JPS5562070A - Production of 1-(o-chlorophenylbisphenylmethyl)imidazole - Google Patents
Production of 1-(o-chlorophenylbisphenylmethyl)imidazoleInfo
- Publication number
- JPS5562070A JPS5562070A JP13538578A JP13538578A JPS5562070A JP S5562070 A JPS5562070 A JP S5562070A JP 13538578 A JP13538578 A JP 13538578A JP 13538578 A JP13538578 A JP 13538578A JP S5562070 A JPS5562070 A JP S5562070A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- imidazolyl
- phosphine
- tri
- imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: o-Chlorophenyldiphenylmethanol that is inexpensive as an intermediate is made to react with an active tri-(1-imidazolyl)phosphine to produce readily title compound showing antifungal activity in high yield.
CONSTITUTION: The Friedel-Craft reaction of o-chlorobenzotrichloride and benzene is effected in the presence of aluminum trichloride and the reaction mixture is treated with water to form a stable intermediate, o-chlorophenyldiphenylmethanol. Then, the reaction of the product with an active tri-(1-imidazolyl)phosphine gives the objective compound. The tri-(1-imidazolyl)phosphine is obtained by reaction of a trialkylsilyl derivative of imidazole with phosphorus trichloride.
EFFECT: The reaction time is remarkably shortened.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13538578A JPS5562070A (en) | 1978-11-01 | 1978-11-01 | Production of 1-(o-chlorophenylbisphenylmethyl)imidazole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13538578A JPS5562070A (en) | 1978-11-01 | 1978-11-01 | Production of 1-(o-chlorophenylbisphenylmethyl)imidazole |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5562070A true JPS5562070A (en) | 1980-05-10 |
Family
ID=15150462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13538578A Pending JPS5562070A (en) | 1978-11-01 | 1978-11-01 | Production of 1-(o-chlorophenylbisphenylmethyl)imidazole |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5562070A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5938949A (en) * | 1982-08-27 | 1984-03-03 | Hitachi Ltd | Magneto-optical reproducer |
-
1978
- 1978-11-01 JP JP13538578A patent/JPS5562070A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5938949A (en) * | 1982-08-27 | 1984-03-03 | Hitachi Ltd | Magneto-optical reproducer |
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