JPS5459295A - Antibiotic ps-6, its derivative and their preparation - Google Patents

Antibiotic ps-6, its derivative and their preparation

Info

Publication number
JPS5459295A
JPS5459295A JP12185777A JP12185777A JPS5459295A JP S5459295 A JPS5459295 A JP S5459295A JP 12185777 A JP12185777 A JP 12185777A JP 12185777 A JP12185777 A JP 12185777A JP S5459295 A JPS5459295 A JP S5459295A
Authority
JP
Japan
Prior art keywords
formula
antibiotics
preparation
produce
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12185777A
Other languages
Japanese (ja)
Other versions
JPS6215557B2 (en
Inventor
Kazuhiko Okamura
Shoji Hirata
Yasushi Okumura
Yasuo Fukagawa
Yasutaka Shimauchi
Tomoyuki Ishikura
Kageaki Kono
Riin Jiyosefu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanraku Inc
Sanraku Ocean Co Ltd
Original Assignee
Sanraku Inc
Sanraku Ocean Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanraku Inc, Sanraku Ocean Co Ltd filed Critical Sanraku Inc
Priority to JP12185777A priority Critical patent/JPS5459295A/en
Priority to DE7878100993T priority patent/DE2861413D1/en
Priority to EP78100993A priority patent/EP0001567B1/en
Priority to YU235178A priority patent/YU235178A/en
Priority to US05/949,854 priority patent/US4368203A/en
Priority to DK454378A priority patent/DK145382C/en
Priority to SU782673547A priority patent/SU1039446A3/en
Priority to HU78SA3138A priority patent/HU179788B/en
Priority to CA313,287A priority patent/CA1113872A/en
Priority to IT28782/78A priority patent/IT1099738B/en
Publication of JPS5459295A publication Critical patent/JPS5459295A/en
Priority to YU2151/82A priority patent/YU42049B/en
Publication of JPS6215557B2 publication Critical patent/JPS6215557B2/ja
Granted legal-status Critical Current

Links

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:compounds of the formula (R is H, lower alkyl, triphenylmethyl). EXAMPLE:PS - 6 of the formula where R is H. USE:Antibiotics: effective on gram-positive and negative bacteria, especially having strong antibiotic activity against bacteria resisting conventional beta-lactam antibiotics. PREPARATION:In an example, a novel mold of streptomyces SP, A 271 is aerobically cultivated in the medium containing L- and/or D-valine, L- and D-leucine at 4-9pH and 20-40 deg.C for 0-100hr to produce PS-6 of the formula where R is H and it is isolated. The resulting PS-6 or its salt is reacted with an ester-forming compound of RY (Y is removable group) or a lower diazoalkane to produce antibiotics other than R is H.
JP12185777A 1977-10-13 1977-10-13 Antibiotic ps-6, its derivative and their preparation Granted JPS5459295A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP12185777A JPS5459295A (en) 1977-10-13 1977-10-13 Antibiotic ps-6, its derivative and their preparation
DE7878100993T DE2861413D1 (en) 1977-10-13 1978-09-26 Thienamycin related antibiotics ps-6 and ps-7, process for their production and compositions containing them
EP78100993A EP0001567B1 (en) 1977-10-13 1978-09-26 Thienamycin related antibiotics ps-6 and ps-7, process for their production and compositions containing them
YU235178A YU235178A (en) 1977-10-13 1978-10-06 Process for producing new antibiotics of a betta-lactamaseinhibiting activity
US05/949,854 US4368203A (en) 1977-10-13 1978-10-10 Antibiotics and derivatives thereof having β-lactamase inhibitory activity and production thereof
DK454378A DK145382C (en) 1977-10-13 1978-10-12 METHOD OF PREPARING BETA-LACTAMANTIBIOTICS CALLED PS-6 AND PS-7 OR SALTS OR ESTERS THEREOF
SU782673547A SU1039446A3 (en) 1977-10-13 1978-10-12 Process for preparing antibiotic complex
HU78SA3138A HU179788B (en) 1977-10-13 1978-10-12 Process for preparing new carbopenem derivatives
CA313,287A CA1113872A (en) 1977-10-13 1978-10-12 ANTIBIOTICS AND DERIVATIVES THEREOF HAVING .beta.-LACTAMASE INHIBITORY ACTIVITY AND PRODUCTION THEREOF
IT28782/78A IT1099738B (en) 1977-10-13 1978-10-13 ANTIBIOTICS, THEIR PREPARATION AND THEIR USE AS ANTI-MICROBIAL PRODUCTS
YU2151/82A YU42049B (en) 1977-10-13 1982-09-27 Process for producing derivatives of new antibiotics of a beta lactamase inhibiting activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12185777A JPS5459295A (en) 1977-10-13 1977-10-13 Antibiotic ps-6, its derivative and their preparation

Publications (2)

Publication Number Publication Date
JPS5459295A true JPS5459295A (en) 1979-05-12
JPS6215557B2 JPS6215557B2 (en) 1987-04-08

Family

ID=14821641

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12185777A Granted JPS5459295A (en) 1977-10-13 1977-10-13 Antibiotic ps-6, its derivative and their preparation

Country Status (1)

Country Link
JP (1) JPS5459295A (en)

Also Published As

Publication number Publication date
JPS6215557B2 (en) 1987-04-08

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