JPS55147271A - Spiro compound and its preparation - Google Patents

Spiro compound and its preparation

Info

Publication number
JPS55147271A
JPS55147271A JP5508279A JP5508279A JPS55147271A JP S55147271 A JPS55147271 A JP S55147271A JP 5508279 A JP5508279 A JP 5508279A JP 5508279 A JP5508279 A JP 5508279A JP S55147271 A JPS55147271 A JP S55147271A
Authority
JP
Japan
Prior art keywords
compound
antiphlogistic
lower alkyl
preparation
spiro compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5508279A
Other languages
Japanese (ja)
Inventor
Hirosada Sugihara
Masazumi Watanabe
Mitsuru Kawada
Isuke Imada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP5508279A priority Critical patent/JPS55147271A/en
Priority to US06/115,548 priority patent/US4284644A/en
Priority to GR61757A priority patent/GR66729B/el
Priority to ZA00802541A priority patent/ZA802541B/en
Priority to DK184680A priority patent/DK153551C/en
Priority to AU57903/80A priority patent/AU534940B2/en
Priority to DE8181104398T priority patent/DE3067491D1/en
Priority to CA000351051A priority patent/CA1150287A/en
Priority to DE8181104399T priority patent/DE3068085D1/en
Priority to EP81104399A priority patent/EP0039091B1/en
Priority to EP80301431A priority patent/EP0018830B1/en
Priority to EP81104398A priority patent/EP0038576B1/en
Priority to DE8080301431T priority patent/DE3063660D1/en
Priority to AT470181A priority patent/AT380018B/en
Priority to NO801290A priority patent/NO155053C/en
Priority to AT0233880A priority patent/AT383122B/en
Priority to ES491150A priority patent/ES8104996A1/en
Priority to SU802917050A priority patent/SU1022658A3/en
Publication of JPS55147271A publication Critical patent/JPS55147271A/en
Priority to ES497669A priority patent/ES497669A0/en
Priority to US06/257,316 priority patent/US4342779A/en
Priority to ES502178A priority patent/ES502178A0/en
Priority to ES502179A priority patent/ES502179A0/en
Priority to NO811787A priority patent/NO154838C/en
Priority to NO811788A priority patent/NO154839C/en
Priority to DK344881A priority patent/DK344881A/en
Priority to DK344781A priority patent/DK344781A/en
Priority to CA000394405A priority patent/CA1138469A/en
Priority to CA000394406A priority patent/CA1140562A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

NEW MATERIAL:A spiro compound I (R is H or lower alkyl; R' is lower alkyl; R and R' may together with the adjacent N atom form a cyclic amino group).
EXAMPLE: 7-Methylaminospiro[benzo(b)furan-2(3H),1'-cyclopropan]-3-one.
USE: It has gastric juice secretion suppressing, antiphlogistic, analgesic actions, etc. for mammals, and is useful as an antiulcer, antiphlogistic, analgesic agents, etc. effective to diseases, e.g. peptic ulcer, duodenal ulcer, acute and chronic gastritis, lumbago, arthritis, etc. Applicable by oral administration.
PROCESS: For example, the compound I is prepared by catalytically reducing the compound II at 10W100°C in the presence of a carbonyl compound (e.g. formaldehyde, acetaldehyde, etc.) and a catalyst (e.g. platinum oxide), or by alkylating the compound III.
COPYRIGHT: (C)1980,JPO&Japio
JP5508279A 1977-01-12 1979-05-04 Spiro compound and its preparation Pending JPS55147271A (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
JP5508279A JPS55147271A (en) 1979-05-04 1979-05-04 Spiro compound and its preparation
US06/115,548 US4284644A (en) 1977-01-12 1980-01-25 Spirobenzofuranone compounds
GR61757A GR66729B (en) 1979-05-04 1980-04-23
ZA00802541A ZA802541B (en) 1979-05-04 1980-04-28 Spirobenzofuranones, their production and use
DK184680A DK153551C (en) 1979-05-04 1980-04-29 METHOD OF ANALOGY FOR THE PREPARATION OF SPIROBENZOFURANONE COMPOUNDS OR SALTS THEREOF WITH INORGANIC OR ORGANIC ACIDS OR ALKALIMETALS
AU57903/80A AU534940B2 (en) 1979-05-04 1980-04-30 Spirobenzofuranones
DE8181104398T DE3067491D1 (en) 1979-05-04 1980-05-01 7-ACETYL SPIROBENZOFURANONE COMPOUND
CA000351051A CA1150287A (en) 1979-05-04 1980-05-01 Spirobenzofuranones, their production and use
DE8181104399T DE3068085D1 (en) 1979-05-04 1980-05-01 SPIROBENZOFURANONE COMPOUNDS
EP81104399A EP0039091B1 (en) 1979-05-04 1980-05-01 Spirobenzofuranone compounds
EP80301431A EP0018830B1 (en) 1979-05-04 1980-05-01 Spirobenzofuranones, their production and pharmaceutical compositions containing them
EP81104398A EP0038576B1 (en) 1979-05-04 1980-05-01 7-acetylspirobenzofuranone compound
DE8080301431T DE3063660D1 (en) 1979-05-04 1980-05-01 Spirobenzofuranones, their production and pharmaceutical compositions containing them
AT470181A AT380018B (en) 1979-05-04 1980-05-02 METHOD FOR PRODUCING THE NEW 7-ACETYL SPIRO (BENZO (B) FURAN-2 (3H), 1'-CYCLOPROPAN) -3-ONS
AT0233880A AT383122B (en) 1979-05-04 1980-05-02 METHOD FOR PRODUCING NEW SPIROBENZOFURANONE COMPOUNDS
NO801290A NO155053C (en) 1979-05-04 1980-05-02 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE SPIROBENZOFURANON COMPOUNDS.
ES491150A ES8104996A1 (en) 1979-05-04 1980-05-03 Spirobenzofuranones, their production and pharmaceutical compositions containing them.
SU802917050A SU1022658A3 (en) 1979-05-04 1980-05-05 Method of producing spirobenzofurans
ES497669A ES497669A0 (en) 1979-05-04 1980-12-12 A PROCEDURE FOR PRODUCING SPIROBENZOFU-RANONA COMPOUNDS
US06/257,316 US4342779A (en) 1977-12-27 1981-04-17 7-Acetylspirobenzofuranone compound
ES502178A ES502178A0 (en) 1979-05-04 1981-05-13 A PROCEDURE FOR OBTAINING A SPIROBENZOFU-RANONA COMPOUND
ES502179A ES502179A0 (en) 1979-05-04 1981-05-13 A PROCEDURE FOR OBTAINING 7-ACETYLESPIRE (BENZO (B) FURAN-2 (3H) -1'-CYCLOPROPANE) -3-ONA
NO811787A NO154838C (en) 1979-05-04 1981-05-26 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE SPIROBENZOFURANON COMPOUNDS.
NO811788A NO154839C (en) 1979-05-04 1981-05-26 ANALOGUE PROCEDURE FOR PREPARING A 7-ACETYL PIROBENZOFURANONE COMPOUND WITH THERAPEUTIC ACTIVITY.
DK344881A DK344881A (en) 1979-05-04 1981-08-03 METHOD FOR PREPARING 7-ACETYLPIRO (BENZO (B) FURAN-2 (3H), 1! -CYCLOPROPAN) -3-ON.
DK344781A DK344781A (en) 1979-05-04 1981-08-03 PROCEDURE FOR PREPARING SPIROBENZOFURANONE COMPOUNDS
CA000394405A CA1138469A (en) 1979-05-04 1982-01-18 Spirobenzofuranones, their production and use
CA000394406A CA1140562A (en) 1979-05-04 1982-01-18 Spirobenzofuranones, their production and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5508279A JPS55147271A (en) 1979-05-04 1979-05-04 Spiro compound and its preparation

Publications (1)

Publication Number Publication Date
JPS55147271A true JPS55147271A (en) 1980-11-17

Family

ID=12988780

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5508279A Pending JPS55147271A (en) 1977-01-12 1979-05-04 Spiro compound and its preparation

Country Status (2)

Country Link
JP (1) JPS55147271A (en)
ZA (1) ZA802541B (en)

Also Published As

Publication number Publication date
ZA802541B (en) 1981-05-27

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