copper powder obtained by treating copper sulfate with Zn, or copper powder or copper oxide treated with iodine in acetone), and (2) hydrolyzing the resulting compound IV with an acid.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14495578A JPS5572152A (en) | 1978-11-25 | 1978-11-25 | Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14495578A JPS5572152A (en) | 1978-11-25 | 1978-11-25 | Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5572152A true JPS5572152A (en) | 1980-05-30 |
Family
ID=15374071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14495578A Pending JPS5572152A (en) | 1978-11-25 | 1978-11-25 | Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5572152A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4410724A (en) * | 1980-10-20 | 1983-10-18 | Zenyaku Kogyo Kabushiki Kaisha | Process for production of o-(2,6-dichloroanilino)-phenylacetic acid |
-
1978
- 1978-11-25 JP JP14495578A patent/JPS5572152A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4410724A (en) * | 1980-10-20 | 1983-10-18 | Zenyaku Kogyo Kabushiki Kaisha | Process for production of o-(2,6-dichloroanilino)-phenylacetic acid |
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