JPS55139351A - Preparation of optically active thiol by radical reaction of vinyl ester of optically active alcohol with thioacetic acid - Google Patents
Preparation of optically active thiol by radical reaction of vinyl ester of optically active alcohol with thioacetic acidInfo
- Publication number
- JPS55139351A JPS55139351A JP4567779A JP4567779A JPS55139351A JP S55139351 A JPS55139351 A JP S55139351A JP 4567779 A JP4567779 A JP 4567779A JP 4567779 A JP4567779 A JP 4567779A JP S55139351 A JPS55139351 A JP S55139351A
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- vinyl ester
- thioacetic acid
- thiol
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain an optically active thiol, by the reduction of a thioester derivative given by the radical addition reaction of the vinyl ester of an optically active alcohol with thioacetic acid.
CONSTITUTION: The optically active vinyl ester of formula I (R1, R2 and R3 are H, alkyl, phenyl, etc.; R4 is an atomic group having an optically active center), is brought into radical addition reaction with thioacetic acid, in the presence of azobisisobutyronitrile, etc., to give a thioester derivative of formula II. The resulting thioester derivative is reduced with lithium aluminum hydride, to prepare the optically active thiol which is the object compound of formula III. Combinations of R1, R2 and R3 enable the introduction of the optically active center into the Cα or Cβ atom arbitrarily.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4567779A JPS55139351A (en) | 1979-04-14 | 1979-04-14 | Preparation of optically active thiol by radical reaction of vinyl ester of optically active alcohol with thioacetic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4567779A JPS55139351A (en) | 1979-04-14 | 1979-04-14 | Preparation of optically active thiol by radical reaction of vinyl ester of optically active alcohol with thioacetic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS55139351A true JPS55139351A (en) | 1980-10-31 |
Family
ID=12726013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4567779A Pending JPS55139351A (en) | 1979-04-14 | 1979-04-14 | Preparation of optically active thiol by radical reaction of vinyl ester of optically active alcohol with thioacetic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55139351A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011074016A (en) * | 2009-09-30 | 2011-04-14 | Toyobo Co Ltd | Method of manufacturing 3-mercapto-1-propanol |
-
1979
- 1979-04-14 JP JP4567779A patent/JPS55139351A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011074016A (en) * | 2009-09-30 | 2011-04-14 | Toyobo Co Ltd | Method of manufacturing 3-mercapto-1-propanol |
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