JPS5572152A - Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt - Google Patents

Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt

Info

Publication number
JPS5572152A
JPS5572152A JP14495578A JP14495578A JPS5572152A JP S5572152 A JPS5572152 A JP S5572152A JP 14495578 A JP14495578 A JP 14495578A JP 14495578 A JP14495578 A JP 14495578A JP S5572152 A JPS5572152 A JP S5572152A
Authority
JP
Japan
Prior art keywords
copper
copper powder
alkali metal
acid
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14495578A
Other languages
Japanese (ja)
Inventor
Kazuo Ohira
Hiroshi Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SANPO KAGAKU KOGYO KK
Taiyo Pharmaceutical Industry Co Ltd
Original Assignee
SANPO KAGAKU KOGYO KK
Taiyo Pharmaceutical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SANPO KAGAKU KOGYO KK, Taiyo Pharmaceutical Industry Co Ltd filed Critical SANPO KAGAKU KOGYO KK
Priority to JP14495578A priority Critical patent/JPS5572152A/en
Publication of JPS5572152A publication Critical patent/JPS5572152A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound useful as an antiphlogistic and analgesic agent, in high yield, by reacting an alkali metal salt of an ortho-halogenophenylacetic acid with 2,6-dichloroformanilide in the presence of copper powder.
CONSTITUTION: The compound I is prepared by (1) reacting an alkali metal salt of an ortho-halogenophenylacetic acid II (X is halogen; M is alkali metal) with a 2,6-dichloro-aniline derivative III (Y is formyl, sulfone, or OH) in the absence or presence of solvent such as DMF, in the presence of copper (copper powder, reduced copper powder obtained by treating copper sulfate with Zn, or copper powder or copper oxide treated with iodine in acetone), and (2) hydrolyzing the resulting compound IV with an acid.
COPYRIGHT: (C)1980,JPO&Japio
JP14495578A 1978-11-25 1978-11-25 Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt Pending JPS5572152A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14495578A JPS5572152A (en) 1978-11-25 1978-11-25 Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14495578A JPS5572152A (en) 1978-11-25 1978-11-25 Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt

Publications (1)

Publication Number Publication Date
JPS5572152A true JPS5572152A (en) 1980-05-30

Family

ID=15374071

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14495578A Pending JPS5572152A (en) 1978-11-25 1978-11-25 Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt

Country Status (1)

Country Link
JP (1) JPS5572152A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410724A (en) * 1980-10-20 1983-10-18 Zenyaku Kogyo Kabushiki Kaisha Process for production of o-(2,6-dichloroanilino)-phenylacetic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410724A (en) * 1980-10-20 1983-10-18 Zenyaku Kogyo Kabushiki Kaisha Process for production of o-(2,6-dichloroanilino)-phenylacetic acid

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