JPS5497691A - New mitomycin derivative - Google Patents

New mitomycin derivative

Info

Publication number
JPS5497691A
JPS5497691A JP368478A JP368478A JPS5497691A JP S5497691 A JPS5497691 A JP S5497691A JP 368478 A JP368478 A JP 368478A JP 368478 A JP368478 A JP 368478A JP S5497691 A JPS5497691 A JP S5497691A
Authority
JP
Japan
Prior art keywords
polysaccharide
mitomycin
spacer
reacted
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP368478A
Other languages
Japanese (ja)
Other versions
JPS6216930B2 (en
Inventor
Shozo Muranishi
Hitoshi Sezaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP368478A priority Critical patent/JPS5497691A/en
Publication of JPS5497691A publication Critical patent/JPS5497691A/en
Publication of JPS6216930B2 publication Critical patent/JPS6216930B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To prepare a new mitomycin derivative having enhanced lymph migration characteristics and an increased retention time in blood and unsusceptible to enzymatic degradation, by bonding mitomycin to polysaccharide through a spacer.
CONSTITUTION: (1) An aliphatic acid having a terminal amino group, e.g., ε- amino-n-caproic acid, etc., as a spacer is added to an aqueous solution (pH=9) of an activated polysaccharide, e.g. dextran, etc., and reacted at room temperature for preferably 12W48 hr; and dialyzed, etc. to give a polysaccharide intermediate bonded to the spacer. (2) The intermediate is reacted with mitomycin and a binding agent, e.g. 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, etc., at pH 5W6 and at room temperature. The reaction mixture is ultrafiltrated, washed, concentrated and recrystallized with acetone to give the desired mitomycin derivative. The activation of the polysaccharide is accomplished by adding a halogenated cyanide, e.g. chlorocyanide, etc., to an aqueous solution of the polysaccharide and adjusting pH to 10.7 with sodium hydroxide.
COPYRIGHT: (C)1979,JPO&Japio
JP368478A 1978-01-19 1978-01-19 New mitomycin derivative Granted JPS5497691A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP368478A JPS5497691A (en) 1978-01-19 1978-01-19 New mitomycin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP368478A JPS5497691A (en) 1978-01-19 1978-01-19 New mitomycin derivative

Publications (2)

Publication Number Publication Date
JPS5497691A true JPS5497691A (en) 1979-08-01
JPS6216930B2 JPS6216930B2 (en) 1987-04-15

Family

ID=11564219

Family Applications (1)

Application Number Title Priority Date Filing Date
JP368478A Granted JPS5497691A (en) 1978-01-19 1978-01-19 New mitomycin derivative

Country Status (1)

Country Link
JP (1) JPS5497691A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6067502A (en) * 1983-09-24 1985-04-17 Kyowa Hakko Kogyo Co Ltd Novel mitomycin derivative
JPS63307825A (en) * 1987-06-08 1988-12-15 Nippon Beet Sugar Mfg Co Ltd Antitumor agent and production thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6067502A (en) * 1983-09-24 1985-04-17 Kyowa Hakko Kogyo Co Ltd Novel mitomycin derivative
JPS63307825A (en) * 1987-06-08 1988-12-15 Nippon Beet Sugar Mfg Co Ltd Antitumor agent and production thereof

Also Published As

Publication number Publication date
JPS6216930B2 (en) 1987-04-15

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