JPS5538362A - Optically acitive thiol ester derivative and its preparation - Google Patents

Optically acitive thiol ester derivative and its preparation

Info

Publication number
JPS5538362A
JPS5538362A JP11339778A JP11339778A JPS5538362A JP S5538362 A JPS5538362 A JP S5538362A JP 11339778 A JP11339778 A JP 11339778A JP 11339778 A JP11339778 A JP 11339778A JP S5538362 A JPS5538362 A JP S5538362A
Authority
JP
Japan
Prior art keywords
formula
compound
preparation
thiol ester
optically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11339778A
Other languages
Japanese (ja)
Inventor
Tetsuro Yokobe
Tsutomu Yamanaka
Mitsuharu Sano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP11339778A priority Critical patent/JPS5538362A/en
Publication of JPS5538362A publication Critical patent/JPS5538362A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Thiol ester derivatives of formula I and II (X is methylene, S) and their salts.
EXAMPLE: 3-l-menthoxyacetylthio-2-methylpropionic acid.
USE: Synthetic intermediate of antihypertensive. The optically active compound of formula III useful as hypotensor can readily derived. These compounds have the activity inhibiting the enzyme transforming angiotensin I. The compound of formula I is used as a remedy for inflammation and liver disorder and the compound of formula II is used as hypotensor.
PREPARATION: The reaction of 1-menthoxyacetic acid with racemic 3-mercapto-2- methylpropionic acid gives the compound of formula I, of which one diastereoisomer or its reactive derivative is reacted with the compound of formula IV or its salt to form the compound of formula II or its salt. The reaction is carried out in a solvent in the presence of a condensation reagent or base.
COPYRIGHT: (C)1980,JPO&Japio
JP11339778A 1978-09-13 1978-09-13 Optically acitive thiol ester derivative and its preparation Pending JPS5538362A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11339778A JPS5538362A (en) 1978-09-13 1978-09-13 Optically acitive thiol ester derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11339778A JPS5538362A (en) 1978-09-13 1978-09-13 Optically acitive thiol ester derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5538362A true JPS5538362A (en) 1980-03-17

Family

ID=14611256

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11339778A Pending JPS5538362A (en) 1978-09-13 1978-09-13 Optically acitive thiol ester derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5538362A (en)

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