JPS5492972A - Manufacture of nucleoside - Google Patents

Manufacture of nucleoside

Info

Publication number
JPS5492972A
JPS5492972A JP15429578A JP15429578A JPS5492972A JP S5492972 A JPS5492972 A JP S5492972A JP 15429578 A JP15429578 A JP 15429578A JP 15429578 A JP15429578 A JP 15429578A JP S5492972 A JPS5492972 A JP S5492972A
Authority
JP
Japan
Prior art keywords
nucleoside
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15429578A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6230997B2 (show.php
Inventor
Fuoruburiyutsugen Herumuuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of JPS5492972A publication Critical patent/JPS5492972A/ja
Publication of JPS6230997B2 publication Critical patent/JPS6230997B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP15429578A 1977-12-20 1978-12-15 Manufacture of nucleoside Granted JPS5492972A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772757365 DE2757365A1 (de) 1977-12-20 1977-12-20 Neues verfahren zur herstellung von nucleosiden

Publications (2)

Publication Number Publication Date
JPS5492972A true JPS5492972A (en) 1979-07-23
JPS6230997B2 JPS6230997B2 (show.php) 1987-07-06

Family

ID=6026942

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15429578A Granted JPS5492972A (en) 1977-12-20 1978-12-15 Manufacture of nucleoside

Country Status (5)

Country Link
US (1) US4209613A (show.php)
EP (1) EP0003229B1 (show.php)
JP (1) JPS5492972A (show.php)
CA (1) CA1107277A (show.php)
DE (2) DE2757365A1 (show.php)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007527396A (ja) * 2003-06-30 2007-09-27 イデニクス（ケイマン）リミテツド β−Ｌ−２’−デオキシヌクレオシドの合成

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
CA2091732C (en) * 1992-07-08 1998-07-21 Anica Markovac A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
FR2750699B1 (fr) * 1996-07-05 1998-12-04 Univ Picardie Procede de synthese regiospecifique de nouveaux derives 3-hydroxypydirin-4(1h)-ones a partir d'aminomonosaccharides ou d'aminoitols. produits obtenus par ce procede et leurs applications
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
IL153020A0 (en) 2000-05-26 2003-06-24 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
KR20050035194A (ko) 2002-06-28 2005-04-15 이데닉스 (케이만) 리미티드 플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
ES2624353T3 (es) * 2002-11-15 2017-07-13 Idenix Pharmaceuticals Llc 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae
AU2003300901A1 (en) * 2002-12-12 2004-06-30 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
CN1812995A (zh) * 2003-04-28 2006-08-02 艾登尼科斯（开曼）有限公司 工业化规模的核苷合成
CN100475831C (zh) * 2003-06-30 2009-04-08 诺瓦蒂斯有限公司 β-L-2＇-脱氧核苷的合成
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
EP1976382B1 (en) * 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
PT2695609T (pt) 2008-05-15 2020-03-02 Celgene Corp Formulações orais de análogos da citidina e métodos de utilização dos mesmos
WO2010014883A2 (en) 2008-08-01 2010-02-04 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs
KR101660549B1 (ko) * 2008-08-08 2016-09-27 시노팜 타이완 리미티드 ５―아자시토신 뉴클레오시드 및 이의 유도체의 제조 방법
US8586729B2 (en) * 2008-10-03 2013-11-19 Scinopharm Taiwan Ltd. Synthesis of decitabine
MX2013010945A (es) 2011-03-31 2014-03-12 Celgene Internat Sarl Sintesis de 5 - azacitidina.
LT2833905T (lt) 2012-04-04 2018-07-10 Halozyme, Inc. Derinių terapija su hialuronidaze ir į naviką nukreiptu taksanu
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US3352849A (en) * 1965-10-24 1967-11-14 Merck & Co Inc 6-aza-2'-deoxyuridines
US3531464A (en) * 1966-10-21 1970-09-29 Us Health Education & Welfare Alternative synthesis of 2'-deoxy-5-(trifluoromethyl)-uridine and the alphaanomer thereof
DE1795357A1 (de) * 1968-09-18 1972-01-05 Schering Ag 2-Thio-pyrimidin-nucleoside
CH541566A (de) * 1969-04-11 1973-09-15 Schering Ag Verfahren zur Herstellung von Nucleosiden
DE2012888C3 (de) * 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden
DE2508312A1 (de) * 1975-02-24 1976-09-02 Schering Ag Neues verfahren zur herstellung von nucleosiden

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007527396A (ja) * 2003-06-30 2007-09-27 イデニクス（ケイマン）リミテツド β−Ｌ−２’−デオキシヌクレオシドの合成

Also Published As

Publication number Publication date
US4209613A (en) 1980-06-24
EP0003229A1 (de) 1979-08-08
EP0003229B1 (de) 1981-12-02
CA1107277A (en) 1981-08-18
DE2861427D1 (en) 1982-01-28
JPS6230997B2 (show.php) 1987-07-06
DE2757365A1 (de) 1979-06-21

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