JPS54119469A - Production of nanaomycin a - Google Patents

Production of nanaomycin a

Info

Publication number
JPS54119469A
JPS54119469A JP2504278A JP2504278A JPS54119469A JP S54119469 A JPS54119469 A JP S54119469A JP 2504278 A JP2504278 A JP 2504278A JP 2504278 A JP2504278 A JP 2504278A JP S54119469 A JPS54119469 A JP S54119469A
Authority
JP
Japan
Prior art keywords
formula
nanaomycin
novel
antiobiotic
antibiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2504278A
Other languages
Japanese (ja)
Other versions
JPS6016953B2 (en
Inventor
Satoshi Omura
Haruo Tanaka
Shinzo Ishii
Kazuyuki Mineura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kitasato Institute
KH Neochem Co Ltd
Original Assignee
Kitasato Institute
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kitasato Institute, Kyowa Hakko Kogyo Co Ltd filed Critical Kitasato Institute
Priority to JP53025042A priority Critical patent/JPS6016953B2/en
Priority to GB7907887A priority patent/GB2015526B/en
Publication of JPS54119469A publication Critical patent/JPS54119469A/en
Publication of JPS6016953B2 publication Critical patent/JPS6016953B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: The reduction of a novel antiobiotic, Nonomycin e produces an antibiotic, Nanomycin A which has strong activity against gram-positive bacteria and trichophytns, in inductrial scale.
CONSTITUTION: In an example, a reducing compound such as H2S2O3, Na2S2O4, H2S alone or together with monosaccharide is added to an aqueous solution of a novel antibiotics, Nanaomycin E of formula I in an amount of 0.1W1% and they are made weakly acidic or alkaline in pH, then heated for 30 min to 1hr to produce effectively the antibiotics of formula II. The novel antibiotic of formula I is obtained by incubating aerobically a mould producing Nanaomycin E belonging to Streptomyces such as Streptomyces rosa var. notoensis, FERM P-2209, in an enriched medium and extracting the antiobiotic from the medium.
COPYRIGHT: (C)1979,JPO&Japio
JP53025042A 1978-03-07 1978-03-07 Manufacturing method of Nanaomycin A Expired JPS6016953B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP53025042A JPS6016953B2 (en) 1978-03-07 1978-03-07 Manufacturing method of Nanaomycin A
GB7907887A GB2015526B (en) 1978-03-07 1979-03-06 Naphthopyrans

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53025042A JPS6016953B2 (en) 1978-03-07 1978-03-07 Manufacturing method of Nanaomycin A

Publications (2)

Publication Number Publication Date
JPS54119469A true JPS54119469A (en) 1979-09-17
JPS6016953B2 JPS6016953B2 (en) 1985-04-30

Family

ID=12154849

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53025042A Expired JPS6016953B2 (en) 1978-03-07 1978-03-07 Manufacturing method of Nanaomycin A

Country Status (2)

Country Link
JP (1) JPS6016953B2 (en)
GB (1) GB2015526B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478734A (en) * 1993-06-18 1995-12-26 Bristol-Myers Squibb Company Method of chiral epoxidation of benzopyran or pyranopyridine derivatives using microorganisms

Also Published As

Publication number Publication date
GB2015526A (en) 1979-09-12
GB2015526B (en) 1982-06-03
JPS6016953B2 (en) 1985-04-30

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