JPS5547679A - Novel 4-alkyl-2-pyridyl-1-phthalazone derivative - Google Patents

Novel 4-alkyl-2-pyridyl-1-phthalazone derivative

Info

Publication number
JPS5547679A
JPS5547679A JP12038878A JP12038878A JPS5547679A JP S5547679 A JPS5547679 A JP S5547679A JP 12038878 A JP12038878 A JP 12038878A JP 12038878 A JP12038878 A JP 12038878A JP S5547679 A JPS5547679 A JP S5547679A
Authority
JP
Japan
Prior art keywords
pyridyl
formula
alkyl group
phthalazone
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12038878A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Masao Eguchi
Hiromichi Tanaka
Shigeru Ito
Yoshimi Takashima
Masahiko Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP12038878A priority Critical patent/JPS5547679A/en
Priority to US06/064,368 priority patent/US4293553A/en
Priority to CA000333350A priority patent/CA1135697A/en
Priority to AU49712/79A priority patent/AU4971279A/en
Priority to SE7906681A priority patent/SE7906681L/en
Priority to DE19792932259 priority patent/DE2932259A1/en
Priority to FR7920485A priority patent/FR2433017A1/en
Priority to IT25069/79A priority patent/IT1163698B/en
Priority to NL7906138A priority patent/NL7906138A/en
Priority to GB7927986A priority patent/GB2030136B/en
Publication of JPS5547679A publication Critical patent/JPS5547679A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 4-alkyl-2-pyridyl-1-phthalazone derivarive of formula I: (R1 and R2 are lower alkyl groups; R3 is straight or branched chain alkyl group; R4 is H or lower alkyl group; R5 is alkyl group).
EXAMPLE: 7-Ethoxycarbonyl-4,6,8-trimethyl-2-(2-pyridyl)-1-phthalazone.
USE: Drugs for arteriosclerosis, anti-thrombotics and anti-thromboxane agents, having anti-thromboxane and blood vessel smooth muscle relaxing actions, useful for preventing and treating thrombosis and arteriosclerosis.
PROCESS: One mole of a 3-hydroxy-3-alkylphthalide derivative of formula II is reacted with 1W5 moles of a pyridyl hydrozine derivative of formula III in a solvent, e.g. ethanol, under heating at 50W100°C to give the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP12038878A 1978-08-11 1978-10-02 Novel 4-alkyl-2-pyridyl-1-phthalazone derivative Pending JPS5547679A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP12038878A JPS5547679A (en) 1978-10-02 1978-10-02 Novel 4-alkyl-2-pyridyl-1-phthalazone derivative
US06/064,368 US4293553A (en) 1978-08-11 1979-08-07 1-Phthalazone derivatives, and use thereof
CA000333350A CA1135697A (en) 1978-08-11 1979-08-08 1-phthalazone derivatives, process for preparation thereof, and use thereof
AU49712/79A AU4971279A (en) 1978-08-11 1979-08-08 1-phthalazone derivatives
SE7906681A SE7906681L (en) 1978-08-11 1979-08-09 FTALAZONDERIVAT
DE19792932259 DE2932259A1 (en) 1978-08-11 1979-08-09 1-PHTHALAZONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
FR7920485A FR2433017A1 (en) 1978-08-11 1979-08-10 PHTALAZONE-1 DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM
IT25069/79A IT1163698B (en) 1978-08-11 1979-08-10 DERIVATIVES OF 1-FTALAZONE, PROCEDURE FOR THEIR PREPARATION, AND THEIR USE
NL7906138A NL7906138A (en) 1978-08-11 1979-08-10 1-PHTHALA DERIVATIVES, METHODS FOR PREPARING THE SAME, AND PHARMACEUTICAL PREPARATIONS CONTAINING THIS COMPOUND AS AN ACTIVE COMPONENT.
GB7927986A GB2030136B (en) 1978-08-11 1979-08-10 1-phthalazone derivatives and acid addition salts their preparation and compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12038878A JPS5547679A (en) 1978-10-02 1978-10-02 Novel 4-alkyl-2-pyridyl-1-phthalazone derivative

Publications (1)

Publication Number Publication Date
JPS5547679A true JPS5547679A (en) 1980-04-04

Family

ID=14784965

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12038878A Pending JPS5547679A (en) 1978-08-11 1978-10-02 Novel 4-alkyl-2-pyridyl-1-phthalazone derivative

Country Status (1)

Country Link
JP (1) JPS5547679A (en)

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