JPS5212144A - Production of phenylacetic acid derivatives and pharmaceutical agent having blood sugagar and lipid lowerling activities - Google Patents

Production of phenylacetic acid derivatives and pharmaceutical agent having blood sugagar and lipid lowerling activities

Info

Publication number
JPS5212144A
JPS5212144A JP51077696A JP7769676A JPS5212144A JP S5212144 A JPS5212144 A JP S5212144A JP 51077696 A JP51077696 A JP 51077696A JP 7769676 A JP7769676 A JP 7769676A JP S5212144 A JPS5212144 A JP S5212144A
Authority
JP
Japan
Prior art keywords
sugagar
lowerling
lipid
activities
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP51077696A
Other languages
English (en)
Inventor
Hiyuupunaa Manfureeto
Kiyuunre Hansu
Kurisuchiyan Buitsute Erunsuto
Heeruto Ruuto
Buaieru Rudei
Hitsutsueru Fuorukeru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of JPS5212144A publication Critical patent/JPS5212144A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
JP51077696A 1975-07-19 1976-06-30 Production of phenylacetic acid derivatives and pharmaceutical agent having blood sugagar and lipid lowerling activities Pending JPS5212144A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752532420 DE2532420A1 (de) 1975-07-19 1975-07-19 Phenylessigsaeure-derivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
JPS5212144A true JPS5212144A (en) 1977-01-29

Family

ID=5951971

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51077696A Pending JPS5212144A (en) 1975-07-19 1976-06-30 Production of phenylacetic acid derivatives and pharmaceutical agent having blood sugagar and lipid lowerling activities

Country Status (13)

Country Link
US (2) US4207341A (ja)
JP (1) JPS5212144A (ja)
AT (1) AT343637B (ja)
BE (1) BE843685A (ja)
CA (1) CA1076126A (ja)
DE (1) DE2532420A1 (ja)
DK (1) DK297076A (ja)
FR (1) FR2318627A1 (ja)
GB (1) GB1511095A (ja)
HU (1) HU172453B (ja)
IE (1) IE43142B1 (ja)
LU (1) LU75270A1 (ja)
NL (1) NL7607159A (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS575853A (en) * 1980-06-13 1982-01-12 Nisshin Steel Co Ltd Continuous hot-dip coating apparatus
JPS5763603A (en) * 1980-10-02 1982-04-17 Sumitomo Electric Ind Ltd Manufacture of cylinder liner
JPS6223906A (ja) * 1985-05-23 1987-01-31 インコ、アロイス、インタ−ナシヨナル、インコ−ポレ−テツド ガス微粒化粉末のカン不使用の熱間加工法
JPH01208813A (ja) * 1988-02-17 1989-08-22 Matsushita Electric Ind Co Ltd 希土類磁石の製造方法
JPH01316401A (ja) * 1988-06-16 1989-12-21 Sanyo Special Steel Co Ltd 粉末材料の加圧焼結方法
JP2008189366A (ja) * 2007-02-06 2008-08-21 Toppan Printing Co Ltd 紙製包装容器

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77316A1 (ja) * 1977-05-11 1979-01-19
LU79008A1 (de) * 1978-02-03 1979-09-06 Byk Gulden Lomberg Chem Fab W-(n-alkyl-n-benzoyl-amino)-phenylalkansaeuren,ihre verwendung und herstellung sowie sie enthaltende arzneimittel
US4281018A (en) * 1978-04-12 1981-07-28 American Cyanamid Company Novel 4-[(carboxyl- and sulfamyl-substituted alkyl)-amino]benzoic acids and analogs
DE2948056A1 (de) * 1979-11-29 1981-06-04 Boehringer Mannheim Gmbh, 6800 Mannheim Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS56145261A (en) * 1980-04-10 1981-11-11 Kaken Pharmaceut Co Ltd Novel oxyacetic acid derivative, its preparation, and lowering agent of lipid in blood comprising it as active ingredient
US5274000A (en) * 1982-10-19 1993-12-28 Kotobuki Seiyaku Company Limited Benzofuran and benzothiophene derivatives, anti-hyperuricemia agents
IT1177966B (it) * 1984-08-14 1987-09-03 Medosan Ind Biochimi Derivati amidici dell'acido 2-(p-aminobenzil)butirrico e relativi e-steri provvisti di attivita' ipolipidemizzante
IT1199652B (it) * 1985-01-28 1988-12-30 Boehringer Biochemia Srl Composti ad attivita'antiiperlipidemica,loro preparazione e composizioni farmaceutiche che li contengono
US4689182A (en) * 1985-12-20 1987-08-25 Warner-Lambert Company Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
US5227511A (en) * 1988-12-23 1993-07-13 Hodogaya Chemical Co., Ltd. Benzamide derivatives and plant growth regulants containing them
US5210212A (en) * 1991-06-25 1993-05-11 Pfizer Inc Process for 5-fluoro-6-chlorooxindole
US5166401A (en) * 1991-06-25 1992-11-24 Pfizer Inc Intermediates for 5-fluoro-6-chlorooxindole
US6916489B2 (en) 1992-06-15 2005-07-12 Emisphere Technologies, Inc. Active agent transport systems
TW279845B (ja) * 1992-12-01 1996-07-01 Ciba Geigy Ag
US20010003001A1 (en) 1993-04-22 2001-06-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
IL126318A (en) 1996-03-29 2004-09-27 Emisphere Tech Inc Compounds and compositions for delivering active agents and some novel carrier compounds
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
AU4216700A (en) * 1999-04-05 2000-10-23 Emisphere Technologies, Inc. Disodium salts, monohydrates, and ethanol solvates
EP1237872B1 (en) 1999-12-16 2008-02-27 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
JP2005209106A (ja) * 2004-01-26 2005-08-04 Nec Corp 携帯通信端末、受信メール管理方法、プログラムおよび記録媒体
WO2012003145A2 (en) * 2010-07-02 2012-01-05 Allergan, Inc. Therapeutic agents for ocular hypertension
US9714238B2 (en) 2010-07-02 2017-07-25 Allergan, Inc. Therapeutic agents for ocular hypertension

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3629450A (en) * 1970-01-16 1971-12-21 Ciba Geigy Corp O-(substituted benzamido) phenylacetic acids as anti-inflammatory agents
DE2230383C3 (de) * 1971-10-01 1981-12-03 Boehringer Mannheim Gmbh, 6800 Mannheim Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben
DE2320387A1 (de) * 1973-04-21 1974-10-31 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben
DE2500157C2 (de) * 1975-01-03 1983-09-15 Hoechst Ag, 6230 Frankfurt N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung
DK148576A (da) * 1975-04-18 1976-10-19 Boehringer Mannheim Gmbh Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS575853A (en) * 1980-06-13 1982-01-12 Nisshin Steel Co Ltd Continuous hot-dip coating apparatus
JPS5763603A (en) * 1980-10-02 1982-04-17 Sumitomo Electric Ind Ltd Manufacture of cylinder liner
JPS6312121B2 (ja) * 1980-10-02 1988-03-17 Sumitomo Electric Industries
JPS6223906A (ja) * 1985-05-23 1987-01-31 インコ、アロイス、インタ−ナシヨナル、インコ−ポレ−テツド ガス微粒化粉末のカン不使用の熱間加工法
JPH0225961B2 (ja) * 1985-05-23 1990-06-06 Inco Alloys Int
JPH01208813A (ja) * 1988-02-17 1989-08-22 Matsushita Electric Ind Co Ltd 希土類磁石の製造方法
JPH01316401A (ja) * 1988-06-16 1989-12-21 Sanyo Special Steel Co Ltd 粉末材料の加圧焼結方法
JP2008189366A (ja) * 2007-02-06 2008-08-21 Toppan Printing Co Ltd 紙製包装容器

Also Published As

Publication number Publication date
FR2318627A1 (fr) 1977-02-18
HU172453B (hu) 1978-09-28
US4207341A (en) 1980-06-10
BE843685A (fr) 1977-01-03
IE43142L (en) 1977-01-19
IE43142B1 (en) 1980-12-31
NL7607159A (nl) 1977-01-21
ATA482676A (de) 1977-10-15
CA1076126A (en) 1980-04-22
AT343637B (de) 1978-06-12
US4278680A (en) 1981-07-14
DK297076A (da) 1977-01-20
GB1511095A (en) 1978-05-17
DE2532420A1 (de) 1977-02-03
FR2318627B1 (ja) 1978-11-17
LU75270A1 (ja) 1977-02-23

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