JPS5527143A - Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazole - Google Patents
Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazoleInfo
- Publication number
- JPS5527143A JPS5527143A JP9951978A JP9951978A JPS5527143A JP S5527143 A JPS5527143 A JP S5527143A JP 9951978 A JP9951978 A JP 9951978A JP 9951978 A JP9951978 A JP 9951978A JP S5527143 A JPS5527143 A JP S5527143A
- Authority
- JP
- Japan
- Prior art keywords
- imidazo
- thiazole
- lower alkyl
- tetrahydronaphtho
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A tetrahydronaphtho[1',2':4,5]imidazo[2,1-b]thiazole of formulaIand its hydrohalogenide of formulaII: (R1 is H or lower alkyl group; R2 is lower alkyl, phenyl group, etc.; X is halogen; ring A may be substituted by lower alkyl or alkoxy, group etc.; rings B and C may be cis or trans forms).
EXAMPLE: Trans-5,6,6a, 11a-tetrahydro-8-phenylaphtho[1',2':4,5]imidazo-[2,1-b] thiazole.
USE: Medicines, particularly anti-inflammatory drugs.
PROCESS: A novel compound of formula III is reacted with an α-haloketone of formula IV in a solvent, e.g. acetic or n-propionic acid, to give a compound of formula II, which is treated with an aqueous NaHCO3 or ammonia to form the compound of formulaI.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9951978A JPS5527143A (en) | 1978-08-17 | 1978-08-17 | Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9951978A JPS5527143A (en) | 1978-08-17 | 1978-08-17 | Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazole |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5527143A true JPS5527143A (en) | 1980-02-27 |
Family
ID=14249486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9951978A Pending JPS5527143A (en) | 1978-08-17 | 1978-08-17 | Preparation of tetrahydronaphtho (1',2':4,5) imidazo (2,1-b) thiazole |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5527143A (en) |
-
1978
- 1978-08-17 JP JP9951978A patent/JPS5527143A/en active Pending
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