JPS55111448A - Novel butenophenone derivative - Google Patents

Novel butenophenone derivative

Info

Publication number
JPS55111448A
JPS55111448A JP1857979A JP1857979A JPS55111448A JP S55111448 A JPS55111448 A JP S55111448A JP 1857979 A JP1857979 A JP 1857979A JP 1857979 A JP1857979 A JP 1857979A JP S55111448 A JPS55111448 A JP S55111448A
Authority
JP
Japan
Prior art keywords
derivative
formula
butenophenone
trans
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1857979A
Other languages
Japanese (ja)
Inventor
Yoshiyuki Kojima
Tsunemasa Irie
Shuichi Harada
Yoshito Kameno
Sumimoto Katsube
Hisao Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP1857979A priority Critical patent/JPS55111448A/en
Publication of JPS55111448A publication Critical patent/JPS55111448A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NEW MATERIAL:A trans-butenophenone derivative of formula I (Ar is phenyl, furyl groups, etc.; R1 is 5W8C alkyl, lower alkenyl group, etc.; R2 is lower alkyl, benzyl group, etc.; NR1R2 is morpholino, N-methylpiperazino group, etc.).
EXAMPLE: N-( 4-Phenyl-4-oxo-2-transbutenyl )-N-methyl-cyclohexylaminehydrochloride.
USE: Preventives and remedies for cerebro-cardiovascular thrombosis, having blood platelet antiagglutinating actions.
PROCESS: An aldehyde of formula V is reacted with a metallic compound of a propargylamine derivative of formula VI (M' is magnesium halide, etc.) to form an alkynolamine derivative of formula III, which is reduced with LiAlH4 to give a trans-alkenolamine derivative of formula II. The resulting compound is oxidized with MnO2, etc., to afford the trans-butenophenone derivative of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP1857979A 1979-02-19 1979-02-19 Novel butenophenone derivative Pending JPS55111448A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1857979A JPS55111448A (en) 1979-02-19 1979-02-19 Novel butenophenone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1857979A JPS55111448A (en) 1979-02-19 1979-02-19 Novel butenophenone derivative

Publications (1)

Publication Number Publication Date
JPS55111448A true JPS55111448A (en) 1980-08-28

Family

ID=11975530

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1857979A Pending JPS55111448A (en) 1979-02-19 1979-02-19 Novel butenophenone derivative

Country Status (1)

Country Link
JP (1) JPS55111448A (en)

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