JPH119707A - Photodynamic therapeutic device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To satisfactorily observe a subject while keeping the state improved in photodynamic therapeutic effect by providing a filter driving means for inclining a filter means held on the image pickup surface side of an image pickup means in such a manner as to be capable of inclining at an optional angle to the optical axis at a prescribed angle to the optical axis. SOLUTION: A therapeutic laser beam is irradiated to the focal part of subject 120 while changing the wavelength, and the reflected light is received by a laser probe 21 to measure its intensity. On the basis of the intensity of the reflected laser beam, the maximum absorption wavelength of the light in the photosensitive material of the focal part is judged, and the wavelength of the therapeutic laser beam is set to this wavelength. Further, a laser beam cut filter 13 is rotated by a filter driving means 15 according to the change of the wavelength of the laser beam generated from a laser beam source, and controlled so as to change the wavelength band imaged on the image pickup surface of an image pickup element 12. Thus, the subject image can be displayed as a satisfactory image on a display device without being influenced by the therapeutic laser beam.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a method for irradiating a lesion in which a photosensitizer having an affinity for a tumor is accumulated with light corresponding to the absorption wavelength of the photosensitizer to excite the photosensitizer, The present invention relates to a photodynamic therapy device for treating a lesion.

[0002]

2. Description of the Related Art In recent years, a photosensitizer having an affinity for a tumor is administered to a subject, a laser beam corresponding to the absorption wavelength of the photosensitizer is irradiated, and a photochemical reaction is used to treat the tumor. Photodynamic therapy (PDT)
However, it is attracting attention as a new treatment for cancer.

[0003] Unlike photo-surgery, this photodynamic therapy can be performed with little effect on normal tissues, and is said to have a high quality of life after surgery.
Therefore, various developments have been made on photodynamic therapy.

For example, Japanese Patent Application Laid-Open No. 6-222 proposes a laser generator for a medical device, which focuses on the fact that the optimal therapeutic laser beam wavelength differs depending on the patient and the affected area, and further enhances the therapeutic effect. I have.

[0005] That is, the absorption wavelength of the photosensitizer shifts to the longer wavelength side due to the coupling with the living tissue, and this shift differs depending on the tissue. Can be

For this reason, the lesion is irradiated with the therapeutic laser light while changing the wavelength within a predetermined range, the amount of active oxygen generated is monitored, and the amount of active oxygen generated is increased so as to increase the amount of active oxygen generated. We have proposed a laser generator for medical devices that sets the wavelength.

In Japanese Patent Application Laid-Open No. Hei 6-246014, it is noted that it is difficult to control the wavelength of laser light with a conventional medical laser device, and a semiconductor laser is used for the medical laser device. It has been proposed to control the wavelength of laser light by controlling the temperature of the semiconductor laser.

On the other hand, in an electronic endoscope having a treatment function using laser light, the laser light used for treatment is strongly reflected.
The laser light causes a defect in the observation image, which is a problem.

For this reason, as disclosed in, for example, Japanese Patent Application Laid-Open No. 1-265934, in order to prevent laser light from being incident on the light receiving surface of the image pickup device, a specific range corresponding to the laser light to be used is used. It has been proposed to provide a filter that cuts off the wavelength integrally with the objective lens.

[0010]

As described above, an electronic endoscope having a laser beam treatment function is provided with a filter for preventing the influence of the reflection of the treatment laser beam.

However, this filter uses a filter that sharply blocks only the vicinity of the wavelength of the therapeutic laser light. Therefore, in photodynamic therapy,
When the lesion is irradiated while changing the wavelength of the therapeutic laser beam to improve the therapeutic effect, the wavelength of the therapeutic laser deviates from the wavelength range that can be cut off by the filter, and a normal subject image is observed. The inability to do so occurs.

On the other hand, it is conceivable to provide a filter on the front surface of the imaging means which can block the entire wavelength range in which the therapeutic laser changes. However, the wavelength of the treatment laser used for the treatment laser is generally a wavelength in the red band. Therefore, if the entire variable wavelength range of the therapeutic laser beam is blocked, the red information is lost, which makes it unsuitable for performing in-vivo observation.

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned problems. By changing the wavelength of a therapeutic laser beam, it is possible to maintain a state in which the photodynamic therapeutic effect is improved while maintaining a good condition of the subject. It is an object of the present invention to provide a photodynamic therapy device capable of observation.

[0014]

According to the present invention, there is provided an image pickup means for picking up an image of an object, a display means for displaying the image of the object based on an output signal of the image pickup means, and a laser beam applied to the object. A laser beam irradiating means for irradiating the light beam, wherein a filter means held on the imaging surface side of the imaging means so as to be tiltable at an arbitrary angle with respect to an optical axis, and Filter driving means for tilting the filter at a predetermined angle.

[0015]

Embodiments of the present invention will be described below with reference to the drawings. (First Embodiment) FIGS. 1 to 3 relate to a first embodiment of the present invention. FIG. 1 is a view showing the overall configuration of a photodynamic therapy apparatus for performing photodynamic therapy, and FIG. FIG. 3 is a cross-sectional view of the distal end of the insertion portion of the electronic endoscope that forms a part of the mechanical treatment device. FIG. FIG.

As shown in FIG. 1, a photodynamic therapy device 1
Is an electronic endoscope 2 inserted into the subject, a light source device 3 and a video processor 4 connected to the electronic endoscope 2, and a display device 5 connected to the video processor 4 and displaying an endoscope image. And a laser light generator 6 for generating laser light for treatment.

The light source device 3 is connected to a connector (not shown) of the electronic endoscope 2 in a detachable manner and generates white light for illuminating the subject. The white light generated by the light source device 3 is transmitted to the distal end of the insertion section 8 via the light guide fiber 7 provided in the electronic endoscope 2.

The white light transmitted to the distal end of the insertion section 8 by the light guide fiber 7 is illuminated on the subject 10 via the illumination lens 9 provided at the distal end of the insertion section 8. The image of the subject 10 illuminated with the white light is formed on the imaging surface of the imaging element 12 by the objective lens 11 provided at the tip of the insertion section 8.

As will be described in detail later, a laser light cut-fill 13 for cutting laser light is provided between the objective lens 11 and the image pickup device 12. Image sensor 1
The imaging signal photoelectrically converted in 2 is input to the video processor 4 via the signal line 14. Note that the signal line 14 is
The connector is detachably connected to the video processor 4 by a connector (not shown).

The video processor 4 performs video processing on the image signal output from the image sensor 12 and outputs the processed image to the display device 5. The display device 5 displays the subject image as an endoscope image based on the signal output from the video processor 4.

The laser light cut filter 13 provided at the tip of the insertion section 8 is provided with a filter driving means 15 for moving the laser light cut filter 13 as will be described later in detail.

The filter driving means 15 is connected via a signal line 17 to a filter control section 16 provided in the laser light generator 6 for controlling this movement. The filter control unit 16 has a function of controlling the operation state of the filter driving unit 15 to control the movement of the laser light cut filter 13.

The electronic endoscope 2 has a treatment instrument insertion port 18 for inserting a treatment instrument. This treatment instrument insertion port 18
The laser light probe 21 is integrally inserted with the laser light generating device 6 and the light guide probe 19 and the light receiving probe 20 which are detachably connected by a connector (not shown).

Each of the light guiding probe 19 and the light receiving probe 20 is composed of an optical fiber for guiding a laser beam. The light guide probe 19 applies the laser light generated by the laser light source 22 provided in the laser light generator 6 to the subject 1.
This leads to a lesion of zero.

The light receiving probe 20 irradiates with the light guide probe 19, receives the laser light reflected by the subject 10, and sends the laser light to the laser light detection sensor 23 provided in the laser light generator 6. It is for guiding.

The tip of the laser light probe 21 is
As shown in FIG. 2, the distal end of the light guide probe 19 is protruded from the distal end of the light receiving probe 20 so that the treatment laser light can be easily guided to the lesion.

The laser light source 22 for generating laser light is composed of a semiconductor laser. The laser light source 22 using this semiconductor laser generates, for example, a treatment laser beam of about 670 nm in a normal state.

The laser light source 22 is a laser light source 1.
2 is connected to a wavelength controller 24 for controlling the wavelength of the laser light generated from the laser light 2. The wavelength control unit 24 controls the laser light source 22 thermally. That is, the wavelength control unit 24 has a function of freely controlling the wavelength of the laser light generated from the laser light source 22 by controlling the temperature of the laser light source 22 composed of a semiconductor laser.

Here, as described above, the laser beam generated at a wavelength of about 670 nm in a normal state has a wavelength of about 620 nm by thermal control by the wavelength control unit 24.
The variable control is continuously performed up to m.

The wavelength controller 24 is connected to a wavelength determiner 25 having a function of determining the wavelength of the laser light generated by the laser light source 22. This wavelength determining unit 25
The wavelength of the laser light generated by the laser light source 22 is determined according to the intensity of the laser light detected by the laser light detection sensor 23.

Specifically, when the subject is irradiated with the therapeutic laser beam and the conditions such as the distance relationship are the same, the less the laser beam is reflected from the subject 10, the more the laser beam is reflected. It can be determined that it efficiently contributes to the treatment of the lesion.

That is, by selecting the wavelength of the laser beam at which the intensity of the laser beam reflected from the subject 10 becomes weak, it can be seen that more effective treatment is being performed. Therefore, the wavelength determining unit 25 sets the laser light detection sensor 2
Based on the output signal of the laser beam intensity detected in step 3, the operation of the wavelength control unit 24 is controlled so that the output value becomes small.

The wavelength control unit 24 controls the temperature of the laser beam 22 based on the output signal from the wavelength determination unit 25, and controls the wavelength of the generated laser beam. The feedback control is performed so that the output signal of the laser light detection sensor 23 is minimized in these circuits as a whole.

The wavelength determining section 25 is also configured to control the operation of the filter control section 16 based on the output signal of the laser light detection sensor 23. The control of the filter control unit 16 by the wavelength determination unit 25 is performed by the wavelength control unit 2.
This is synchronized with the wavelength control of the laser beam by the control of (4).

Next, the configuration of the distal end of the electronic endoscope 2 will be described with reference to FIG. As described above, the laser light cut filter 13 for blocking the laser light is provided between the objective lens 11 and the imaging element 12.

The laser light cut filter 13 is constituted by an interference filter. In general, the interference filter changes the wavelength at which light is blocked depending on the incident angle. FIG. 3 shows an example of the characteristics.

It is assumed that the light transmission characteristics when light enters the interference filter at right angles are, for example, the characteristics shown by the solid line (a) in FIG. That is, in order to cut off the treatment laser beam, the wavelength in a narrow band around about 670 nm is cut off.

On the other hand, when the incident angle of the light is inclined by θ, the light transmission characteristic changes as shown by a broken line (b). The cutoff wavelength by the interference filter has a characteristic that changes with a specific relationship according to the incident angle of the light.

That is, it is possible to specify which wavelength band is cut off when light is incident on an interference filter designed to block a specific wavelength band.

The photodynamic therapy device 1 of the first embodiment
In order to make use of this characteristic, the laser light cut filter 13 composed of an interference filter is rotatably held by a bearing (not shown) at the tip of the insertion portion 8, and the laser light cut filter 13. A guide rail 27 for restricting the rotation of the guide rail 27 is provided.

However, in order to be able to confirm the irradiation position of the therapeutic laser light during treatment with the laser light, the laser light cut filter 13 has a transmittance of 5 to 10% even in a wavelength band cut off by the laser light cut filter 13. It is desirable to secure

The laser light cut filter 13 held rotatably is connected to a filter driving means 15 composed of an actuator capable of generating a driving force such as a shape memory alloy.

The laser light cut filter 13
Can use a holographic notch filter instead of an interference filter. By driving the filter driving means 15, the tilt angle of the laser light cut filter 13 held rotatably can be controlled.

The rotation range of the laser light cut filter 13 is set to a range in which the wavelength of the laser light output from the laser light source 22 can be cut off in accordance with the change range of the wavelength.

As described above, under the control of the filter controller 16, the filter driving means 15 causes the laser light cut filter 1
3 is configured to rotate like a broken line (c).

Next, the operation of the photodynamic therapy device 1 configured as described above will be described. First, the insertion section 8 is inserted into the subject based on white light generated by the light source device 3 in order to guide the electronic endoscope 2 to a lesion to be subjected to photodynamic therapy.

The image pickup device 12 converts the object image illuminated with white light into the objective lens 11 and the laser light cut filter 1.
3 is imaged. The laser light cut filter 13 is
As shown in FIG. 3, the laser light generally has a characteristic of blocking a narrow wavelength range of about 670 nm. Even if an image of a subject is captured through the laser light cut filter 13, the image is not affected at all. Absent.

After confirming from the endoscope image displayed on the display device 5 that the distal end of the insertion section 8 is located near the lesion, preparations for performing treatment with laser light are made. The lesion is preliminarily treated to accumulate the photosensitizer.

Then, in order to perform treatment by laser light,
The laser light generator 6 is inserted into the treatment tool insertion port 18 of the electronic endoscope 2.
Is inserted through the laser light probe 21 connected to the. After observing the endoscope image displayed on the display device 5 and confirming that the tip of the laser light probe 21 faces the lesion, the laser light generator 6 was driven to generate the laser light generated by the laser light source 22. The lesion is irradiated with laser light.

The irradiation of the laser beam excites the photosensitizer at the lesion, thereby performing photodynamic therapy. At this time, the treatment laser light is, as shown in FIG.
The light is reflected from the surface of the subject 10.

The laser beam reflected by the objective lens 11 is about to form an image on the imaging surface side of the imaging device 12. However, as described above, on the imaging surface side of the imaging device 12,
A laser light cut filter 13 is provided, and the laser light cut filter 13 is positioned by the filter driving means 15 so as to have an angle at which the wavelength of the laser light generated from the laser light source 12 is cut off.

Therefore, the laser light reflected on the surface of the subject 10 is not picked up by the image pickup device 12, but picks up an image of the subject 10 based on white light and displays the image on the display device 5. I do.

The laser light reflected on the surface of the subject 10 is also received on the end face of the light receiving probe 20 of the laser light probe 21. The laser light received by the light receiving probe 20 is propagated to a laser light detection sensor 23 provided in the laser light generator 6, and its intensity is measured.

The intensity of the laser light measured by the laser light detection sensor 23 is input to the wavelength determining unit 25. When the intensity of the laser light is input, the wavelength determining unit 25 outputs a control signal to the wavelength control unit 24 so as to change the wavelength of the therapeutic laser light.

The control signal is for gradually changing the wavelength of the treatment laser beam from 670 nm to 620 nm, for example. At the same time, a control signal is also output to the filter control unit 16, and the laser cut filter 13 is also rotated by the filter driving unit 15 to set an angle at which the wavelength of the therapeutic laser light can be cut off.

The wavelength determining section 25 stores the respective light intensities when the wavelength of the treatment laser light is changed based on the output signal of the laser light detection sensor 23, and performs treatment when the reflection intensity becomes the weakest. The set wavelength of the laser light for use is determined.

After the set wavelength at which the reflection intensity becomes the weakest is determined, the wavelength determining unit 25 controls the wavelength control unit 24 so that laser light is generated at the set wavelength. , The operating state of the laser light source 22 is controlled.

After the photodynamic treatment with the laser beam has been performed for a predetermined time, the treatment is terminated.

As described above, according to the photodynamic therapy apparatus 1 of the first embodiment, the lesion of the subject 10 is irradiated with the treatment laser beam while changing the wavelength, and the reflected laser beam is reflected. The light is received by the laser probe 21 and its intensity is measured. Then, based on the intensity of the reflected laser light, the maximum absorption wavelength of light in the photosensitizer at the lesion is determined, and the wavelength of the therapeutic laser light is set to that wavelength. Thereby, the photodynamic treatment effect of the lesion can be improved.

Further, in response to changing the wavelength of the laser light generated from the laser light source 22 as described above, the laser light cut filter 13 is rotated by the filter driving means 15, and the image pickup surface of the image pickup device 12 is obtained. Is controlled so as to change the wavelength band of the light to be imaged on the.

Therefore, the subject image picked up by the image pickup device 12 is displayed on the display device 5 as a good image in which the color of the endoscope image is not largely disturbed without being affected by the treatment laser beam. . Diagnosis and treatment can be performed while observing the good image, so that the operability is also improved.

As described above, the laser beam cut filter 13 is configured to cut off the treatment laser beam.
Is merely allowed to rotate. Therefore, it is needless to say that the apparatus can be downsized as compared with the case where a plurality of laser light cut filters are provided corresponding to the wavelength of the therapeutic laser light.

Further, according to the photodynamic therapy apparatus 1 of the first embodiment, the laser beam automatically has an optimal therapeutic effect regardless of the tissue of the subject or the type of the administered photosensitive substance. Since the wavelength is selected and the endoscopic image at the time of the treatment is obtained as a good image, the efficiency of the photodynamic treatment can be improved.

In the photodynamic therapy apparatus 1 according to the first embodiment, the laser light source 22 is constituted by a laser diode, and it has been described that the laser light source can emit laser beams of different wavelengths by itself. Instead, a laser beam having a plurality of laser beams having wavelengths corresponding to the respective photosensitive materials may be used.

In the first embodiment, the photodynamic therapy device 1 has been described as using the electronic endoscope 2. However, the present invention is not limited to this. Can be applied. An example thereof will be described as a first modified example with reference to FIG.

The photodynamic therapy device 28 of the first modified example
Has a fiberscope 29 and an external camera 31 connected to an eyepiece 30 of the fiberscope 29 as shown in FIG.

The external camera 31 is detachably connected to the eyepiece 30 by a detachable mechanism 32.
Inside the external camera 31, there is provided an imaging lens 35 that forms an image transmitted by the image guide 33 of the fiberscope 29 on the imaging surface of the imaging device 34.

The imaging lens 25 and the image sensor 34
Between them, a laser light cut filter 36 is provided. The laser light cut filter 36 is rotatably held by a center shaft 37.

The laser light cut filter 36
Is described by a guide rail 38 for its rotation. The external camera 31 has a laser light cut filter 3
An adjustment knob 39 for controlling the rotation of 6 is further provided.

By adjusting the adjustment knob 39 by a user, the laser light cut filter 36 can be rotated to a desired angle. By using the external camera 31 configured as described above, even if the fiberscope 29 is used, the same function as the photodynamic therapy device of the first embodiment can be provided.

Further, the external camera 3 of the first modification is
If 1, the existing fiberscope can be used, so that the photodynamic therapy device 28 can be provided at relatively low cost.

In the first modification, the rotation of the laser beam cut filter 36 is described as being adjusted by the adjustment knob 39. However, similar to the first embodiment, the filter drive constituted by the actuator is performed. Using means,
The rotation angle of the laser light cut filter 36 may be automatically controlled.

In the first modification shown in FIG. 4, it has been described that an existing fiberscope can be used. However, not only the existing fiberscope but also an existing external camera can be used. A mechanical treatment device can also be configured. An example thereof will be described as a second modified example with reference to FIG.

The photodynamic therapy device 40 of the second modification example
Has a fiberscope 29, an external camera 41, and an adapter 42 for connecting these.

The external camera 41 is an existing external camera, and has an image sensor 43 inside. The external camera 3 described in the first modified example of FIG.
1 is provided with a laser light cut filter 36, an adjustment knob 39, and the like.

The adapter 42 has an attachment / detachment mechanism 44 for detachably connecting to the external camera 41. By using the adapter 42 as shown in the second modification, the photodynamic therapy device 40 can be configured at lower cost with an existing fiberscope and an external camera.

The laser light generator 6 of the first embodiment has been described as generating laser light of a predetermined wavelength from the laser light source 22. On the other hand, another example of the laser light generator 6 is shown in FIG.
This will be described with reference to FIG.

FIG. 6 is a schematic diagram of a photodynamic therapy device 45 according to a third modification. The same members as those described in the first embodiment are denoted by the same reference numerals, and description thereof will be omitted.

The laser light generator 46 of the photodynamic therapy device 45 has a dye excitation laser 47 for exciting the dye. As the dye excitation laser 47, an argon laser, a KTP laser, or the like can be used.

The laser light emitted from the dye excitation laser 47 is split by the half mirror 48. The laser light reflected by the half mirror 48 is applied to the mirror 49.

The laser light transmitted through the half mirror 48 is
The laser light irradiated to the first dye 50 and reflected by the mirror 49 is irradiated to the second dye 51. First dye 50
The second dye 51 excites laser beams having different wavelengths from each other.

The laser light of the first wavelength excited by the first dye 50 is reflected by the mirror 52 to the half mirror 53. Further, the laser light of the second wavelength excited by the second dye 51 is applied to the half mirror 53.

The half mirror 53 combines the laser light of the first wavelength and the laser light of the second wavelength and makes the laser light incident on the light guide probe of the laser light probe 21. As a result, the laser light obtained by combining the laser light of the first wavelength and the laser light of the second wavelength can be emitted from the tip of the laser light probe 21.

FIG. 6 omits the description relating to the reception of the laser beam. The provision of the laser light generator 46 configured as described above enables the following photodynamic treatment.

In photodynamic therapy, two different types of photosensitizers (eg, ALA and THPC) are administered to the lesion depending on the characteristics of the tissue or photosensitizer. In such a case, it is usually necessary to perform photodynamic therapy using laser light having a wavelength suitable for each photosensitizer sequentially, and the treatment time at that time naturally becomes longer.

However, the laser light generator 4 shown in FIG.
6, laser light of two different wavelengths at the same time, ie, a first wavelength laser light suitable for exciting one of the photosensitive materials and a second wavelength laser light suitable for exciting the other photosensitive material Light can be generated at the same time, and this can be applied to the lesion.

Therefore, the photodynamic treatment time can be shortened, and there is no need to change the laser beam to be irradiated on the lesion to another laser beam. FIG. 7 shows another example of the laser light generator.

Laser Light Generator 5 as Fourth Modification
4 is provided with a YAG laser generator 55. The laser light generated from the YAG laser 55 is incident on the harmonic generation unit 56. The harmonic generator 56 has a function of converting the laser light generated from the YAG laser generator 55 into a third harmonic component.

The laser light converted into a higher harmonic wave by the higher harmonic wave generator 56 is reflected by the mirror 57 and is reflected by the half mirror 5.
8 and is divided. The laser light reflected by the half mirror 58 is applied to the mirror 59.

The laser light transmitted through the half mirror 58 is incident on the first OPO crystal 60 having a function of changing the wavelength, and the laser light reflected by the mirror 59 has the function of changing the wavelength. A second OPO having
The light is incident on the crystal 61.

The laser beam transmitted through the first OPO crystal 60 is reflected by the mirror 62 to the half mirror 63. The half mirror 63 is composed of the laser light transmitted through the second OPO crystal and the first OPO reflected by the mirror 62.
The laser light transmitted through the crystal is synthesized, and is incident on the end face of the light guide probe 19.

As described above, by configuring the laser light generator 54 using the first OPO crystal and the second OPO crystal,
The same effect as that of the laser light generator 46 of the third modification can be obtained.

[Appendix] (Appendix 1) Imaging means for taking an image of the subject, display means for displaying the subject image based on an output signal of the imaging means, and irradiating the subject with laser light. A photodynamic therapy apparatus having a laser beam irradiation unit, wherein the filter unit is held on the imaging surface side of the imaging unit so as to be tiltable at an arbitrary angle with respect to the optical axis, and the filter unit is disposed with respect to the optical axis. A photodynamic therapy device, comprising: filter driving means for inclining at a predetermined angle. (Additional Item 2) Imaging means for capturing an image of the subject, display means for displaying the subject image based on an output signal of the imaging means, and laser light irradiation means for irradiating the subject with laser light. A photodynamic therapy apparatus having a filter means held on the imaging surface side of the imaging means so as to be tiltable at an arbitrary angle with respect to the optical axis, and tilting the filter means at a predetermined angle with respect to the optical axis Filter driving means, laser light receiving means for receiving laser light reflected from the subject, filter control means for controlling the filter driving means based on the intensity of the laser light received by the laser light receiving means, A photodynamic therapy device comprising: (Additional Item 3) Imaging means for capturing an image of the subject, display means for displaying the subject image based on an output signal of the imaging means, and laser light irradiation means for irradiating the subject with laser light. A photodynamic therapy apparatus having a filter means held on the imaging surface side of the imaging means so as to be tiltable at an arbitrary angle with respect to the optical axis, and tilting the filter means at a predetermined angle with respect to the optical axis A filter driving unit, a laser light source unit that irradiates laser beams having different wavelengths to the laser beam irradiation unit, a laser beam receiving unit that receives a laser beam reflected from the subject, and a laser beam that is received by the laser beam receiving unit. Filter control means for controlling the filter driving means based on the intensity of the laser light, and output from the laser light source means based on the intensity of the laser light received by the laser light receiving means. Photodynamic therapy apparatus and the wavelength controlling means for changing the wavelength of the laser beam, characterized by comprising the to that. (Additional Item 4) Imaging means for capturing an image of the subject, display means for displaying the subject image based on an output signal of the imaging means, and laser light irradiation means for irradiating the subject with laser light. A photodynamic therapy apparatus having a filter means held on the imaging surface side of the imaging means so as to be tiltable at an arbitrary angle with respect to the optical axis, and tilting the filter means at a predetermined angle with respect to the optical axis Filter driving means, laser light source means capable of entering laser light having a different wavelength into the laser light irradiation means, and means for changing the wavelength of laser light output from the laser light source means with time,
Laser light receiving means for receiving laser light of a wavelength that changes with time reflected from the subject; and laser light output by the laser light source means based on the intensity of the laser light received by the laser light receiving means. A photodynamic therapy apparatus comprising: means for determining a wavelength; and filter control means for controlling the filter driving means according to the wavelength of the laser light output from the laser light source means. (Additional Item 5) The photodynamic therapy apparatus according to the additional items 1 to 4, wherein the imaging means is provided with an electronic endoscope. (Additional Item 6) The photodynamic therapy apparatus according to the additional items 1 to 4, wherein the imaging means is provided with an external camera attached to an eyepiece of a fiberscope. I do. (Additional Item 7) The photodynamic therapy apparatus according to the additional items 1 to 4, wherein the filter means is composed of an interference filter or a holographic notch filter. (Additional Item 8) Imaging means for capturing an image of the subject, display means for displaying the subject image based on an output signal of the imaging means, and laser light irradiating means for irradiating the subject with laser light. An adapter for a photodynamic therapy device used in a photodynamic therapy device having the image sensor, the adapter being detachably connected to the imaging means, and being capable of being inclined at an arbitrary angle with respect to an optical axis on an imaging surface side of the imaging means. An adapter for a photodynamic therapy device, comprising: a filter unit formed of an interference filter held by the filter unit; and a filter driving unit for tilting the filter unit at a predetermined angle with respect to an optical axis. (Additional Item 9) A first laser light generating means for generating a laser light of a first wavelength, a second laser light generating means for generating a laser light of a second wavelength different from the first wavelength, Beam dynamics comprising means for simultaneously entering the first laser light generated by the first laser light generating means and the second laser light generated by the second laser light generating means on the same optical path. Light source device for medical treatment equipment.

[0094]

According to the present invention, there are provided imaging means for capturing an image of a subject, display means for displaying the subject image based on an output signal of the imaging means, and laser light for irradiating the subject with laser light. A photodynamic therapy device having an irradiating means, a filter means comprising an interference filter held on the imaging surface side of the imaging means so as to be tiltable at an arbitrary angle with respect to the optical axis; and Filter driving means for tilting the filter at a predetermined angle with respect to the filter driving means.

In other words, the filter driving means can incline the filter means composed of the interference filter at a predetermined angle, so that the wavelength of the light imaged on the image pickup means can be restricted while being adjusted. .

Therefore, even if the wavelength of the therapeutic laser beam is changed in order to enhance the effect of the photodynamic therapy, the inclination of the filter is changed in accordance with the change, so that the therapeutic laser beam is captured by the imaging means. Good photodynamic treatment can be performed without adverse effects.

[Brief description of the drawings]

FIG. 1 is a diagram showing an overall configuration of a photodynamic therapy device according to a first embodiment of the present invention.

FIG. 2 is a cross-sectional view of the distal end of the insertion portion of the electronic endoscope of the photodynamic therapy device.

FIG. 3 is a characteristic diagram showing light transmission characteristics of a laser light cut filter provided at the tip of the electronic endoscope.

FIG. 4 is a cross-sectional view of an external camera of a photodynamic device according to a first modification;

FIG. 5 is a sectional view of an adapter of a photodynamic device according to a second modification.

FIG. 6 is a diagram showing an overall configuration of a photodynamic device according to a third modification.

FIG. 7 is a block diagram of a laser light generator of a photodynamic device according to a fourth modification.

[Explanation of symbols]

 1, 28, 40 Photodynamic therapy device 2 Electronic endoscope 3 Light source device 4 Video processor 5 Display device 6, 46, 54 Laser light generation device 7 Light guide fiber 8 Insertion section 9 Illumination lens 11 Objective lens 12, 34, 43 imaging device 13, 36 laser light cut filter 15 filter driving means 16 filter control unit 18 treatment tool insertion port 19 light guide probe 20 light receiving probe 21 laser light probe 22 laser light source 23 laser light detection sensor 24 wavelength control unit 25 wavelength determination unit 26, 37 Central axis 27, 38 Guide rail 31 External camera 35 Imaging lens 39 Adjustment knob 42 Adapter

Claims (1)

[Claims] An imaging unit configured to capture an image of a subject; a display unit configured to display the subject image based on an output signal of the imaging unit; and a laser light irradiation unit configured to irradiate the subject with laser light. A photodynamic therapy apparatus having: a filter unit held on the imaging surface side of the imaging unit so as to be tiltable at an arbitrary angle with respect to an optical axis; and the filter unit is tilted at a predetermined angle with respect to the optical axis. A photodynamic therapy device, comprising: filter driving means.