JPS552603A - Separation of protamine - Google Patents
Separation of protamineInfo
- Publication number
- JPS552603A JPS552603A JP7374378A JP7374378A JPS552603A JP S552603 A JPS552603 A JP S552603A JP 7374378 A JP7374378 A JP 7374378A JP 7374378 A JP7374378 A JP 7374378A JP S552603 A JPS552603 A JP S552603A
- Authority
- JP
- Japan
- Prior art keywords
- salt
- protamine
- mineral acid
- double decomposition
- milt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
PURPOSE: To prepare mineral acid salts of protamino, e.g., an enzyme stabilizer or an activator, e.g., an antibiotic, simply and economically, by converting a protamine extract obtained from a milt of fish into its condevred phosphate, which is subjected to double decomposition by a highly concentrated inorganic salt.
CONSTITUTION: A protamine extracted liquid obtained from a milt of fish containing protamin is reacted with condensed phosphoric acid or its salt to make a slight soluble salt which is precipitated. This salt is then subjected to double decomposition by a highly concentrated inorganic salt to give earily a mineral acid salt of protamine. The conventional methods have fault in coverting the condensed phosphate of protamine into the mineral acid salt. An alkaline (earther ) salt of mineral acid may be used as the inorganic salt for double decomposition.
USE: Insulin pharmaceutical preparation having prolonged effectiveness consisting of a composite of insulin, a protamine parenteral solution of an antiheparin, biochemical separation, and medicines for purification.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53073743A JPS5949238B2 (en) | 1978-06-20 | 1978-06-20 | How to separate protamine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53073743A JPS5949238B2 (en) | 1978-06-20 | 1978-06-20 | How to separate protamine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS552603A true JPS552603A (en) | 1980-01-10 |
JPS5949238B2 JPS5949238B2 (en) | 1984-12-01 |
Family
ID=13527018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53073743A Expired JPS5949238B2 (en) | 1978-06-20 | 1978-06-20 | How to separate protamine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5949238B2 (en) |
-
1978
- 1978-06-20 JP JP53073743A patent/JPS5949238B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5949238B2 (en) | 1984-12-01 |
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