JPS52122373A - Nicotinic acid amide derivatives - Google Patents

Nicotinic acid amide derivatives

Info

Publication number
JPS52122373A
JPS52122373A JP3610176A JP3610176A JPS52122373A JP S52122373 A JPS52122373 A JP S52122373A JP 3610176 A JP3610176 A JP 3610176A JP 3610176 A JP3610176 A JP 3610176A JP S52122373 A JPS52122373 A JP S52122373A
Authority
JP
Japan
Prior art keywords
acid amide
nicotinic acid
amide derivatives
derivatives
hydroxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3610176A
Other languages
Japanese (ja)
Other versions
JPS5817463B2 (en
Inventor
Hiroyuki Nagano
Mutsuji Mori
Sakae Takaku
Isao Matsunaga
Tatsuo Kujirai
Toshichika Ogasawara
Shigeru Sugano
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP51036101A priority Critical patent/JPS5817463B2/en
Priority to AU23532/77A priority patent/AU509591B2/en
Priority to DK128277A priority patent/DK145608C/en
Priority to CA274,696A priority patent/CA1088944A/en
Priority to GB1254177A priority patent/GB1562962A/en
Priority to MX559377U priority patent/MX5534E/en
Priority to MX1052777U priority patent/MX7103E/en
Priority to ES457421A priority patent/ES457421A1/en
Priority to ZA00771976A priority patent/ZA771976B/en
Priority to CH415377A priority patent/CH633535A5/en
Priority to DE19772714713 priority patent/DE2714713C3/en
Priority to CS772189A priority patent/CS228104B2/en
Priority to SE7703868A priority patent/SE436029B/en
Priority to BE2055790A priority patent/BE853144A/en
Priority to AR26709977A priority patent/AR217423A1/en
Priority to FI771024A priority patent/FI66598C/en
Priority to SU772467501A priority patent/SU999965A3/en
Priority to FR7710119A priority patent/FR2346334A1/en
Priority to NL7703624A priority patent/NL176674C/en
Priority to AT235077A priority patent/AT360532B/en
Priority to HU77CU155A priority patent/HU174118B/en
Publication of JPS52122373A publication Critical patent/JPS52122373A/en
Priority to AR27116278A priority patent/AR220907A1/en
Priority to ES468462A priority patent/ES468462A1/en
Priority to SU782640400A priority patent/SU942593A3/en
Priority to US05/940,194 priority patent/US4200640A/en
Priority to CS787549A priority patent/CS228111B2/en
Priority to AT286979A priority patent/AT360536B/en
Publication of JPS5817463B2 publication Critical patent/JPS5817463B2/en
Priority to NL930042C priority patent/NL930042I2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

PURPOSE: N-(2-hydroxyethyl) nicotinic acid amide nitric acid ester or its salt I.
COPYRIGHT: (C)1977,JPO&Japio
JP51036101A 1976-04-02 1976-04-02 Nicotinic acid amide derivatives Expired JPS5817463B2 (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
JP51036101A JPS5817463B2 (en) 1976-04-02 1976-04-02 Nicotinic acid amide derivatives
AU23532/77A AU509591B2 (en) 1976-04-02 1977-03-23 Pyridine derivatives
DK128277A DK145608C (en) 1976-04-02 1977-03-23 ANALOGY PROCEDURE FOR PREPARING THE NICKETIC ACID ESTER OF N- (2-HYDROXYETHYL) NICOTINAMIDE
CA274,696A CA1088944A (en) 1976-04-02 1977-03-24 Nitric ester of n-(2-hydroxyethyl)nicotinamide and a process for the preparation of same
GB1254177A GB1562962A (en) 1976-04-02 1977-03-24 Nicotinamide derivatives processes for producting the same and pharmaceutical compositions containing the same
MX559377U MX5534E (en) 1976-04-02 1977-03-30 PROCEDURE FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES
MX1052777U MX7103E (en) 1976-04-02 1977-03-30 PROCEDURE FOR PREPARING NICOTINAMIDE DERIVATIVES
ES457421A ES457421A1 (en) 1976-04-02 1977-03-31 A procedure for the preparation of new derivatives of pyridine. (Machine-translation by Google Translate, not legally binding)
ZA00771976A ZA771976B (en) 1976-04-02 1977-03-31 Novel pyridine derivative,process for preparing the same and pharmaceutical composition containing the same
FI771024A FI66598C (en) 1976-04-02 1977-04-01 FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ANVAENDBARA SAPETERSYRAESTRAR AV N- (HYDROXIALKYL) PYRIDINKARBOXAMIDDERIV AT
DE19772714713 DE2714713C3 (en) 1976-04-02 1977-04-01 Nitric acid ester of N- (2-HydroxyäthyO-nicotinamide, process for its preparation and pharmaceuticals
CS772189A CS228104B2 (en) 1976-04-02 1977-04-01 Preparation of esters of nitric acid and n-/2-hydroxyethyl/nicotinamides
SE7703868A SE436029B (en) 1976-04-02 1977-04-01 Process for the preparation of the nitric acid ester of N- (2-hydroxyethyl) nicotinamide
BE2055790A BE853144A (en) 1976-04-02 1977-04-01 NEW DERIVATIVE OF PYRIDINE, PROCESS FOR ITS PHARMACEUTICAL COMPOSITION CONTAINING THIS DERIVATIVE
AR26709977A AR217423A1 (en) 1976-04-02 1977-04-01 PREPARATION PROCEDURE FOR N- (2-HYDROXYETHYL) -NICOTINAMIDE NITRIC ESTERS
CH415377A CH633535A5 (en) 1976-04-02 1977-04-01 Process for the preparation of pyridine derivatives.
SU772467501A SU999965A3 (en) 1976-04-02 1977-04-01 Process for producing n-(2-oxyethyl)-nicotine-amide nitric acid ester or its salts
FR7710119A FR2346334A1 (en) 1976-04-02 1977-04-04 NEW DERIVATIVES OF PYRIDINE, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS
NL7703624A NL176674C (en) 1976-04-02 1977-04-04 METHOD FOR PREPARING A MEDICINE FOR THE TREATMENT OF CIRCULATION MALFUNCTIONS AND METHOD FOR PREPARING THE MEDICINAL COMPOUNDS.
AT235077A AT360532B (en) 1976-04-02 1977-04-04 METHOD FOR PRODUCING THE NEW SALPETER ACID ESTER OF N- (2-HYDROXYAETHYL) NICOTINAMIDE UNDER THE SAME SALTS
HU77CU155A HU174118B (en) 1976-04-02 1977-09-01 Process for preparing new n-/2-hydroxy-ethyl/-nicotinamidyl-nitric acid esters and salts thereof
AR27116278A AR220907A1 (en) 1976-04-02 1978-02-20 PREPARATION PROCEDURE FOR N- (2-HYDROXYETHYL) NICOTINAMIDE NITRIC ESTERS
ES468462A ES468462A1 (en) 1976-04-02 1978-03-31 A procedure for the preparation of new derivatives of pyridine. (Machine-translation by Google Translate, not legally binding)
SU782640400A SU942593A3 (en) 1976-04-02 1978-07-28 Process for producing nitric acid ester of n-(2-oxyethyl)-nicotineamide or its salts
US05/940,194 US4200640A (en) 1976-04-02 1978-09-07 Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
CS787549A CS228111B2 (en) 1976-04-02 1978-11-20 Preparation of esters of nitric acid and n/2-hydroxyethyl/-nicotinamides
AT286979A AT360536B (en) 1976-04-02 1979-04-17 METHOD FOR PRODUCING THE NEW SALPETER ACID ESTER OF N- (2-HYDROXYAETHYL) NICOTINAMIDE AND ITS SALTS
NL930042C NL930042I2 (en) 1976-04-02 1993-05-28 A method of preparing a medicament for the treatment of circulatory disorders and a method of preparing the medicinal compounds.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51036101A JPS5817463B2 (en) 1976-04-02 1976-04-02 Nicotinic acid amide derivatives

Publications (2)

Publication Number Publication Date
JPS52122373A true JPS52122373A (en) 1977-10-14
JPS5817463B2 JPS5817463B2 (en) 1983-04-07

Family

ID=12460366

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51036101A Expired JPS5817463B2 (en) 1976-04-02 1976-04-02 Nicotinic acid amide derivatives

Country Status (5)

Country Link
JP (1) JPS5817463B2 (en)
BE (1) BE853144A (en)
CS (1) CS228104B2 (en)
SU (2) SU999965A3 (en)
ZA (1) ZA771976B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10550086B1 (en) 2018-12-25 2020-02-04 Institute Of Applied Biochemistry Lenvatinib derivative, and composition for pharmaceutical research and tumor therapeutic agent using the same

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192562U (en) * 1983-06-07 1984-12-20 四国化成工業株式会社 pillar

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10550086B1 (en) 2018-12-25 2020-02-04 Institute Of Applied Biochemistry Lenvatinib derivative, and composition for pharmaceutical research and tumor therapeutic agent using the same

Also Published As

Publication number Publication date
ZA771976B (en) 1978-03-29
JPS5817463B2 (en) 1983-04-07
CS228104B2 (en) 1984-05-14
BE853144A (en) 1977-08-01
SU999965A3 (en) 1983-02-23
SU942593A3 (en) 1982-07-07

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term
R154 Certificate of patent or utility model (reissue)

Free format text: JAPANESE INTERMEDIATE CODE: R154