JPS55147271A - Spiro compound and its preparation - Google Patents
Spiro compound and its preparationInfo
- Publication number
- JPS55147271A JPS55147271A JP5508279A JP5508279A JPS55147271A JP S55147271 A JPS55147271 A JP S55147271A JP 5508279 A JP5508279 A JP 5508279A JP 5508279 A JP5508279 A JP 5508279A JP S55147271 A JPS55147271 A JP S55147271A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- antiphlogistic
- lower alkyl
- preparation
- spiro compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
NEW MATERIAL:A spiro compound I (R is H or lower alkyl; R' is lower alkyl; R and R' may together with the adjacent N atom form a cyclic amino group).
EXAMPLE: 7-Methylaminospiro[benzo(b)furan-2(3H),1'-cyclopropan]-3-one.
USE: It has gastric juice secretion suppressing, antiphlogistic, analgesic actions, etc. for mammals, and is useful as an antiulcer, antiphlogistic, analgesic agents, etc. effective to diseases, e.g. peptic ulcer, duodenal ulcer, acute and chronic gastritis, lumbago, arthritis, etc. Applicable by oral administration.
PROCESS: For example, the compound I is prepared by catalytically reducing the compound II at 10W100°C in the presence of a carbonyl compound (e.g. formaldehyde, acetaldehyde, etc.) and a catalyst (e.g. platinum oxide), or by alkylating the compound III.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5508279A JPS55147271A (en) | 1979-05-04 | 1979-05-04 | Spiro compound and its preparation |
US06/115,548 US4284644A (en) | 1977-01-12 | 1980-01-25 | Spirobenzofuranone compounds |
GR61757A GR66729B (en) | 1979-05-04 | 1980-04-23 | |
ZA00802541A ZA802541B (en) | 1979-05-04 | 1980-04-28 | Spirobenzofuranones, their production and use |
DK184680A DK153551C (en) | 1979-05-04 | 1980-04-29 | METHOD OF ANALOGY FOR THE PREPARATION OF SPIROBENZOFURANONE COMPOUNDS OR SALTS THEREOF WITH INORGANIC OR ORGANIC ACIDS OR ALKALIMETALS |
AU57903/80A AU534940B2 (en) | 1979-05-04 | 1980-04-30 | Spirobenzofuranones |
DE8181104398T DE3067491D1 (en) | 1979-05-04 | 1980-05-01 | 7-ACETYL SPIROBENZOFURANONE COMPOUND |
CA000351051A CA1150287A (en) | 1979-05-04 | 1980-05-01 | Spirobenzofuranones, their production and use |
DE8181104399T DE3068085D1 (en) | 1979-05-04 | 1980-05-01 | SPIROBENZOFURANONE COMPOUNDS |
EP81104399A EP0039091B1 (en) | 1979-05-04 | 1980-05-01 | Spirobenzofuranone compounds |
EP80301431A EP0018830B1 (en) | 1979-05-04 | 1980-05-01 | Spirobenzofuranones, their production and pharmaceutical compositions containing them |
EP81104398A EP0038576B1 (en) | 1979-05-04 | 1980-05-01 | 7-acetylspirobenzofuranone compound |
DE8080301431T DE3063660D1 (en) | 1979-05-04 | 1980-05-01 | Spirobenzofuranones, their production and pharmaceutical compositions containing them |
AT470181A AT380018B (en) | 1979-05-04 | 1980-05-02 | METHOD FOR PRODUCING THE NEW 7-ACETYL SPIRO (BENZO (B) FURAN-2 (3H), 1'-CYCLOPROPAN) -3-ONS |
AT0233880A AT383122B (en) | 1979-05-04 | 1980-05-02 | METHOD FOR PRODUCING NEW SPIROBENZOFURANONE COMPOUNDS |
NO801290A NO155053C (en) | 1979-05-04 | 1980-05-02 | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE SPIROBENZOFURANON COMPOUNDS. |
ES491150A ES8104996A1 (en) | 1979-05-04 | 1980-05-03 | Spirobenzofuranones, their production and pharmaceutical compositions containing them. |
SU802917050A SU1022658A3 (en) | 1979-05-04 | 1980-05-05 | Method of producing spirobenzofurans |
ES497669A ES497669A0 (en) | 1979-05-04 | 1980-12-12 | A PROCEDURE FOR PRODUCING SPIROBENZOFU-RANONA COMPOUNDS |
US06/257,316 US4342779A (en) | 1977-12-27 | 1981-04-17 | 7-Acetylspirobenzofuranone compound |
ES502178A ES502178A0 (en) | 1979-05-04 | 1981-05-13 | A PROCEDURE FOR OBTAINING A SPIROBENZOFU-RANONA COMPOUND |
ES502179A ES502179A0 (en) | 1979-05-04 | 1981-05-13 | A PROCEDURE FOR OBTAINING 7-ACETYLESPIRE (BENZO (B) FURAN-2 (3H) -1'-CYCLOPROPANE) -3-ONA |
NO811787A NO154838C (en) | 1979-05-04 | 1981-05-26 | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE SPIROBENZOFURANON COMPOUNDS. |
NO811788A NO154839C (en) | 1979-05-04 | 1981-05-26 | ANALOGUE PROCEDURE FOR PREPARING A 7-ACETYL PIROBENZOFURANONE COMPOUND WITH THERAPEUTIC ACTIVITY. |
DK344881A DK344881A (en) | 1979-05-04 | 1981-08-03 | METHOD FOR PREPARING 7-ACETYLPIRO (BENZO (B) FURAN-2 (3H), 1! -CYCLOPROPAN) -3-ON. |
DK344781A DK344781A (en) | 1979-05-04 | 1981-08-03 | PROCEDURE FOR PREPARING SPIROBENZOFURANONE COMPOUNDS |
CA000394405A CA1138469A (en) | 1979-05-04 | 1982-01-18 | Spirobenzofuranones, their production and use |
CA000394406A CA1140562A (en) | 1979-05-04 | 1982-01-18 | Spirobenzofuranones, their production and use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5508279A JPS55147271A (en) | 1979-05-04 | 1979-05-04 | Spiro compound and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55147271A true JPS55147271A (en) | 1980-11-17 |
Family
ID=12988780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5508279A Pending JPS55147271A (en) | 1977-01-12 | 1979-05-04 | Spiro compound and its preparation |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS55147271A (en) |
ZA (1) | ZA802541B (en) |
-
1979
- 1979-05-04 JP JP5508279A patent/JPS55147271A/en active Pending
-
1980
- 1980-04-28 ZA ZA00802541A patent/ZA802541B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA802541B (en) | 1981-05-27 |
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