JPH1192327A - Composition giving refreshed feeling - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition expressing a less irritating feeling, and useful as a cosmetic material and a dermal medicine for external use by containing monomenthly glyceryl ether, camphor, etc. SOLUTION: The composition giving refreshed feeling is obtained by containing (A) monomenthyl glyceryl ether and (B)(i) camphor and/or (ii) menthol in preferably 30-70 wt.% component (A) based on the total amount and (0.1-0.5:1) weight ratio of (B)(i) to (B)(ii). The composition is useful as a cosmetic material such as a cream, a cosmetic lotion, a milky lotion, etc., and a dermal medicine for external use such as an antifungal external agent, an anti-inflammatory external agent, a sterilizing and bactericidal external agent, etc. The content of the composition in the above products is preferably 0.01-10 wt.% as the composition and <=2 wt.% as the component (B) based on the total of components being a liquid or a solid at 25 deg.C under 1 atm, of the product.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cooling composition suitable for cosmetics, external medicines for skin and the like.

[0002]

2. Description of the Related Art In skin preparations such as cosmetics and external preparations for skin, the refreshing sensation at the time of use is very important. For example, in pharmaceuticals and the like, many skin external preparations containing an anti-inflammatory analgesic component as an active ingredient are commercially available,
Such preparations cause inflammation and are often applied to areas with elevated skin temperature, are expected to provide a refreshing feeling and relieve the pain of inflammation, and cosmetics applied to skin such as sunburn Is expected to have an effect of cooling a hot flash by a cooling component. In order to meet such expectations, cooling ingredients such as menthol and camphor are mainly blended. However, these conventionally used cooling components have a narrow threshold of refreshing feeling and irritation, and sometimes develop resources at a concentration that develops a refreshing feeling. . Furthermore, since menthol has a percutaneous absorption promoting effect, if its amount is excessively increased, it may be percutaneously absorbed to an undesired level, such as a preservative, causing an undesired skin reaction. I was concerned. Furthermore, there was a concern that sustainability would be lost due to promotion of transdermal absorption of the medicinal ingredient. Monomenthyl glyceryl ether is a cooling agent developed for foods as an odorless menthol. It expresses a refreshing sensation when absorbed in mucous membranes such as the oral cavity. Was extremely weak and could not be compared to menthol or camphor. That is, in a skin external preparation, a refreshing component having a low sensation of irritation has been required.

[0003] On the other hand, it has never been known to combine monomenthyl glyceryl ether with camphor and / or menthol, and such a combination provides a refreshing composition having a sufficient refreshing feeling and an extremely low irritation. Was also not known at all.

[0004]

SUMMARY OF THE INVENTION The present invention has been made in view of such circumstances, and it is an object of the present invention to provide a refreshing component which does not exhibit a stimulating feeling.

[0005]

Means for Solving the Problems In view of such a situation, the inventors of the present invention have conducted intensive studies for a refreshing component having less sensation of irritation, and as a result, have found that monomenthyl glyceryl ether and camphor and / or menthol can be used. Such effects were found in the combined cooling composition, and the invention was completed. Hereinafter, the present invention will be described in detail focusing on embodiments.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION

(1) Cooling composition of the present invention The cooling composition of the present invention comprises monomenthyl glyceryl ether and camphor and / or menthol. In the cooling composition of the present invention, the proportion of monomenthyl glyceryl ether in the total amount of the cooling composition is preferably 20 to 80% by weight, more preferably 25 to 75% by weight, further preferably 30 to 70% by weight. preferable. or,
Either one of camphor and menthol can be used, or a combination of the two can be used. It is preferable to use the two in combination, and as a mixing ratio, when the weight ratio of menthol is 1, the weight ratio of camphor is 0.01 to 1, more preferably 0.05 to 0. 7, more preferably 0.1 to
It is better to set it to 0.5. These substances, which are components of the cooling composition of the present invention, are already commercially available and easily available. The cooling composition of the present invention contains monomenthyl glyceryl ether to reduce the irritancy possessed by camphor or menthol, and is used in combination with camphor and / or menthol to the same degree as when camphor or menthol is used alone. Characterized by having a cool feeling. The cooling composition of the present invention can be used as a substitute for camphor or menthol in products in which camphor or menthol has been used conventionally. Examples of such products include foods and cosmetics Examples include cosmetics, oral cleansers, cleansing agents, bath preparations, and external dermatological agents. Among them, they are suitably used for cosmetics and external dermatological agents, and particularly preferably for cosmetics. This is because the cooling composition of the present invention is excellent in safety,
This is because the effect can be more exhibited in a product that is assumed to be used for a long period of time or a product that is expected to be used on damaged skin. In these products, the content of the cooling composition of the present invention is as follows.
With respect to the total weight of the components that are liquid or solid
It is preferably from 0.01 to 10% by weight, more preferably from 0.05 to 7% by weight, and still more preferably from 0.1 to 5% by weight. Further, the ratio of the sum of the weights of menthol and camphor in the cooling composition of the present invention is not more than 2% by weight based on the total weight of the components which are liquid or solid at 25 ° C under 1 atm in the product;
It is more preferably 1.7% by weight or less, and still more preferably 1.
It is particularly preferred that the content be 5% by weight or less. Here, the meaning of the sum of the weights of the components that are liquid or solid at 25 ° C. under 1 atm is converted to the total composition of the product because aerosol products and the like are included in the product. This is to remove volatile components such as gas components which have no relation to the effect in the case of the above.

(2) External preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing the above cooling composition. The external preparation for skin referred to in the present invention is a composition in a form to be applied on the skin and is premised on being stored on the skin for a long time, and specific examples include creams, lotions, and emulsions. And cosmetics such as foundations, antiperspirants, packs, and hair tonics; and external skin medicines such as antifungal external preparations, anti-inflammatory external preparations, analgesic external preparations, and external preparations for disinfection and sterilization. Among them, cosmetics are particularly preferred, because the cooling composition of the present invention is excellent in safety. The external preparation for skin of the present invention can contain, in addition to the above-mentioned refreshing composition, which is an essential component, any optional component usually used in external preparations for skin. Examples of such optional components include hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, and stearic acid. Fatty acids such as oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, ethanol, carbopol, etc. Viscous agents, preservatives, ultraviolet absorbers, antioxidants, pigments, powders, anti-inflammatory agents, antifungal agents, analgesics, disinfectants, bactericides, wound healing agents, wound protectants, gas for ejection, etc. Can be illustrated. The form can be used without any particular limitation as long as it is a form usually used in external preparations for the skin, such as a solution, an emulsion such as an emulsion or a cream, or an aerosol in which these are ejected with a gas. Further, the cooling composition of the present invention exerts its effect more effectively in the presence of a nonionic surfactant, and is therefore preferably used as a product containing the nonionic surfactant. Preferred nonionic surfactants include polyoxyethylene fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene hardened castor oil, polyoxyethylene sorbitan fatty acid ester, and the like, and HLB is preferably 10 to 20.

[0008]

The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited to these examples.

<Examples 1 to 4> Cooling compositions were prepared according to the formulations shown in Table 1 below. That is, the prescription component is 80 ° C.
To obtain a cooling composition.
In addition, Comparative Examples 1 to 3 alone were prepared in the same manner, and their irritation was examined with a guinea pig closed patch of damaged skin.
That is, after shaving the back of a group of five Hartley white male guinea pigs, each was stripped four times with a gum tape, and a 0.1% by weight ethanol solution of the above cooling composition was closed-patched for 24 hours. The skin reaction was observed according to the criteria of. The results are shown in Table 2 as the number of examples. From this table, it can be seen that the cooling composition of the present invention has high safety, especially, high safety against damaged skin. (Draise criteria) ++: reaction with edema +: reaction with clear erythema ±: reaction with indistinct erythema-: no reaction

[0010]

[Table 1]

[0011]

[Table 2]

<Examples 5 to 7> The antiperspirant cosmetics of the present invention were prepared according to the following formulations. That is, the component (a) was mixed with a Henschel mixer, and then pulverized with a pulverizer equipped with a round hole screen having a diameter of 0.7 mm. This was dispersed in a homogeneously solubilized component (b), 7 parts by weight of this dispersion was packed in an aerosol can, and 93 parts by weight of liquefied natural gas was charged to obtain a cosmetic. The composition of the nonvolatile components is also shown. (Prescription) A Hollow polyacrylate 0.4 parts by weight Nylon powder 12.6 parts by weight b Isopropyl myristate 8 parts by weight Cooling composition in Table 3 1 part by weight Allantoinchlorohydroxyaluminum 1 part by weight Ethanol 75 parts by weight ( Composition of non-volatile component) Hollow polyacrylate 1.7% by weight Nylon powder 54.8% by weight Isopropyl myristate 34.8% by weight 4.3% by weight of cooling composition in Table 3

[0013]

[Table 3]

Example 8 Examples 5 to 7 and Comparative Example 4
For the cosmetics of Nos. To 6, a person with atopic dermatitis was subjected to a use test as a panel, and the irritation was examined by a questionnaire. The panelists prepared seven groups of five persons per group, the samples of Examples 5 to 7 and Comparative Examples 4 to 6 were prepared for groups 1 to 6, and the cooling composition was replaced with ethanol for group 7 (control product). Was used for one week. The irritability was evaluated on a three-point scale: irritability, slight stimulus, and no stimulus. Table 4 shows the results as examples. This indicates that the cosmetic of the present invention has low irritation and can be used safely by a person with atopic dermatitis. Furthermore, at the same time, the refreshing feeling and the sweat-reducing effect of the cosmetics were examined by a questionnaire. In the evaluation, ++: very excellent, +: excellent, somewhat unsatisfactory, unsatisfactory, were given a score. The results are shown in Table 5 as the number of appearance cases. This indicates that the refreshing composition of the present invention is excellent in refreshing feeling and sweat suppressing effect.

[0015]

[Table 4]

Example 9 An antiperspirant powder was prepared according to the following formulation. That is, A was mixed with a Henschel mixer, pulverized with a pulverizer equipped with a round hole screen having a diameter of 0.7 mm, returned to the Henschel mixer, and coated with B while stirring. This was pulverized with a pulverizer equipped with a 1 mm herringbone screen, packed in a gold plate and pressed to obtain an antiperspirant powder. I had this thing used by people with severe tanning due to sunburn,
No irritation was observed. It can be seen that the cosmetic of the present invention has low irritation. A Allantinchlorohydroxyaluminum 0.1 parts by weight Hollow polyacrylate 1 part by weight Talc 78.9 parts by weight Menthol 0.1 parts by weight Camphor 0.1 parts by weight Monomenthyl glyceryl ether 1 part by weight Smoke-like silica gel 8.8 parts by weight Part rosimethicone 10 parts by weight

Example 10 According to the following formulation,
An antifungal skin external pharmaceutical composition was prepared. That is, the formulation components were heated and solubilized at 80 ° C. to obtain a skin external preparation. About this thing and the comparative example shown below, severe athlete's foot patient 10
Used for names and compared. Table 5 shows the results. It can be seen that the external preparation for skin of the present invention can be used safely and with little pain, even for severe athlete's foot patients with vilan on the skin. (Pharmaceutical composition of the present invention) 1% by weight of bifonazole hydrochloride 1% by weight of monomenthyl glyceryl ether 0.1% by weight of menthol 0.1% by weight of camphor 97.8% by weight of ethanol (Comparative Example 7) 1% by weight of bifonazole hydrochloride 1% by weight of menthol 0 0.1 wt% ethanol 98.9 wt% (Comparative Example 8) bifonazole hydrochloride 1 wt% monomenthyl glyceryl ether 1 wt% ethanol 98 wt% (Comparative Example 9) bifonazole hydrochloride 1 wt% camphor 0.1 wt% ethanol 98. 9% by weight

[0018]

[Table 5]

[0019]

According to the present invention, it is possible to provide a refreshing ingredient with less stimulating feeling.

Claims (11)

[Claims] 1. A cooling composition comprising monomenthyl glyceryl ether and camphor and / or menthol. 2. The cooling composition according to claim 1, wherein the weight ratio of menthol and / or camphor to monomenthyl glyceryl ether is 1 or less. 3. The cooling composition according to claim 1, comprising monomenthyl glyceryl ether and camphor. 4. An external preparation for skin, comprising the cooling composition according to any one of claims 1 to 3. 5. The external preparation for skin according to claim 4, which is a cosmetic. 6. An external preparation for skin at 25 ° C. under 1 atm.
The skin external preparation according to claim 4 or 5, wherein the ratio of the sum of the weights of menthol and camphor to the sum of the weights of the components that are liquid or solid is 2% by weight or less. 7. The external preparation for skin according to any one of claims 4 to 6, which is an aerosol product. 8. An external preparation for skin containing monomenthyl glyceryl ether and camphor and / or menthol. 9. The external preparation for skin according to claim 8, which is a cosmetic. 10. An external preparation for the skin, under 1 atm, 25
10. The external preparation for skin according to claim 8 or 9, wherein the ratio of the sum of the weights of menthol and camphor to the sum of the weights of the components that are liquid or solid at C is 2% by weight or less. 11. The external preparation for skin according to any one of claims 8 to 10, which is an aerosol product.