JPS55100377A - Intermediate for prostaglandim analog and its preparation - Google Patents

Intermediate for prostaglandim analog and its preparation

Info

Publication number
JPS55100377A
JPS55100377A JP655579A JP655579A JPS55100377A JP S55100377 A JPS55100377 A JP S55100377A JP 655579 A JP655579 A JP 655579A JP 655579 A JP655579 A JP 655579A JP S55100377 A JPS55100377 A JP S55100377A
Authority
JP
Japan
Prior art keywords
formula
tetrahydropyran
analog
compound
prostaglandim
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP655579A
Other languages
Japanese (ja)
Inventor
Hirohisa Wakatsuka
Masanori Kawamura
Tadanori Okada
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP655579A priority Critical patent/JPS55100377A/en
Priority to HU80142A priority patent/HU183068B/en
Priority to GB8002207A priority patent/GB2045745B/en
Priority to SE8000545A priority patent/SE452157B/en
Priority to IT19399/80A priority patent/IT1149877B/en
Priority to CA000344233A priority patent/CA1154441A/en
Priority to NL8000428A priority patent/NL8000428A/en
Priority to DK027780A priority patent/DK165111C/en
Priority to FR8001501A priority patent/FR2447374A1/en
Priority to CH57680A priority patent/CH644360A5/en
Publication of JPS55100377A publication Critical patent/JPS55100377A/en
Pending legal-status Critical Current

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  • Pyrane Compounds (AREA)

Abstract

NEW MATERIAL:A prostaglandin analog of formula I (R1 is H, tetrahydropyran- 2-yl, etc.; R2 is H, trityl, etc.; R3 is formyl, etc.; R4 is benzyl, etc.; THP is tetrahydropyran-2-yl, etc.; X is ethylene, etc.; n is 0 or an integer 1W5; R1 and R2 are not H when R3 is formyl).
EXAMPLE: (EZ)-2α-(5-Hydroxy-2-pentenyl)-3β-(1-methoxy-1-methyl)-ethoxymethyl-4α-(tetrahydropyran-2-yloxy)cyclopentan-1-α-ol.
USE: An intermediate for prostaglandin useful as medicines or drugs for animals, or preparing analogs thereof.
PROCESS: A compound of formula I is subjected to the witting reaction with a ylide of a phosphonium compound of formula III (X is halogen; R5 is H, etc.) in a solvent, e.g. THF, to give the objective compound of formula IV.
COPYRIGHT: (C)1980,JPO&Japio
JP655579A 1979-01-25 1979-01-25 Intermediate for prostaglandim analog and its preparation Pending JPS55100377A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP655579A JPS55100377A (en) 1979-01-25 1979-01-25 Intermediate for prostaglandim analog and its preparation
HU80142A HU183068B (en) 1979-01-25 1980-01-23 Process for preparing prostaglandin e down 1 analogues
GB8002207A GB2045745B (en) 1979-01-25 1980-01-23 Intermediates for prostaglandin analogues
SE8000545A SE452157B (en) 1979-01-25 1980-01-23 INTERMEDIATES FOR THE MANUFACTURING OF TRANS- DELTA? 722-PROSTAGLANDIN-E? 711-ANALOGS AND PROCEDURES FOR PRODUCING THESE
IT19399/80A IT1149877B (en) 1979-01-25 1980-01-23 INTERMEDIATE PRODUCTS FOR ANALOGS OF PROSTAGLANDINA
CA000344233A CA1154441A (en) 1979-01-25 1980-01-23 Intermediates for prostaglandin analogues
NL8000428A NL8000428A (en) 1979-01-25 1980-01-23 INTERMEDIATES FOR THE PREPARATION OF PROSTAGLANDINE ANALOGS, METHODS FOR PREPARING THEM AND THEIR USE IN THE PREPARATION OF PROSTAGLANDINE ANALOGS.
DK027780A DK165111C (en) 1979-01-25 1980-01-23 CYCLOPENTAND DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
FR8001501A FR2447374A1 (en) 1979-01-25 1980-01-24 INTERMEDIATES FOR THE PREPARATION OF 2TRANS-PROSTAGLANDIN E1 ANALOGS
CH57680A CH644360A5 (en) 1979-01-25 1980-01-24 INTERMEDIATES FOR THE PREPARATION OF TRANS-PROSTAGLANDIN ANALOGS HAVING A DOUBLE LINK BETWEEN CARBON ATOMS 13 AND 14 AND 2 AND 3.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP655579A JPS55100377A (en) 1979-01-25 1979-01-25 Intermediate for prostaglandim analog and its preparation

Publications (1)

Publication Number Publication Date
JPS55100377A true JPS55100377A (en) 1980-07-31

Family

ID=11641571

Family Applications (1)

Application Number Title Priority Date Filing Date
JP655579A Pending JPS55100377A (en) 1979-01-25 1979-01-25 Intermediate for prostaglandim analog and its preparation

Country Status (1)

Country Link
JP (1) JPS55100377A (en)

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