JPS54132534A - Production of alpha-phenylethylamine - Google Patents
Production of alpha-phenylethylamineInfo
- Publication number
- JPS54132534A JPS54132534A JP4040378A JP4040378A JPS54132534A JP S54132534 A JPS54132534 A JP S54132534A JP 4040378 A JP4040378 A JP 4040378A JP 4040378 A JP4040378 A JP 4040378A JP S54132534 A JPS54132534 A JP S54132534A
- Authority
- JP
- Japan
- Prior art keywords
- nickel
- acetophenone
- hydrogen
- ammonia
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: The catalytic reduction of acetophenone is effected, after the reaction mixture is pretreated for a prescribed time, in the presence of ammonia and a nickel catalyst from reduced nickel or nickel formate, thus producing title compound in high selectivity and yield that is used as an auxiliary agent for optical resolution.
CONSTITUTION: The catalytic reduction of acetophenone in the presence of ammonia and a nickel catalyst affords α-phenylethylamine wherein the reaction mixture containing ammonia, acetophenone is previously kept above room temperature, then hydrogen is introduced, and a nickel catalyst of reduced nickel or prepared by thermal decomposition of nickel formate is employed. The pretreatment is effected at a temperature higher than at least 20°C for a prescribed time, then the mixture is heated to the reaction temperature and hydrogen is introduced or after introduction of hydrogen, the temperature is raised.
USE: An auxiliary agent for optical resolution of carboxylic acid with optically asymmetric carbons or synthetic intermediate.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4040378A JPS54132534A (en) | 1978-04-07 | 1978-04-07 | Production of alpha-phenylethylamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4040378A JPS54132534A (en) | 1978-04-07 | 1978-04-07 | Production of alpha-phenylethylamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS54132534A true JPS54132534A (en) | 1979-10-15 |
Family
ID=12579690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4040378A Pending JPS54132534A (en) | 1978-04-07 | 1978-04-07 | Production of alpha-phenylethylamine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS54132534A (en) |
-
1978
- 1978-04-07 JP JP4040378A patent/JPS54132534A/en active Pending
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