JPS5517302A - New derivative of disulfide - Google Patents

New derivative of disulfide

Info

Publication number
JPS5517302A
JPS5517302A JP8590078A JP8590078A JPS5517302A JP S5517302 A JPS5517302 A JP S5517302A JP 8590078 A JP8590078 A JP 8590078A JP 8590078 A JP8590078 A JP 8590078A JP S5517302 A JPS5517302 A JP S5517302A
Authority
JP
Japan
Prior art keywords
formula
compound
group
derivative
carboxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8590078A
Other languages
Japanese (ja)
Other versions
JPS6058232B2 (en
Inventor
Tadayo Fujii
Nobuaki Nakagawa
Kikuo Kotani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP53085900A priority Critical patent/JPS6058232B2/en
Priority to FR7918007A priority patent/FR2430943A1/en
Priority to GB7924336A priority patent/GB2029825B/en
Priority to DE19792928384 priority patent/DE2928384A1/en
Priority to US06/057,502 priority patent/US4258193A/en
Priority to SE7906233A priority patent/SE448095B/en
Publication of JPS5517302A publication Critical patent/JPS5517302A/en
Publication of JPS6058232B2 publication Critical patent/JPS6058232B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/76—Sulfur atoms attached to a second hetero atom
    • C07D277/78—Sulfur atoms attached to a second hetero atom to a second sulphur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyamides (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A disulfide derivative of formula I ( R1 = 2-benzothiazolyl, 2-pyridyl-N-oxide; R2 = alkylene which may have a free or protected functional group; R3 = amino acid, carboxyl residue of lower polypeptides; R4 = carboxyl, its reactive derivative, protected carboxyl, imidate; n=0, 1).
EXAMPLE: 3-(Benzothiazol-2'-yldithio)propionic acid of formula V.
USE: Thiol-introducing reagent and crosslinking reagent having extremely high S-S exchange reactivity.
PROCESS: A compound of formula IV is obtained by the reaction of a compound of formula II with a compound of thiolcarboxylic acid of formula III (R5=the same group as R3, a group which can be converted to an imidate group) or its derivative. The compound obtained is converted to a compound of formula I if necessary.
COPYRIGHT: (C)1980,JPO&Japio
JP53085900A 1978-07-13 1978-07-13 Novel disulfide derivative Expired JPS6058232B2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP53085900A JPS6058232B2 (en) 1978-07-13 1978-07-13 Novel disulfide derivative
FR7918007A FR2430943A1 (en) 1978-07-13 1979-07-11 NEW DISULFIDE DERIVATIVES
GB7924336A GB2029825B (en) 1978-07-13 1979-07-12 Benzothiazolyl and pyndyl n oxide disulphide derivatives
DE19792928384 DE2928384A1 (en) 1978-07-13 1979-07-13 DISULFID DERIVATIVES
US06/057,502 US4258193A (en) 1978-07-13 1979-07-13 Disulfide derivatives having S--S exchange reactivity
SE7906233A SE448095B (en) 1978-07-13 1979-07-19 disulfide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53085900A JPS6058232B2 (en) 1978-07-13 1978-07-13 Novel disulfide derivative

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP16491178A Division JPS5522657A (en) 1978-07-13 1978-12-28 Reactive compound
JP16490978A Division JPS5512178A (en) 1978-04-28 1978-12-28 Carrier having s-s exchange reactivity

Publications (2)

Publication Number Publication Date
JPS5517302A true JPS5517302A (en) 1980-02-06
JPS6058232B2 JPS6058232B2 (en) 1985-12-19

Family

ID=13871729

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53085900A Expired JPS6058232B2 (en) 1978-07-13 1978-07-13 Novel disulfide derivative

Country Status (2)

Country Link
JP (1) JPS6058232B2 (en)
SE (1) SE448095B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58500480A (en) * 1981-04-06 1983-03-31 フア−マシア・アクチエボラ−グ therapeutically active compounds
JPS58500482A (en) * 1981-04-06 1983-03-31 フア−マシア・アクチエボラ−グ Therapeutically active compounds and pharmaceutical compositions containing them
JPS5880558A (en) * 1981-11-09 1983-05-14 Sekisui Chem Co Ltd Immunochemical measuring reagent
JPS6391563A (en) * 1986-10-07 1988-04-22 Nitsusui Seiyaku Kk Examination of protein specific antigen derived from bacteria
JP2008512540A (en) * 2004-09-09 2008-04-24 アクバイオ・リミテッド Assay methods, materials and manufacturing
JP2011519864A (en) * 2008-04-30 2011-07-14 イミュノジェン・インコーポレーテッド Crosslinkers and their use

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62269738A (en) * 1986-05-19 1987-11-24 Hitachi Ltd Bearing device

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58500480A (en) * 1981-04-06 1983-03-31 フア−マシア・アクチエボラ−グ therapeutically active compounds
JPS58500482A (en) * 1981-04-06 1983-03-31 フア−マシア・アクチエボラ−グ Therapeutically active compounds and pharmaceutical compositions containing them
JPS5880558A (en) * 1981-11-09 1983-05-14 Sekisui Chem Co Ltd Immunochemical measuring reagent
JPH0123064B2 (en) * 1981-11-09 1989-04-28 Sekisui Kagaku Kogyo Kk
JPS6391563A (en) * 1986-10-07 1988-04-22 Nitsusui Seiyaku Kk Examination of protein specific antigen derived from bacteria
JP2008512540A (en) * 2004-09-09 2008-04-24 アクバイオ・リミテッド Assay methods, materials and manufacturing
JP2011519864A (en) * 2008-04-30 2011-07-14 イミュノジェン・インコーポレーテッド Crosslinkers and their use

Also Published As

Publication number Publication date
SE7906233L (en) 1981-01-20
JPS6058232B2 (en) 1985-12-19
SE448095B (en) 1987-01-19

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