JPS5538362A - Optically acitive thiol ester derivative and its preparation - Google Patents
Optically acitive thiol ester derivative and its preparationInfo
- Publication number
- JPS5538362A JPS5538362A JP11339778A JP11339778A JPS5538362A JP S5538362 A JPS5538362 A JP S5538362A JP 11339778 A JP11339778 A JP 11339778A JP 11339778 A JP11339778 A JP 11339778A JP S5538362 A JPS5538362 A JP S5538362A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- preparation
- thiol ester
- optically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Thiol ester derivatives of formula I and II (X is methylene, S) and their salts.
EXAMPLE: 3-l-menthoxyacetylthio-2-methylpropionic acid.
USE: Synthetic intermediate of antihypertensive. The optically active compound of formula III useful as hypotensor can readily derived. These compounds have the activity inhibiting the enzyme transforming angiotensin I. The compound of formula I is used as a remedy for inflammation and liver disorder and the compound of formula II is used as hypotensor.
PREPARATION: The reaction of 1-menthoxyacetic acid with racemic 3-mercapto-2- methylpropionic acid gives the compound of formula I, of which one diastereoisomer or its reactive derivative is reacted with the compound of formula IV or its salt to form the compound of formula II or its salt. The reaction is carried out in a solvent in the presence of a condensation reagent or base.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11339778A JPS5538362A (en) | 1978-09-13 | 1978-09-13 | Optically acitive thiol ester derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11339778A JPS5538362A (en) | 1978-09-13 | 1978-09-13 | Optically acitive thiol ester derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5538362A true JPS5538362A (en) | 1980-03-17 |
Family
ID=14611256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11339778A Pending JPS5538362A (en) | 1978-09-13 | 1978-09-13 | Optically acitive thiol ester derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5538362A (en) |
-
1978
- 1978-09-13 JP JP11339778A patent/JPS5538362A/en active Pending
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