JP2002053452A - Stress-corresponding cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a means for preventing or improving reduction of skin barrier potency by stress. SOLUTION: This stress-corresponding cosmetic contains (1) 1,2-pentanediol and (2) one or more species selected from a polyethylene glycol having 200-1000 average molecular weight, dipropylene glycol, glycerol, diglycerol, a polyoxyalkylenemethyl glycoside, sorbitol and maltitol.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin which is useful for improving a decrease in barrier function caused by stress.

[0002]

2. Description of the Related Art The modern age is said to be an age of excessive stress, and such an excessively applied stress causes various physical problems to the human body. Such a disease or physical condition peculiar to modern times includes a rapid increase in dry skin. According to a study by the present inventors, the percentage of people who have dry skin recognition was 13% ten years ago, but has increased to about 27% in modern times. In such dry skin, the barrier function of the skin deteriorates, so it is easy to become sensitive skin.In fact, the number of people who actually recognize the sensitive skin is increasing, and the positive rate for standard substances in patch tests etc. is also increasing. ing. Dealing with people with such dry skin is a major challenge in modern times. Dry skin caused by such stress,
The barrier function of the skin is reduced due to the application of stress, and the conventional moisturizing component often does not work effectively on such dry skin. In other words, although a means for treating the reduced barrier function due to such stress and treating the dry skin caused by the decrease has been desired, it has not been obtained at present.

On the other hand, in external preparations for skin, 1) 1,2-
Skin containing pentanediol and 2) one or more selected from polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, diglycerin, polyoxyalkylenemethylglucoside, sorbitol and maltitol having an average molecular weight of 200 to 1000 No external preparations are known, and thus it has never been known that such a skin external preparation is useful for treating a barrier function that is reduced by stress and caused by dry skin.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, and it is an object of the present invention to provide a means for reducing the barrier function due to stress and treating dry skin caused thereby. I do.

[0005]

In view of such circumstances, the present inventors have sought to find a means for treating the barrier function caused by the decrease in the barrier function due to stress and the dry skin caused by the stress. 1) selected from 1) 1,2-pentanediol and 2) polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, diglycerin, polyoxyalkylenemethyl glucoside, sorbitol and maltitol having an average molecular weight of 200 to 1000.
Such effects have been found in a skin external preparation containing one or more kinds, and the present invention has been completed. That is, the present invention relates to the following technology. (1) 1) 1,2-pentanediol and 2) polyethylene glycol, propylene glycol, dipropylene glycol, glycerin having an average molecular weight of 200 to 1,000,
An external preparation for skin, comprising one or more selected from diglycerin, polyoxyalkylenemethylglucoside, sorbitol and maltitol. (2) 1) 1,2-pentanediol and 2) polyethylene glycol, propylene glycol, dipropylene glycol, glycerin having an average molecular weight of 200 to 1,000,
(1) a weight ratio of the content of one or more selected from diglycerin, polyoxyalkylenemethylglucoside, sorbitol and maltitol to 3: 1 to 1: 1; 2. The external preparation for skin according to item 1. (3) The external preparation for skin according to (1) or (2), which is a cosmetic. (4) It is characterized by being used for stress. (1)
To (3) The external preparation for skin according to any one of the above. (5) The external preparation for skin according to any one of (1) to (4), further comprising a methylsiloxane network polymer and / or a cross-linked methylpolysiloxane. Hereinafter, the present invention will be described in more detail focusing on embodiments.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS (1) 1,2-Pentanediol which is an essential component of the external preparation for skin of the present invention is characterized by containing 1,2-pentanediol. 1,2-Pentanediol is a polyhydric alcohol that has already been used as a humectant in cosmetics, and cosmetic grades are commercially available, so that it is very easy to obtain. In the external preparation for skin of the present invention, together with the polyhydric alcohol group to be described later, the conventional moisturizing component and the known combination thereof could not sufficiently cope with the stress, especially due to excessive stress load. It has the effect of improving the dryness that occurs and preventing such undesirable factors from affecting the skin. In order to exhibit such an effect, it is necessary that the content of 1,2-pentanediol in the cosmetic is preferably 0.1 to 20% by weight, more preferably 1 to 10% by weight. . The preferred weight ratio of the 1,2-pentanediol to one or two or more selected from the polyhydric alcohol group described below is 3: 1 to 1: 1 and more preferably. Is 3: 1
2: 1. This is because a favorable treatment is possible in such an amount range.

(2) Polyhydric alcohols which are essential components of the external preparation for skin of the present invention The external preparation for skin of the present invention comprises one or more selected from the following polyhydric alcohols as an essential component. As a feature. That is, such polyhydric alcohols are polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, diglycerin, polyoxyalkylenemethyl glucoside, sorbitol and maltitol having an average molecular weight of 200 to 1,000. Of these, preferred examples of polyoxyalkylene methyl glucoside include polyoxypropylene methyl glucoside and polyoxyethylene methyl glucoside. These commercial products include glycopolyol PP25
(Nippon Oil & Fats Co., Ltd.) and Glucam E-10 (Amacor Co., Ltd.) are cosmetic raw materials and can be preferably exemplified. Other raw materials are all raw materials for cosmetics, and are usually used in external preparations for skin. Further, all of these polyhydric alcohols are commercially available, and can be easily obtained. These can be used alone or in combination of two or more. Of these, particularly preferred are dipropylene glycol and diglycerin. This is because the combination effect with these is high. In the present invention, the content of these polyhydric alcohols is preferably 0.03 to 20% by weight, more preferably 0.3 to 10% by weight, based on the total amount of the external preparation for skin. . This is due to the reason shown in (1).

(3) External preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing the above essential components. The external preparation for skin of the present invention, by the effect of the above components,
Conventional cosmetics and external medicine for skin could not respond,
It has a remarkable effect on dry skin caused by a decrease in skin barrier function caused by stress and the like. The external preparation for skin of the present invention can be used without any particular limitation as long as it is of a type applicable to people with such dry skin, for example, creams, milky lotions, lotions, foundations, and under makeup. And the like, cosmetics for external use on the skin, germicidal disinfectants for external use on skin, sundry goods for external use, and the like. Particularly preferred among these are cosmetics and skin external medicines, and more preferably cosmetics. this is,
This is because of the attributes that are commonly used and those that require a particularly significant effect. The external preparation for skin of the present invention may contain optional components usually used in such external preparation for skin in addition to the above essential components. Such optional components include, for example, esters such as carnauba wax, octyldodecyl oleate, silicones such as dimethicone, femethicone, and ammedicone, triglycerides such as olive oil, tallow, coconut oil, stearic acid, oleic acid, Fatty acids such as ritinoleic acid, higher alcohols such as oleyl alcohol, stearyl alcohol, and octyl dodecanol; polyhydric alcohols such as polyethylene glycol, glycerin and 1,3-butanediol; thickening / gelling agents; antioxidants; Examples include an absorbent, a coloring agent, a preservative, a powder, and an active ingredient. Preferred examples of the active ingredient in the external medicine for skin include steroids, nonsteroidal anti-inflammatory drugs, vitamins and the like. These contents may be in accordance with the doses which have already been determined, but are generally about 0.1 to 10% by weight in view of the range in which the effects are exhibited. Among these optional components, preferred components for the whole skin external preparation are solid silicones, such as a methylsiloxane network polymer and / or a cross-linked methylpolysiloxane, which can physically supplement the barrier function. . They also have the secondary effect of reducing the physical stimulus during application by lowering the coefficient of friction during spreading. The preferred content of these solid silicones is from 0.1 to 20% by weight, more preferably from 2 to 8% by weight, based on the total amount of the cosmetic. This is because, if the amount is too small, the barrier complementing function may not be obtained, and if the amount is too large, the effect reaches a plateau, and the degree of freedom of prescription and the usability may be impaired. The external preparation for skin of the present invention can be produced by treating these essential components and optional components according to a conventional method.

[0009]

The present invention will now be described with reference to examples.
Although described in more detail, it goes without saying that the present invention is not limited to only these examples.

<Example 1> A cosmetic of the present invention was prepared according to the following formulation. That is, the ingredients were stirred and solubilized to obtain a lotion as the cosmetic of the present invention. Comparative Example 1 was obtained by replacing dipropylene glycol with 1,2-pentanediol, Comparative Example 2 was obtained by replacing 1,2-pentanediol with dipropylene glycol, and was obtained by replacing dipropylene glycol with glycerin. Comparative Example 3, Comparative Example 4 in which 1,2-pentanediol was substituted with glycerin, Comparative Example 5 in which 1,2-pentanediol and dipropylenelenglycol were substituted with glycerin, and samples of these comparative examples. Was created similarly. This was evaluated using a stress-loaded dry skin model. That is, a group of five hairless mice was formed, and the amount of water dissipated in the back was measured.
The animals were bred for one week under the breeding conditions, and 24 hours after the breeding was completed, 0.01 ml of the sample was applied to the back, and 24 hours after the application.
At the time, the amount of water dissipated was measured again. In the control example, overcrowding was carried out, and no sample administration was performed. Table 1 shows the results. This shows that it is only the cosmetic of the present invention that effectively prevents moisture from being dissipated from the skin having a reduced barrier ability due to stress. 1,2-pentanediol 6 parts by weight Dipropylene glycol 3 parts by weight Phenoxyethanol 0.2 parts by weight Ethanol 5 parts by weight Methylsiloxane network polymer 1 part by weight ("Tospearl 120A") Water 84.8 parts by weight

[0011]

[Table 1]

<Examples 2 to 7> The same study as in Example 1 was conducted except that the polyhydric alcohol used in combination with 1,2-pentanediol was changed. Table 2 shows the results. This indicates that the polyhydric alcohols listed as essential components of the present invention all have an excellent barrier complementing function when the skin becomes rough due to stress. 1,2-pentanediol 6 parts by weight Polyhydric alcohol * 3 parts by weight Phenoxyethanol 0.2 parts by weight Ethanol 5 parts by weight Methylsiloxane network polymer 1 part by weight ("Tospearl 120A") Water 84.8 parts by weight * Details in the table It is shown in FIG.

[0013]

[Table 2]

Example 8 An under-makeup cosmetic, which is a cosmetic of the present invention, was prepared according to the following formulation. That is, the components (a), (b) and (c) are each heated to 70 ° C., (b) is neutralized by adding (b) to the mixture, and the mixture is emulsified by gradually adding (c) while stirring, homogenizing the particles by homogenizer treatment, stirring and cooling. Then, an under makeup cosmetic was created. Using this, a use test was performed on four people with poor foundation. As a comparative product, dipropylene glycol was completely substituted with 1,2-pentanediol (Comparative Example 6), the right half face was treated with the under make-up of the present invention, and the left half face was treated with Comparative Example 7,
I put the foundation that I usually use.
The evaluation was performed by a specialized panelist. As a result, it was presumed that the right half face had better adhesion, and that poor makeup riding was caused by potential stress and light damage. B Acrylic acid / alkyl methacrylate 0.6 parts by weight 1,2-pentanediol 3 parts by weight Dipropylene glycol 1 part by weight Glucam E-10 1 part by weight Ethanol 6 parts by weight Phenoxyethanol 0.2 parts by weight Water 50 parts by weight B 10 % Potassium hydroxide aqueous solution 1.5 parts by weight Water 25.7 parts by weight Hacetanol 3 parts by weight Hydrogenated tallow 2 parts by weight Microcrystalline wax 5 parts by weight Methylsiloxane network polymer 0.5 parts by weight Cross-linked methylpolysiloxane 5 parts by weight

Example 11 According to the following formulation,
A foundation, which is a cosmetic of the present invention, was prepared.
That is, the ingredients were kneaded, packed in a metal plate, and heated and pressed to obtain a foundation. This product was able to make up very well even for people with poor makeup. Microcrystalline wax 5 parts by weight Mokuro 5 parts by weight Carnauba wax 2 parts by weight Sorbitan sesquiolate 1 part by weight Castor oil 20 parts by weight 1,2-pentanediol 1.5 parts by weight Diglycerin 1 part by weight Glucopolyol PP25 0.5 parts by weight Sericite 15 parts by weight Mica 10 parts by weight Talc 10 parts by weight Titanium dioxide 20 parts by weight Iron oxide 5 parts by weight Methylsiloxane network polymer 4 parts by weight

[0016]

According to the present invention, it is possible to provide a means for preventing or improving a decrease in skin barrier ability due to stress.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 31/765 A61K 31/765 31/77 31/77 31/80 31/80 A61P 17/00 A61P 17 / 00 17/16 17/16 F term (reference) 4C083 AA082 AA122 AB032 AB232 AB242 AB432 AC012 AC072 AC102 AC121 AC122 AC172 AC432 AC441 AC442 AD041 AD042 AD092 AD151 AD152 AD171 AD172 BB51 CC03 CC12 EE12 4C086 AA01 AA02 FA02 FA05 MA01 MA02 MA04 MA04 MA04 ZB21 4C206 AA01 AA02 CA05 MA01 MA02 MA04 MA83 NA14 ZA89 ZB21

Claims (5)

[Claims] 1) 1) 1,2-pentanediol and 2) polyethylene glycol having an average molecular weight of 200 to 1000,
An external preparation for skin, comprising one or more selected from propylene glycol, dipropylene glycol, glycerin, diglycerin, polyoxyalkylenemethylglucoside, sorbitol and maltitol. 2. 1) 1,2-pentanediol and 2) polyethylene glycol having an average molecular weight of 200 to 1000,
The weight ratio of the content of one or more selected from propylene glycol, dipropylene glycol, glycerin, diglycerin, polyoxyalkylenemethyl glucoside, sorbitol and maltitol is 3: 1 to 1
The external preparation for skin according to claim 1, wherein the ratio is 1: 1. 3. The external preparation for skin according to claim 1, which is a cosmetic. 4. The external preparation for skin according to any one of claims 1 to 3, which is used for treating stress. 5. The external preparation for skin according to claim 1, further comprising a methylsiloxane network polymer and / or a cross-linked methylpolysiloxane.