JPS55104296A - Antibiotic substance c-19393s2 and its preparation - Google Patents

Antibiotic substance c-19393s2 and its preparation

Info

Publication number
JPS55104296A
JPS55104296A JP1156079A JP1156079A JPS55104296A JP S55104296 A JPS55104296 A JP S55104296A JP 1156079 A JP1156079 A JP 1156079A JP 1156079 A JP1156079 A JP 1156079A JP S55104296 A JPS55104296 A JP S55104296A
Authority
JP
Japan
Prior art keywords
gram
positive
supernatant liquid
cultivation product
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1156079A
Other languages
Japanese (ja)
Other versions
JPS6125356B2 (en
Inventor
Satoru Imada
Setsuo Harada
Mitsuko Asai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP1156079A priority Critical patent/JPS55104296A/en
Priority to AU54518/80A priority patent/AU534530B2/en
Priority to DK12580A priority patent/DK12580A/en
Priority to GR60953A priority patent/GR73818B/el
Priority to US06/113,132 priority patent/US4518529A/en
Priority to PT70710A priority patent/PT70710A/en
Priority to CH67680A priority patent/CH646432A5/en
Priority to ZA00800496A priority patent/ZA80496B/en
Priority to HU80180A priority patent/HU181721B/en
Priority to NL8000628A priority patent/NL8000628A/en
Priority to FR8002162A priority patent/FR2447922A1/en
Priority to ES488836A priority patent/ES488836A0/en
Priority to DE19803003624 priority patent/DE3003624A1/en
Priority to SE8000842A priority patent/SE8000842L/en
Priority to BE0/199232A priority patent/BE881509A/en
Priority to PH23567A priority patent/PH14316A/en
Priority to IT19645/80A priority patent/IT1130246B/en
Priority to SU802878699A priority patent/SU1075984A3/en
Priority to GB8003402A priority patent/GB2042532B/en
Publication of JPS55104296A publication Critical patent/JPS55104296A/en
Publication of JPS6125356B2 publication Critical patent/JPS6125356B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Abstract

NEW MATERIAL:Antibiotic substance C-19393S2. Appearance, white powder; specific rotatory power, [α]D22=-152±15° (c=0.5, water), molecular formula (estimation), C14H16N2Na2O9S2; solubility, insoluble in chloroform, ethyl acetate, etc., slightly soluble in ethanol, pyridine, etc., soluble in methanol, acetic acid, etc.; color reactions, positive to Ehrlich reaction, etc., negative to ninhydrin reaction, etc.
USE: A remedy for infectious diseases, and an antiseptic agent. Effectice to gram- positive and gram-negative bacteria. Exhibits synergistic effect with penicillin or cephalosporin antibiotics. An intermediate of medicine. Stable at neutral pH range.
PROCESS: Streptomyces sp.C-19393 (FERM-P No.4774) are cultured in a medium at 15W32°C and about pH 4W8, for about 8W16hr. The cultivation product is separated into the supernatant liquid and the bacterial cells pref. by centrifugal separation. The objective substance can be obtained from the supernatant liquid or the cultivation product.
COPYRIGHT: (C)1980,JPO&Japio
JP1156079A 1979-02-02 1979-02-02 Antibiotic substance c-19393s2 and its preparation Granted JPS55104296A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP1156079A JPS55104296A (en) 1979-02-02 1979-02-02 Antibiotic substance c-19393s2 and its preparation
AU54518/80A AU534530B2 (en) 1979-02-02 1980-01-10 5-aza-(3.2.0)-heptane derivatives
DK12580A DK12580A (en) 1979-02-02 1980-01-11 ANTIBIOTICS C-19393S2 AND H2
GR60953A GR73818B (en) 1979-02-02 1980-01-14
US06/113,132 US4518529A (en) 1979-02-02 1980-01-17 Antibiotics C-19393S2
PT70710A PT70710A (en) 1979-02-02 1980-01-18 Antibiotics c-19393 s2 and h2
CH67680A CH646432A5 (en) 1979-02-02 1980-01-28 BETA LACTAM ANTIBIOTICS.
ZA00800496A ZA80496B (en) 1979-02-02 1980-01-28 Antibiotics c-19393s2 and h2
HU80180A HU181721B (en) 1979-02-02 1980-01-28 Process for preparing antibiotics c-19393sdown 2 and c-1939hdown 2
NL8000628A NL8000628A (en) 1979-02-02 1980-01-31 ANTIBIOTICS C-19393S2 AND H2.
FR8002162A FR2447922A1 (en) 1979-02-02 1980-01-31 ANTIBIOTICS C-19393 S2 AND C-19393 H2 AND THEIR SALTS, THEIR PREPARATION METHOD FROM MICROORGANISMS OF THE STREPTOMYCE GENUS AND THEIR USE IN MEDICINAL PREPARATIONS
ES488836A ES488836A0 (en) 1979-02-02 1980-01-31 METHOD OF PRODUCING ANTIBIOTICS OF THE TYPE BASED ON STREPTOMYCES.
DE19803003624 DE3003624A1 (en) 1979-02-02 1980-02-01 ANTIBIOTICA C-19393 S LOW 2 AND H LOW 2
SE8000842A SE8000842L (en) 1979-02-02 1980-02-01 NEW ANTIBIOTICS
BE0/199232A BE881509A (en) 1979-02-02 1980-02-01 ANTIBIOTICS C-19393 S2 AND C-19393 H2 AND THEIR SALTS, THEIR PREPARATION PROCESS FROM MICROORGANISMS AND THEIR USE
PH23567A PH14316A (en) 1979-02-02 1980-02-01 Antibiotics c-19393 s2 and h2 and method of preparation thereof
IT19645/80A IT1130246B (en) 1979-02-02 1980-02-01 ANTIBIOTIC AND MICROBIOLOGICAL PROCEDURE TO PRODUCE IT
SU802878699A SU1075984A3 (en) 1979-02-02 1980-02-01 Process for preparing antibiotic c-19393 s2 and/or c-19393 h2
GB8003402A GB2042532B (en) 1979-02-02 1980-02-01 Antibiotics c-19393 s2 and 'i

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1156079A JPS55104296A (en) 1979-02-02 1979-02-02 Antibiotic substance c-19393s2 and its preparation

Publications (2)

Publication Number Publication Date
JPS55104296A true JPS55104296A (en) 1980-08-09
JPS6125356B2 JPS6125356B2 (en) 1986-06-14

Family

ID=11781312

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1156079A Granted JPS55104296A (en) 1979-02-02 1979-02-02 Antibiotic substance c-19393s2 and its preparation

Country Status (3)

Country Link
JP (1) JPS55104296A (en)
BE (1) BE881509A (en)
ZA (1) ZA80496B (en)

Also Published As

Publication number Publication date
JPS6125356B2 (en) 1986-06-14
ZA80496B (en) 1981-02-25
BE881509A (en) 1980-08-01

Similar Documents

Publication Publication Date Title
WO1999025719A1 (en) Novel physiologically active substance sulphostin, process for producing the same, and use thereof
JPS54163501A (en) Antibiotic substance g-6302
JPS55104296A (en) Antibiotic substance c-19393s2 and its preparation
JPS568688A (en) Antitumor substance 1166a and its preparation
IE37892B1 (en) Antibiotic a-2315 and process for preparation thereof
JPS568687A (en) Preparation of creatinase
JPS5788195A (en) Antibiotic, oxanosine, and its preparation
JPS54154792A (en) Novel antibiotic a-11079-b1b and its preparation
JPS57154195A (en) Novel antibiotic lysopeptin a and b and their preparations
KR820000513B1 (en) Process for preparation of antibiotic having lactamase inhibitory activity
JPS5699495A (en) Novel antibiotic substance, its preparation, and pharmaceutical containing said substance as effective component
JPS55102597A (en) Novel antibiotic substance, bactropone, and its preparation
JPS57109798A (en) Antibiotic substance and its preparation
JPS56142250A (en) Antibiotic, mycoplanecin c, and its preparation
JPS55124794A (en) Cytophagin and its preparation
SU440847A1 (en) METHOD OF OBTAINING ANTIBIOTICS
JPS54117478A (en) New antibiotics fortimicin kg1, kg2, and kg3, and their preparation
JPS5785397A (en) Novel antibiotic sf-2140 substance and its preparation
JPS57114547A (en) Anthracycline antibiotic substance and its preparation
JPS5515409A (en) Novel substance kx-206 and its preparation
JPS5643295A (en) Istamycin ao and/or istamycin bo, and their preparation
JPS5569594A (en) Novel substance d-53 and its preparation
JPS5579396A (en) Novel antibiotic, sf-2012-l substance, and its preparation
IE42705L (en) Cephalosporin compounds.
JPS5791993A (en) Novel antibiotic substance, its preparation and microorganism capable of producing the same