JPS55153799A - Preparation of 3alpha-hydroxy-keto-cholanic acid - Google Patents
Preparation of 3alpha-hydroxy-keto-cholanic acidInfo
- Publication number
- JPS55153799A JPS55153799A JP6150080A JP6150080A JPS55153799A JP S55153799 A JPS55153799 A JP S55153799A JP 6150080 A JP6150080 A JP 6150080A JP 6150080 A JP6150080 A JP 6150080A JP S55153799 A JPS55153799 A JP S55153799A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- keto
- hydroxy
- cholanic acid
- 3alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
PURPOSE: To obtain a 3α-hydroxy-keto-cholanic acid useful as an intermediate for the synthesis of medicines in high yield and purity, by oxidizing a hydroxycholanic acid with bromocarbamide.
CONSTITUTION: A hydroxycholanic acid of formula I (R1 and R2 are OH, or either of them is OH, and the other is H), e.g. 3α,7α-dihydroxycholanic acid, cholic acid and 3α,12α-dihydroxycholanic acid, is oxidized with bromocarbamide to give a 3α-hydroxy-keto-cholanic acid of formula II (R1' and R2' are H when R1 and R2 are H, and oxo when R1 and R2 are OH), e.g. 3α-hydroxy-7-keto-cholanic acid or 3α-hydroxy-12-keto-cholanic acid. Preferably, the bromocarbamide is used in an amount of 1W3mol per OH group to be oxidized.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6150080A JPS55153799A (en) | 1980-05-09 | 1980-05-09 | Preparation of 3alpha-hydroxy-keto-cholanic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6150080A JPS55153799A (en) | 1980-05-09 | 1980-05-09 | Preparation of 3alpha-hydroxy-keto-cholanic acid |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1226077A Division JPS5398950A (en) | 1977-02-07 | 1977-02-07 | Process for preparing ketocholanes or ester thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55153799A true JPS55153799A (en) | 1980-11-29 |
Family
ID=13172867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6150080A Pending JPS55153799A (en) | 1980-05-09 | 1980-05-09 | Preparation of 3alpha-hydroxy-keto-cholanic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55153799A (en) |
-
1980
- 1980-05-09 JP JP6150080A patent/JPS55153799A/en active Pending
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