JPS5515432A - Lactam compound - Google Patents

Lactam compound

Info

Publication number
JPS5515432A
JPS5515432A JP8753378A JP8753378A JPS5515432A JP S5515432 A JPS5515432 A JP S5515432A JP 8753378 A JP8753378 A JP 8753378A JP 8753378 A JP8753378 A JP 8753378A JP S5515432 A JPS5515432 A JP S5515432A
Authority
JP
Japan
Prior art keywords
compound
formula
alkyl
acyl
phenyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8753378A
Other languages
Japanese (ja)
Other versions
JPS6245863B2 (en
Inventor
Masayuki Imanishi
Yutaka Masuoka
Ryoko Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP8753378A priority Critical patent/JPS5515432A/en
Priority to AU40242/78A priority patent/AU518986B2/en
Priority to DK439878A priority patent/DK439878A/en
Priority to CA312,844A priority patent/CA1102338A/en
Priority to DE7878101094T priority patent/DE2861210D1/en
Priority to EP78101094A priority patent/EP0001601B1/en
Priority to IT28617/78A priority patent/IT1099358B/en
Priority to NO783420A priority patent/NO150041C/en
Priority to US05/950,524 priority patent/US4198514A/en
Publication of JPS5515432A publication Critical patent/JPS5515432A/en
Publication of JPS6245863B2 publication Critical patent/JPS6245863B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A lactam compound of formula I (R1 is H, acyl, alkoxycarbonyl, dialkylamino alkyl, or alkyl group; R2 is H,acyl, or alkoxy carbonyl group; R3 is H, alkyl, or phenyl group; R4 is phenyl group; n is 1 or 2).
EXAMPLE: 4-(4-chlorobenzyl)-2-pyrrolidinone.
USE: Useful as an anti-anxiety drug having very weak hypnotic and myotatic actions, e.g. a remedy for psychosomatic diseases or anxiety neuroses, such as autonomic imbalance, nervous vomiting, dermatitis neurotica, and having an antispastic action effective against epilepy or traumatic spasm.
PROCESS: A compound of formula II is reduced in the presence of a mineral acid to give a compound of formula III, which is subjected to ring closure in the presence of a base, e.g. NaOH, in a suitable solvent to form the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP8753378A 1977-10-11 1978-07-17 Lactam compound Granted JPS5515432A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP8753378A JPS5515432A (en) 1978-07-17 1978-07-17 Lactam compound
AU40242/78A AU518986B2 (en) 1977-10-11 1978-09-27 Lactams
DK439878A DK439878A (en) 1977-10-11 1978-10-04 PROCEDURE FOR PREPARING LACTAM COMPOUNDS
CA312,844A CA1102338A (en) 1977-10-11 1978-10-06 Lactam compounds
DE7878101094T DE2861210D1 (en) 1977-10-11 1978-10-07 Lactam compounds and methods for their preparation
EP78101094A EP0001601B1 (en) 1977-10-11 1978-10-07 Lactam compounds and methods for their preparation
IT28617/78A IT1099358B (en) 1977-10-11 1978-10-10 ANSIOLYTIC ACTION LACTAMIC COMPOUNDS
NO783420A NO150041C (en) 1977-10-11 1978-10-10 ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE LACTAM COMPOUNDS
US05/950,524 US4198514A (en) 1977-10-11 1978-10-11 Lactam compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8753378A JPS5515432A (en) 1978-07-17 1978-07-17 Lactam compound

Publications (2)

Publication Number Publication Date
JPS5515432A true JPS5515432A (en) 1980-02-02
JPS6245863B2 JPS6245863B2 (en) 1987-09-29

Family

ID=13917619

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8753378A Granted JPS5515432A (en) 1977-10-11 1978-07-17 Lactam compound

Country Status (1)

Country Link
JP (1) JPS5515432A (en)

Also Published As

Publication number Publication date
JPS6245863B2 (en) 1987-09-29

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