JPS5659737A - Preparation of hydroxycholesta-5,7-diene - Google Patents

Preparation of hydroxycholesta-5,7-diene

Info

Publication number
JPS5659737A
JPS5659737A JP13587179A JP13587179A JPS5659737A JP S5659737 A JPS5659737 A JP S5659737A JP 13587179 A JP13587179 A JP 13587179A JP 13587179 A JP13587179 A JP 13587179A JP S5659737 A JPS5659737 A JP S5659737A
Authority
JP
Japan
Prior art keywords
hydroxycholest
ene
group
hydroxycholesta
diene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13587179A
Other languages
Japanese (ja)
Other versions
JPS6145999B2 (en
Inventor
Osamu Nishikawa
Kenji Ishimaru
Toru Takeshita
Hideki Tsuruta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP13587179A priority Critical patent/JPS5659737A/en
Priority to EP80303732A priority patent/EP0028484B1/en
Priority to DE8080303732T priority patent/DE3070985D1/en
Priority to CA000362937A priority patent/CA1160217A/en
Priority to DK447380A priority patent/DK160817C/en
Publication of JPS5659737A publication Critical patent/JPS5659737A/en
Priority to US06/371,870 priority patent/US4388243A/en
Publication of JPS6145999B2 publication Critical patent/JPS6145999B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: To obtain the titled compound which is an intermediate for active vitamin D3 in high yield, by using a hydroxycholest-5-ene wherein the hydroxyl group is protected with a specific protective group as a raw material.
CONSTITUTION: A hydroxycholest-5-ene of formula I (R1 and R2 are lower alkoxycarbonyl groups; R3 and R4 are Hs or lower alkoxycarbonyloxy groups) is reacted with a brominating agent capable of brominating the allyl position and then a dehydrobrominating agent to give a hydroxycholesta-5,7-diene of formula II. The hydroxyl group of the hydroxycholest-5-ene protected with a lower alkoxycarbonyl group, e.g. ethoxycarbonyl group, reduces the formation of by-products and facilitates the separation and purification.
COPYRIGHT: (C)1981,JPO&Japio
JP13587179A 1979-10-23 1979-10-23 Preparation of hydroxycholesta-5,7-diene Granted JPS5659737A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP13587179A JPS5659737A (en) 1979-10-23 1979-10-23 Preparation of hydroxycholesta-5,7-diene
EP80303732A EP0028484B1 (en) 1979-10-23 1980-10-22 Process for the preparation of active-type vitamin d3 compounds and of the cholesta-5,7-diene precursors, and products so obtained
DE8080303732T DE3070985D1 (en) 1979-10-23 1980-10-22 Process for the preparation of active-type vitamin d3 compounds and of the cholesta-5,7-diene precursors, and products so obtained
CA000362937A CA1160217A (en) 1979-10-23 1980-10-22 Process for the preparation of active-type vitamin d.sub.3 compounds
DK447380A DK160817C (en) 1979-10-23 1980-10-22 PROCEDURE FOR THE PREPARATION OF VITAMIN D3 COMPOUNDS
US06/371,870 US4388243A (en) 1979-10-23 1982-04-26 Process for the preparation of active-type vitamin D3 compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13587179A JPS5659737A (en) 1979-10-23 1979-10-23 Preparation of hydroxycholesta-5,7-diene

Publications (2)

Publication Number Publication Date
JPS5659737A true JPS5659737A (en) 1981-05-23
JPS6145999B2 JPS6145999B2 (en) 1986-10-11

Family

ID=15161711

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13587179A Granted JPS5659737A (en) 1979-10-23 1979-10-23 Preparation of hydroxycholesta-5,7-diene

Country Status (1)

Country Link
JP (1) JPS5659737A (en)

Also Published As

Publication number Publication date
JPS6145999B2 (en) 1986-10-11

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