JPS54138192A - Preparation of androstane compound - Google Patents
Preparation of androstane compoundInfo
- Publication number
- JPS54138192A JPS54138192A JP4566678A JP4566678A JPS54138192A JP S54138192 A JPS54138192 A JP S54138192A JP 4566678 A JP4566678 A JP 4566678A JP 4566678 A JP4566678 A JP 4566678A JP S54138192 A JPS54138192 A JP S54138192A
- Authority
- JP
- Japan
- Prior art keywords
- brevibacterium
- androstane
- sterols
- medium
- culturing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare androstane compounds useful as raw material of medicines, economically and in an industrial scale, by culturing a mutant belonging to Brevibacterium genus in a medium containing sterols as substrates, and separating and purifying from the medium.
CONSTITUTION: Mutant of Brevibacterium having no or deactivated androstane compound-decomposing enzyme, e.g. Brevibacterium lypolytica MCI-0805 (FERM-P No.4474), is cultured in a nutrient medium containing various sterols such as cholesterol, stigmasterol, etc., or the oxidation intermediates of various sterols, such as pregnenolone, progesterone, etc., and pref. ≥ 0.1wt% of glycerides, at about 30°C, and after the culturing, the accumulated androstane compounds such as androst-4-ene-3,17-dione, are separated from the medium, and purified.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4566678A JPS54138192A (en) | 1978-04-18 | 1978-04-18 | Preparation of androstane compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4566678A JPS54138192A (en) | 1978-04-18 | 1978-04-18 | Preparation of androstane compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54138192A true JPS54138192A (en) | 1979-10-26 |
Family
ID=12725701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4566678A Pending JPS54138192A (en) | 1978-04-18 | 1978-04-18 | Preparation of androstane compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54138192A (en) |
-
1978
- 1978-04-18 JP JP4566678A patent/JPS54138192A/en active Pending
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