JPS5363351A - Nn*22aminoalicyclic group* arylacylamide and method for its production - Google Patents

Nn*22aminoalicyclic group* arylacylamide and method for its production

Info

Publication number
JPS5363351A
JPS5363351A JP13522777A JP13522777A JPS5363351A JP S5363351 A JPS5363351 A JP S5363351A JP 13522777 A JP13522777 A JP 13522777A JP 13522777 A JP13522777 A JP 13522777A JP S5363351 A JPS5363351 A JP S5363351A
Authority
JP
Japan
Prior art keywords
arylacylamide
production
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13522777A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0114231B2 (en, 2012
Inventor
Suzumusuzukobitsutsu Jieikobu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of JPS5363351A publication Critical patent/JPS5363351A/ja
Publication of JPH0114231B2 publication Critical patent/JPH0114231B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/26—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP13522777A 1976-11-12 1977-11-10 Nn*22aminoalicyclic group* arylacylamide and method for its production Granted JPS5363351A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/741,354 US4145435A (en) 1976-11-12 1976-11-12 2-aminocycloaliphatic amide compounds

Publications (2)

Publication Number Publication Date
JPS5363351A true JPS5363351A (en) 1978-06-06
JPH0114231B2 JPH0114231B2 (en, 2012) 1989-03-10

Family

ID=24980381

Family Applications (4)

Application Number Title Priority Date Filing Date
JP13522777A Granted JPS5363351A (en) 1976-11-12 1977-11-10 Nn*22aminoalicyclic group* arylacylamide and method for its production
JP61094401A Granted JPS61233654A (ja) 1976-11-12 1986-04-23 Ｎ‐（２アミノ脂環式族）‐アリールアシルアミド及びその製法
JP61094399A Granted JPS61243053A (ja) 1976-11-12 1986-04-23 Ｎ‐（２‐アミノ脂環式族）アリールアシルアミド及びその製法
JP61094400A Granted JPS61243054A (ja) 1976-11-12 1986-04-23 Ｎ‐（２‐アミノ脂環式族）アリールアシルアミド及びその製法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP61094401A Granted JPS61233654A (ja) 1976-11-12 1986-04-23 Ｎ‐（２アミノ脂環式族）‐アリールアシルアミド及びその製法
JP61094399A Granted JPS61243053A (ja) 1976-11-12 1986-04-23 Ｎ‐（２‐アミノ脂環式族）アリールアシルアミド及びその製法
JP61094400A Granted JPS61243054A (ja) 1976-11-12 1986-04-23 Ｎ‐（２‐アミノ脂環式族）アリールアシルアミド及びその製法

Country Status (12)

Country Link
US (1) US4145435A (en, 2012)
JP (4) JPS5363351A (en, 2012)
AU (1) AU510133B2 (en, 2012)
BE (1) BE860726A (en, 2012)
CA (1) CA1072958A (en, 2012)
CH (1) CH638777A5 (en, 2012)
DE (1) DE2749950A1 (en, 2012)
ES (1) ES463876A1 (en, 2012)
FR (1) FR2370723A1 (en, 2012)
GB (1) GB1569225A (en, 2012)
NL (1) NL7711998A (en, 2012)
ZA (1) ZA776241B (en, 2012)

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IT1090782B (it) * 1977-11-30 1985-06-26 Menarini Sas 2 4 bifenilil 2 dietilamino alchil propionamide suoi sali e procedimenti di fabbricazione relativi
US5234944A (en) * 1986-08-21 1993-08-10 Roussel Uclaf Novel indanes
US4735959A (en) * 1981-01-10 1988-04-05 Dr. Karl Thomae Gmbh Carboxylic acid amides and pharmaceutical compositions containing them
DE3100575A1 (de) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel"
US4466977A (en) * 1981-04-09 1984-08-21 The Upjohn Company N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics
US4460600A (en) * 1981-04-09 1984-07-17 The Upjohn Company Adjacently substituted ketal derivatives of cycloalkane-amide analgesics
US4360531A (en) * 1981-04-09 1982-11-23 The Upjohn Company Substituted cycloalkanes
US4359476A (en) * 1981-04-09 1982-11-16 The Upjohn Company Adjacently substituted cycloalkane-amide analgesics
US4438130A (en) * 1981-11-12 1984-03-20 The Upjohn Company Analgesic 1-oxa-, aza- and thia-spirocyclic compounds
US4540690A (en) * 1982-02-09 1985-09-10 The Upjohn Company 2-(Phenylmethylene)cycloalkylamines and -azetidines
US4463013A (en) * 1982-04-09 1984-07-31 The Upjohn Company Oxygen substituted amino-cyclohexyl-benzeneacetamides and -benzamides as water diuretic drugs
US4508911A (en) * 1982-06-21 1985-04-02 The Upjohn Company Amine intermediates for analgesic compounds
US4652559A (en) * 1982-08-16 1987-03-24 The Upjohn Company 2-(Phenylmethylene)cycloalkyl-azetidines
AT376669B (de) * 1982-11-26 1984-12-27 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thienylessigsaeureamid-derivate und pharmazeutisch vertraeglicher saeureadditionssalze davon
ZA842753B (en) * 1983-05-18 1984-11-28 Upjohn Co 2-dihydropyrrolyl-cycloalkyl-amide analgesics
US4598088A (en) * 1983-05-18 1986-07-01 The Upjohn Company 2-pyrrolyl-cycloalkyl-amide analgesics
US4560767A (en) * 1983-06-17 1985-12-24 The Upjohn Company N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom
US4656182A (en) * 1983-12-06 1987-04-07 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4579863A (en) * 1983-12-06 1986-04-01 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4598087A (en) * 1983-12-06 1986-07-01 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4588591A (en) * 1984-05-25 1986-05-13 The Upjohn Company Analgesic 2-oxa-spirocyclic compounds
US4632935A (en) * 1984-05-30 1986-12-30 The Upjohn Company Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and cycloalkenyl amides as analgesics
US4618621A (en) * 1984-09-21 1986-10-21 The Upjohn Company Method for treating medical conditions involving cerebral ischemia
US4738981A (en) * 1984-11-13 1988-04-19 Warner-Lambert Substituted trans-1,2-diaminocyclohexyl amide compounds
US4737493A (en) * 1985-07-01 1988-04-12 Warner-Lambert Company 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
EP0248824B1 (en) * 1985-10-25 1990-01-17 The Upjohn Company Use of cis-n-(2 aminocycloaliphatic) benzene acetamide and benzamide for the manufacture of anticonvulsants
US4663335A (en) * 1985-10-25 1987-05-05 The Upjohn Company Trans-(+)-2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]ac
US4801604A (en) * 1985-10-25 1989-01-31 The Upjohn Company Cis-N-(2-aminocycloaliphatic)benzamide anti-convulsants
ES2017932B3 (es) * 1985-12-23 1991-03-16 Dr Lo Zambeletti S P A Compuestos azaciclicos, procedimientos de su preparacion y su uso como farmacos.
US4988810A (en) * 1986-01-13 1991-01-29 Roussel Uclaf Novel hydroquinolines useful as intermediates
FR2592879B1 (fr) * 1986-01-13 1988-04-29 Roussel Uclaf Nouveaux derives de la decahydroquinoleine, leur procede de preparation, les intermediaires de preparation, leur application a titre de medicaments et les compositions les renfermant
US5010085A (en) * 1986-09-10 1991-04-23 E. I. Du Pont De Nemours And Company Benzo-fused cycloalkane and oxa- and thia-cycloalkane trans-1,2-diamine derivatives
US4876269A (en) * 1986-09-10 1989-10-24 E. I. Du Pont De Nemours And Company Benoz-fused cycloalkane trans-1,2-diamine derivatives
MY101368A (en) * 1986-09-10 1991-09-05 Bristol Myers Squibb Pharma Company Benzo-fused cyclaolkane and oxa-and thai,cycloalkane trans-1, 2-daimine derivatives
GB8801304D0 (en) * 1988-01-21 1988-02-17 Ici Plc Diamine compounds
US5229414A (en) * 1988-01-21 1993-07-20 Imperial Chemical Industries Plc Diamine compounds
FR2627491B1 (fr) * 1988-02-18 1992-01-24 Roussel Uclaf Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
US4891382A (en) * 1988-04-22 1990-01-02 The Upjohn Company Method of preventing pancreatitis utilizing 2-amino-cycloaliphatic amides
US5051428A (en) * 1988-12-06 1991-09-24 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
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JPH0641830U (ja) * 1992-11-12 1994-06-03 富士写真フイルム株式会社 フィルターユニット
US5475019A (en) * 1993-02-08 1995-12-12 East Carolina University Method of treating anxiety-related disorders with 2-aminocycloaliphatic amide compounds
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Also Published As

Publication number Publication date
JPS61233654A (ja) 1986-10-17
JPS61243054A (ja) 1986-10-29
JPH0114231B2 (en, 2012) 1989-03-10
AU2988177A (en) 1979-04-26
DE2749950C2 (en, 2012) 1988-02-25
US4145435A (en) 1979-03-20
AU510133B2 (en) 1980-06-12
NL7711998A (nl) 1978-05-17
ES463876A1 (es) 1979-01-01
CH638777A5 (de) 1983-10-14
GB1569225A (en) 1980-06-11
JPS6259103B2 (en, 2012) 1987-12-09
CA1072958A (en) 1980-03-04
JPS6259100B2 (en, 2012) 1987-12-09
DE2749950A1 (de) 1978-05-18
JPS6259101B2 (en, 2012) 1987-12-09
JPS61243053A (ja) 1986-10-29
BE860726A (fr) 1978-05-10
FR2370723B1 (en, 2012) 1980-08-22
FR2370723A1 (fr) 1978-06-09
ZA776241B (en) 1978-07-26

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