JPS5547657A - Fluorine contained 1*44dihydropyridine compound and medical use - Google Patents

Fluorine contained 1*44dihydropyridine compound and medical use

Info

Publication number
JPS5547657A
JPS5547657A JP12091179A JP12091179A JPS5547657A JP S5547657 A JPS5547657 A JP S5547657A JP 12091179 A JP12091179 A JP 12091179A JP 12091179 A JP12091179 A JP 12091179A JP S5547657 A JPS5547657 A JP S5547657A
Authority
JP
Japan
Prior art keywords
compound
medical use
fluorine contained
fluorine
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12091179A
Other languages
English (en)
Other versions
JPS6016934B2 (ja
Inventor
Horusutoman Hararuto
Bozaato Furiidoritsuhi
Haize Arento
Katsuda Sutanisurafu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of JPS5547657A publication Critical patent/JPS5547657A/ja
Publication of JPS6016934B2 publication Critical patent/JPS6016934B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP54120911A 1978-09-25 1979-09-21 フッ素含有１，４−ジヒドロピリジン化合物およびその製造方法 Expired JPS6016934B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782841667 DE2841667A1 (de) 1978-09-25 1978-09-25 Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2841667.3 1978-09-25

Publications (2)

Publication Number Publication Date
JPS5547657A true JPS5547657A (en) 1980-04-04
JPS6016934B2 JPS6016934B2 (ja) 1985-04-30

Family

ID=6050376

Family Applications (2)

Application Number Title Priority Date Filing Date
JP54120911A Expired JPS6016934B2 (ja) 1978-09-25 1979-09-21 フッ素含有１，４−ジヒドロピリジン化合物およびその製造方法
JP59155722A Granted JPS6069018A (ja) 1978-09-25 1984-07-27 フツ素含有１，４−ジヒドロピリジン化合物を含有する薬剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP59155722A Granted JPS6069018A (ja) 1978-09-25 1984-07-27 フツ素含有１，４−ジヒドロピリジン化合物を含有する薬剤

Country Status (15)

Country Link
US (1) US4256749A (ja)
EP (1) EP0009206B1 (ja)
JP (2) JPS6016934B2 (ja)
AT (1) ATE290T1 (ja)
CA (1) CA1130291A (ja)
DE (2) DE2841667A1 (ja)
DK (1) DK157013C (ja)
ES (1) ES484397A1 (ja)
FI (1) FI70887C (ja)
GR (1) GR74127B (ja)
HK (1) HK15184A (ja)
HU (1) HU178449B (ja)
IE (1) IE49462B1 (ja)
IL (1) IL58299A (ja)
SG (1) SG38783G (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5897333U (ja) * 1981-12-24 1983-07-02 株式会社昭和製作所 油圧緩衝器の減衰力調整機構
JPS5897332U (ja) * 1981-12-24 1983-07-02 株式会社昭和製作所 油圧緩衝器の減衰力調整機構
JPS62145064A (ja) * 1985-12-13 1987-06-29 バイエル・アクチエンゲゼルシヤフト 新規なフツ素含有１，４−ジヒドロピリジン類
JPS62292757A (ja) * 1986-06-12 1987-12-19 Taisho Pharmaceut Co Ltd １，４−ジヒドロピリジン誘導体
JPS63160458U (ja) * 1987-04-09 1988-10-20

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508446B1 (fr) * 1981-06-25 1986-05-02 Rhone Poulenc Agrochimie Herbicides a fonctions amide et ester derives de la pyridine ainsi que leur procede de preparation et leur application
DE3130041A1 (de) * 1981-07-30 1983-02-17 Bayer Ag, 5090 Leverkusen Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
DE3312283A1 (de) * 1983-04-05 1984-10-18 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern
DE3316510A1 (de) * 1983-05-06 1984-11-08 Bayer Ag Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen
US4677101A (en) * 1983-09-26 1987-06-30 Merck & Co., Inc. Substituted dihydroazepines useful as calcium channel blockers
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
EP0169009A3 (en) * 1984-07-17 1988-08-31 FISONS plc Novel dihydropyridine derivatives and their production, formulation and use as pharmaceuticals
US4868181A (en) * 1986-08-04 1989-09-19 E. I. Du Pont De Nemours And Company 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
US5177211A (en) * 1988-01-21 1993-01-05 Alter, S.A. 4-alkyl-1,4-dihydropyridines with PAF-antagonist activity
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
EP0330470A3 (en) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. 1,4-dihydropyridine derivatives useful against tumour cells
DE3833893A1 (de) * 1988-10-05 1990-04-12 Bayer Ag Verwendung von basischen nitro-phenyl-dihydropyridin-amiden als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung ueber neue zwischenprodukte
JP3040364U (ja) * 1996-07-23 1997-08-19 清秀 中川 芳香含有物質の詰め替え可能な枕

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5897333U (ja) * 1981-12-24 1983-07-02 株式会社昭和製作所 油圧緩衝器の減衰力調整機構
JPS5897332U (ja) * 1981-12-24 1983-07-02 株式会社昭和製作所 油圧緩衝器の減衰力調整機構
JPS6221165Y2 (ja) * 1981-12-24 1987-05-29
JPS62145064A (ja) * 1985-12-13 1987-06-29 バイエル・アクチエンゲゼルシヤフト 新規なフツ素含有１，４−ジヒドロピリジン類
JPS62292757A (ja) * 1986-06-12 1987-12-19 Taisho Pharmaceut Co Ltd １，４−ジヒドロピリジン誘導体
JPS63160458U (ja) * 1987-04-09 1988-10-20

Also Published As

Publication number Publication date
IL58299A (en) 1983-03-31
DK157013C (da) 1990-03-26
ATE290T1 (de) 1981-10-15
DE2841667A1 (de) 1980-04-10
DK399079A (da) 1980-03-26
JPS6069018A (ja) 1985-04-19
GR74127B (ja) 1984-06-06
IE791802L (en) 1980-03-25
EP0009206A3 (en) 1980-04-16
SG38783G (en) 1984-07-27
IE49462B1 (en) 1985-10-16
DE2961012D1 (en) 1981-12-24
JPS6016934B2 (ja) 1985-04-30
HU178449B (en) 1982-05-28
FI70887B (fi) 1986-07-18
JPS6217972B2 (ja) 1987-04-21
EP0009206A2 (de) 1980-04-02
US4256749A (en) 1981-03-17
CA1130291A (en) 1982-08-24
EP0009206B1 (de) 1981-10-14
FI792939A (fi) 1980-03-26
FI70887C (fi) 1986-10-27
HK15184A (en) 1984-03-02
DK157013B (da) 1989-10-30
ES484397A1 (es) 1980-05-16
IL58299A0 (en) 1979-12-30

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