JPS54115311A - New derivative of 2'-n-substituted aminoglycoside - Google Patents
New derivative of 2'-n-substituted aminoglycosideInfo
- Publication number
- JPS54115311A JPS54115311A JP2224778A JP2224778A JPS54115311A JP S54115311 A JPS54115311 A JP S54115311A JP 2224778 A JP2224778 A JP 2224778A JP 2224778 A JP2224778 A JP 2224778A JP S54115311 A JPS54115311 A JP S54115311A
- Authority
- JP
- Japan
- Prior art keywords
- aminoglycoside
- bacteria
- acyl
- formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A derivative of 2'-N-substituted aminoglycoside of formula I (R1=H, OH; R2=H, alkyl; R3=alkyl, acyl, where R2 is H when R3 is acyl) and its salt.
EXAMPLE: 2'-N-Methyltobramycin.
USE: An antibacterial and a synthetic intermediate of aminoglycoside derivatives, e.g. tobramycin, kanamycin B, etc. It has an excellent antibacterial activity against gram positive (negative) bacteria, esp. against gram negative bacteria, and also has an excellent antibacterial activity not only against the known aminoglycoside- sensitive bacteria but also against resistant bacteria.
PROCESS: For example, a penta-N-azomethin, obtained by the reaction of a compound of formula II with an aldehyde, e.g. benzoaldehyde, in a medium, is acylated at the 2'-amino group with N-acyloxysuccinimide and then hydrolyzed with an acid to give a compound of formula I (R2=H, R3=acyl).
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2224778A JPS54115311A (en) | 1978-02-27 | 1978-02-27 | New derivative of 2'-n-substituted aminoglycoside |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2224778A JPS54115311A (en) | 1978-02-27 | 1978-02-27 | New derivative of 2'-n-substituted aminoglycoside |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54115311A true JPS54115311A (en) | 1979-09-07 |
Family
ID=12077454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2224778A Pending JPS54115311A (en) | 1978-02-27 | 1978-02-27 | New derivative of 2'-n-substituted aminoglycoside |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54115311A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5416237A (en) * | 1992-06-02 | 1995-05-16 | Bp Chemicals Limited | Process for the production of acetic acid |
-
1978
- 1978-02-27 JP JP2224778A patent/JPS54115311A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5416237A (en) * | 1992-06-02 | 1995-05-16 | Bp Chemicals Limited | Process for the production of acetic acid |
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