JPS54138192A - Preparation of androstane compound - Google Patents

Preparation of androstane compound

Info

Publication number
JPS54138192A
JPS54138192A JP4566678A JP4566678A JPS54138192A JP S54138192 A JPS54138192 A JP S54138192A JP 4566678 A JP4566678 A JP 4566678A JP 4566678 A JP4566678 A JP 4566678A JP S54138192 A JPS54138192 A JP S54138192A
Authority
JP
Japan
Prior art keywords
brevibacterium
androstane
sterols
medium
culturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4566678A
Other languages
Japanese (ja)
Inventor
Yukio Imada
Yutaka Teranishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP4566678A priority Critical patent/JPS54138192A/en
Publication of JPS54138192A publication Critical patent/JPS54138192A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare androstane compounds useful as raw material of medicines, economically and in an industrial scale, by culturing a mutant belonging to Brevibacterium genus in a medium containing sterols as substrates, and separating and purifying from the medium.
CONSTITUTION: Mutant of Brevibacterium having no or deactivated androstane compound-decomposing enzyme, e.g. Brevibacterium lypolytica MCI-0805 (FERM-P No.4474), is cultured in a nutrient medium containing various sterols such as cholesterol, stigmasterol, etc., or the oxidation intermediates of various sterols, such as pregnenolone, progesterone, etc., and pref. ≥ 0.1wt% of glycerides, at about 30°C, and after the culturing, the accumulated androstane compounds such as androst-4-ene-3,17-dione, are separated from the medium, and purified.
COPYRIGHT: (C)1979,JPO&Japio
JP4566678A 1978-04-18 1978-04-18 Preparation of androstane compound Pending JPS54138192A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4566678A JPS54138192A (en) 1978-04-18 1978-04-18 Preparation of androstane compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4566678A JPS54138192A (en) 1978-04-18 1978-04-18 Preparation of androstane compound

Publications (1)

Publication Number Publication Date
JPS54138192A true JPS54138192A (en) 1979-10-26

Family

ID=12725701

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4566678A Pending JPS54138192A (en) 1978-04-18 1978-04-18 Preparation of androstane compound

Country Status (1)

Country Link
JP (1) JPS54138192A (en)

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