JPS54115311A - New derivative of 2'-n-substituted aminoglycoside - Google Patents

New derivative of 2'-n-substituted aminoglycoside

Info

Publication number
JPS54115311A
JPS54115311A JP2224778A JP2224778A JPS54115311A JP S54115311 A JPS54115311 A JP S54115311A JP 2224778 A JP2224778 A JP 2224778A JP 2224778 A JP2224778 A JP 2224778A JP S54115311 A JPS54115311 A JP S54115311A
Authority
JP
Japan
Prior art keywords
aminoglycoside
bacteria
acyl
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2224778A
Other languages
Japanese (ja)
Inventor
Kikuo Igarashi
Tsunetoshi Honma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP2224778A priority Critical patent/JPS54115311A/en
Publication of JPS54115311A publication Critical patent/JPS54115311A/en
Pending legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A derivative of 2'-N-substituted aminoglycoside of formula I (R1=H, OH; R2=H, alkyl; R3=alkyl, acyl, where R2 is H when R3 is acyl) and its salt.
EXAMPLE: 2'-N-Methyltobramycin.
USE: An antibacterial and a synthetic intermediate of aminoglycoside derivatives, e.g. tobramycin, kanamycin B, etc. It has an excellent antibacterial activity against gram positive (negative) bacteria, esp. against gram negative bacteria, and also has an excellent antibacterial activity not only against the known aminoglycoside- sensitive bacteria but also against resistant bacteria.
PROCESS: For example, a penta-N-azomethin, obtained by the reaction of a compound of formula II with an aldehyde, e.g. benzoaldehyde, in a medium, is acylated at the 2'-amino group with N-acyloxysuccinimide and then hydrolyzed with an acid to give a compound of formula I (R2=H, R3=acyl).
COPYRIGHT: (C)1979,JPO&Japio
JP2224778A 1978-02-27 1978-02-27 New derivative of 2'-n-substituted aminoglycoside Pending JPS54115311A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2224778A JPS54115311A (en) 1978-02-27 1978-02-27 New derivative of 2'-n-substituted aminoglycoside

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2224778A JPS54115311A (en) 1978-02-27 1978-02-27 New derivative of 2'-n-substituted aminoglycoside

Publications (1)

Publication Number Publication Date
JPS54115311A true JPS54115311A (en) 1979-09-07

Family

ID=12077454

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2224778A Pending JPS54115311A (en) 1978-02-27 1978-02-27 New derivative of 2'-n-substituted aminoglycoside

Country Status (1)

Country Link
JP (1) JPS54115311A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416237A (en) * 1992-06-02 1995-05-16 Bp Chemicals Limited Process for the production of acetic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416237A (en) * 1992-06-02 1995-05-16 Bp Chemicals Limited Process for the production of acetic acid

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