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Ono Pharmaceutical Co Ltd
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Ono Pharmaceutical Co Ltd
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Application filed by Ono Pharmaceutical Co LtdfiledCriticalOno Pharmaceutical Co Ltd
Priority to JP5127677ApriorityCriticalpatent/JPS53137952A/en
Publication of JPS53137952ApublicationCriticalpatent/JPS53137952A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PURPOSE: Prostagandin I2 analogous cpds. I (Y is trans-vinylene or ethylene; R1 is H or alkyl; R2 is H, methyl or ethyl; R3 is a direct bond or 1 - 4C alkylene; R4 is H, alkyl, phenyl, etc.; the dotted line is α-coordination, β-coordinatio or their mixture; the double bond between 2- and 3-positions is trans, and the double bond between 5- and 6-positions is Z) or their cyclodextrin inclusion cpds. and nontoxic salts, e.g. (2E, 5Z, 13E) - (9α, 11α, 15S) -6,9-epoxy-11,15-dihydroxyprosta-2,5,13-tienic acid methylester.
COPYRIGHT: (C)1978,JPO&Japio
JP5127677A1977-05-061977-05-06Prostaglandin 1 l2 analogous compounds and process for their preparation
PendingJPS53137952A
(en)
Prostaglandins and prostacyclins substituted by n-containing unsaturated heterocyclin derivatives,processes for their preparation and pharmaceutical compositions containing same