JPS5527143A - Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazole - Google Patents

Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazole

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Publication number
JPS5527143A
JPS5527143A JP9951978A JP9951978A JPS5527143A JP S5527143 A JPS5527143 A JP S5527143A JP 9951978 A JP9951978 A JP 9951978A JP 9951978 A JP9951978 A JP 9951978A JP S5527143 A JPS5527143 A JP S5527143A
Authority
JP
Japan
Prior art keywords
imidazo
thiazole
lower alkyl
tetrahydronaphtho
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9951978A
Other languages
Japanese (ja)
Inventor
Yasukata Shikayama
Takeshi Hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP9951978A priority Critical patent/JPS5527143A/en
Publication of JPS5527143A publication Critical patent/JPS5527143A/en
Pending legal-status Critical Current

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A tetrahydronaphtho[1',2':4,5]imidazo[2,1-b]thiazole of formulaIand its hydrohalogenide of formulaII: (R1 is H or lower alkyl group; R2 is lower alkyl, phenyl group, etc.; X is halogen; ring A may be substituted by lower alkyl or alkoxy, group etc.; rings B and C may be cis or trans forms).
EXAMPLE: Trans-5,6,6a, 11a-tetrahydro-8-phenylaphtho[1',2':4,5]imidazo-[2,1-b] thiazole.
USE: Medicines, particularly anti-inflammatory drugs.
PROCESS: A novel compound of formula III is reacted with an α-haloketone of formula IV in a solvent, e.g. acetic or n-propionic acid, to give a compound of formula II, which is treated with an aqueous NaHCO3 or ammonia to form the compound of formulaI.
COPYRIGHT: (C)1980,JPO&Japio
JP9951978A 1978-08-17 1978-08-17 Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazole Pending JPS5527143A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9951978A JPS5527143A (en) 1978-08-17 1978-08-17 Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9951978A JPS5527143A (en) 1978-08-17 1978-08-17 Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazole

Publications (1)

Publication Number Publication Date
JPS5527143A true JPS5527143A (en) 1980-02-27

Family

ID=14249486

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9951978A Pending JPS5527143A (en) 1978-08-17 1978-08-17 Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazole

Country Status (1)

Country Link
JP (1) JPS5527143A (en)

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