JPS55153799A - Preparation of 3alpha-hydroxy-keto-cholanic acid - Google Patents

Preparation of 3alpha-hydroxy-keto-cholanic acid

Info

Publication number
JPS55153799A
JPS55153799A JP6150080A JP6150080A JPS55153799A JP S55153799 A JPS55153799 A JP S55153799A JP 6150080 A JP6150080 A JP 6150080A JP 6150080 A JP6150080 A JP 6150080A JP S55153799 A JPS55153799 A JP S55153799A
Authority
JP
Japan
Prior art keywords
acid
keto
hydroxy
cholanic acid
3alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6150080A
Other languages
Japanese (ja)
Inventor
Mikio Hori
Yutaka Imai
Manzou Itou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amano Enzyme Inc
Original Assignee
Amano Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amano Pharmaceutical Co Ltd filed Critical Amano Pharmaceutical Co Ltd
Priority to JP6150080A priority Critical patent/JPS55153799A/en
Publication of JPS55153799A publication Critical patent/JPS55153799A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To obtain a 3α-hydroxy-keto-cholanic acid useful as an intermediate for the synthesis of medicines in high yield and purity, by oxidizing a hydroxycholanic acid with bromocarbamide.
CONSTITUTION: A hydroxycholanic acid of formula I (R1 and R2 are OH, or either of them is OH, and the other is H), e.g. 3α,7α-dihydroxycholanic acid, cholic acid and 3α,12α-dihydroxycholanic acid, is oxidized with bromocarbamide to give a 3α-hydroxy-keto-cholanic acid of formula II (R1' and R2' are H when R1 and R2 are H, and oxo when R1 and R2 are OH), e.g. 3α-hydroxy-7-keto-cholanic acid or 3α-hydroxy-12-keto-cholanic acid. Preferably, the bromocarbamide is used in an amount of 1W3mol per OH group to be oxidized.
COPYRIGHT: (C)1980,JPO&Japio
JP6150080A 1980-05-09 1980-05-09 Preparation of 3alpha-hydroxy-keto-cholanic acid Pending JPS55153799A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6150080A JPS55153799A (en) 1980-05-09 1980-05-09 Preparation of 3alpha-hydroxy-keto-cholanic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6150080A JPS55153799A (en) 1980-05-09 1980-05-09 Preparation of 3alpha-hydroxy-keto-cholanic acid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP1226077A Division JPS5398950A (en) 1977-02-07 1977-02-07 Process for preparing ketocholanes or ester thereof

Publications (1)

Publication Number Publication Date
JPS55153799A true JPS55153799A (en) 1980-11-29

Family

ID=13172867

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6150080A Pending JPS55153799A (en) 1980-05-09 1980-05-09 Preparation of 3alpha-hydroxy-keto-cholanic acid

Country Status (1)

Country Link
JP (1) JPS55153799A (en)

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