JP2003055185A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To develop a combination of protective film ingredients having high antiseptic power and protecting properties and excellent usability and to provide a skin care preparation comprising the combination. SOLUTION: This skin care preparation is obtained by including phenoxyethanol and one or more kinds selected from linoleamidopropyl PG- dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimoium chloride phosphate in a cosmetic. In the skin care preparation, the preferred content of the phenoxyethanol is 0.2-1 wt.% and the preferred content of the one or more kinds selected from the linoleamidopropyl PG-dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate is 0.01-10 wt.% expressed in terms of the total amount and based on the total amount of the skin care preparation.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation, and more particularly to a skin external preparation suitable for cosmetics.

[0002]

2. Description of the Related Art In the field of external preparations for skin such as cosmetics and external medicine for skin, one of the important factors is to form a protective film on the skin to prevent the dissipation of water from the skin, It is possible to prevent the invasion of stimulating factors from the skin into the skin. Mucopolysaccharides such as sodium hyaluronate and heparin-like substances are known as substances that form such a film, but these are on the formulation or in the physical properties until such a protective film effect is sufficiently exerted. It is difficult to include an amount in the external preparation for skin. That is, if too much of such a component is contained, the viscosity becomes remarkably high, the usability is impaired, and unacceptable stickiness is felt in the feel during use. Therefore, it has been desired to develop a protective film component having high protection property and excellent usability. Also, for people with sensitive skin, preservatives such as parabens are used for the purpose of improving stability against microorganisms, but since these sometimes cause irritation, they maintain stability against microorganisms. At the same time, a method of avoiding the inclusion of such parabens has been desired.

On the other hand, linoleamidopropyl PG-dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate are all phosphoric acid having a plurality of long-chain hydrophobic groups. It is a pseudophospholipid mixture having a diester or triester as a constituent, and is known as a raw material for cosmetics. It is also possible to combine phenoxyethanol with glycerin, 1,3-butanediol, isoprene glycol, diphenol. Propylene glycol, diglycerin or 1,2
-It has not been known at all to combine with a polyhydric alcohol such as pentanediol, and by including such a combination in a skin external preparation, sufficient stability against microorganisms can be obtained without the use of parabens. It has not been known at all that an external preparation for skin which can prevent the expression of irritation by and can form an excellent protective film can be obtained.

[0004]

The present invention has been made under such circumstances, and a combination of protective film components having a high antiseptic property and a high protective property and excellent in usability has been developed, and a skin external preparation containing the same has been developed. The challenge is to provide.

[0005]

In view of such circumstances, the inventors of the present invention have made diligent research efforts to develop a combination of protective film components having high protection properties and excellent usability, and to provide a skin external preparation containing the same. As a result of overlapping, one or more kinds selected from linoleamidopropyl PG-dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate and phenoxyethanol were selected. Containing, preferably find such properties in external preparations for skin such as cosmetics containing polyhydric alcohols,
The invention was completed. That is, the present invention relates to the techniques described below. (1) Phenoxyethanol and one or more selected from linolamidopropyl PG-dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate. An external preparation for skin, characterized by containing. (2) The external preparation for skin according to (1), which further contains a polyhydric alcohol. (3) The polyhydric alcohol includes one selected from 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol, (1) or ( The external preparation for skin according to 2). (4) The polyhydric alcohol is one or more selected from glycerin, 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol. The external preparation for skin according to any one of (1) to (3). (5) The skin according to any one of (1) to (4), which further contains a salt of carboxyvinyl polymer and / or a salt of (C10-30) alkyl acrylate / methacrylate. Topical agent. (6) The external preparation for skin according to any one of (1) to (5), which is for protecting the skin from an irritant. (7) Cosmetics, (1) to (6)
The external preparation for skin according to any one of items. (8) The cosmetic according to (7), which is for sensitive skin. Hereinafter, the present invention will be described in more detail with a focus on the embodiments.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION (1) Phenoxyethanol which is an essential component of the skin external preparation of the present invention The skin external preparation of the present invention is characterized by containing phenoxyethanol as an essential component. Phenoxyethanol, also known as ethylene glycol monophenyl ether, is used as a raw material for cosmetics that has antiseptic effects. Although it has the property that it can be safely used even by people who are sensitive to parabens, etc. I had to say that this is not enough. In the external preparation for skin of the present invention, one or more selected from linoleamidopropyl PG-dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate. Has excellent antiseptic activity when used in combination with two or more kinds. The content of phenoxyethanol in the external preparation for skin of the present invention is preferably 0.2 to 1% by weight.

(2) Linolenamidopropyl PG-dimonium chloride phosphate, which is an essential component of the present invention,
Sodium borage amidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate The skin external preparation of the present invention is linoleamidopropyl PG-
Another essential constituent is to contain one or more selected from dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate. To do. Here, one or more selected from linoleamidopropyl PG-dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate are all plural. It is a pseudophospholipid mixture containing the phosphoric acid diester or triester having a long-chain hydrophobic group as a constituent, and can be produced by the method described in JP-A-59-4478. In addition, some of these compounds are already on the market, and such compounds can be used. Such commercial products include, for example, commercially available from Unichema, phospholipid EFA as linoleamidopropyl PG-dimonium chloride phosphate and sodium borageamidopropyl PG-dimonium chloride phosphate as sodium borageamidopropyl PG-dimonium chloride phosphate.
Phospholipid GLA and stearamidopropyl PG
As the -dimonium chloride phosphate, phospholipid PTC can be preferably exemplified. These may contain only one kind, or may contain two or more kinds in combination. As the external preparation for skin of the present invention, one or two selected from linoleamidopropyl PG-dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate. It is particularly preferable to use such a commercially available product as the seed or more in terms of maintaining quality stability. In the external preparation for skin of the present invention, linoleamidopropyl PG-
The preferable content of one or two or more selected from dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate is the total amount, and a skin external preparation 0.01 to the total amount
It is preferably 10% by weight, more preferably 0.1 to 1% by weight. This is because if the amount is too small, the coating properties may become unfavorable, and if the amount is too large, the effect may reach the ceiling.

(3) Polyhydric alcohol which is a semi-essential component of the skin external preparation of the present invention The skin external preparation of the present invention is characterized by containing a polyhydric alcohol as a semi-essential component. In the present invention, the polyhydric alcohol is derived from another essential component, linoleamidopropyl PG-dimonium chloride phosphate, sodium borage amidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate. Together with one or more selected, it has an action of forming a film having adhesion, which does not allow a stimulating substance to pass therethrough. In the external preparation for skin of the present invention, a polyhydric alcohol usually used in external preparations for skin can be used, and for example, propylene glycol, 1,
3-butanediol, glycerin, polyethylene glycol, isoprene glycol, dipropylene glycol, diglycerin, maltitol, sorbitol, xylitol or 1,2-pentanediol can be preferably exemplified, and among these, 1,3-butanediol, A form containing one selected from isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol is preferable, and more preferably,
One or two selected from glycerin, 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol.
The form which is more than one kind can be illustrated. The total content of these polyhydric alcohols is 4 to the total amount of the skin external preparation.
It is preferably 15% by weight, more preferably 5 to
It is 10% by weight. Further, among such constitutions, a form in which 1,3-butanediol, 1,2-pentanediol or isoprene glycol is contained in an amount of 3 to 6% by weight based on the total amount of the external preparation for skin is particularly preferable.

(4) External preparation for skin of the present invention The external preparation for skin of the present invention comprises phenoxyethanol and linoleamidopropyl PG-dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate as described above. One or more selected from stearamidopropyl PG-dimonium chloride phosphate is contained as an essential component, and a polyhydric alcohol is contained as a semi-essential component. Here, in the present invention, the external preparation for skin means a general term for external preparations such as cosmetics, external medicine for skin, and bactericidal / disinfectant for external skin. The external preparation for skin of the present invention can be applied to any of these, but it is preferably applied to cosmetics due to its mild characteristics, and particularly preferably applied to cosmetics for sensitive skin. In the external preparation for skin of the present invention, in addition to the above essential components,
It may contain any of the components usually used in external preparations for skin. Examples of such optional components include hydrocarbons such as squalane, liquid paraffin, and solid paraffin, silicones that are not essential components such as dimethicone and femethicone, esters such as jojoba oil and gay wax, stearic acid and olein. Fatty acids such as acids,
Higher alcohols such as behenyl alcohol, cetanol, and oleyl alcohol, triglycerides such as beef tallow and olive oil, stearic acid monoglyceride, sorbitan sesquioleate, polyoxyethylene sorbitan monooleate, polyoxyethylene stearate and other nonionic surfactants, sodium Anionic surfactants such as dium lauryl stearate, cationic surfactants such as quaternary alkyl ammonium salts, powders such as crystalline cellulose,
Preferred are carboxyvinyl polymer salts, acrylic acid / methacrylic acid (C10-30) alkyl copolymer salts, polyacrylic acid salts, bentonite, thickeners such as xanthan gum and hydroxypropylcellulose, and active ingredients such as vitamins and glycyrrhizin. It can be illustrated.
Among these, particularly preferable components for the external preparation for skin of the present invention include salts of carboxyvinyl polymers and / or salts of (C10-30) alkyl acrylate / alkyl methacrylate. This is because these exert the action of strengthening the protective film. The salts of these carboxyvinyl copolymers and the salts of acrylic acid / alkyl methacrylate (C10-30) copolymers are already on the market, and carboxyvinyl copolymers and acrylic acid / alkyl methacrylate (C
10 to 30) It can be formed in the system by neutralizing the copolymer. Such salts can be applied without particular limitation as long as they are physiologically acceptable and form a gel. For example, alkali metal salts such as sodium salts and potassium salts, ammonium salts, triethanolamine and triethylamine salts. Preferred examples thereof include organic amine salts such as, and basic amino acid salts such as lysine salt and arginine salt. Although several types of these are commercially available due to their viscosity characteristics, they may be used alone or in combination of two or more. A preferred form is a form containing both of these two types. When the salt of carboxyvinyl copolymer and the salt of acrylic acid / alkyl methacrylate (C10-30) copolymer are contained, a preferable combination is as carboxyvinyl polymer: acrylic acid. -Alkyl methacrylate (C10
˜30) Copolymer = 99: 1 to 9: 1. In addition, the content is converted to the free form,
0.05 to 1% by weight based on the total amount of the skin external preparation,
More preferably, it is 0.1 to 0.5% by weight. This is because if the amount is too large, the durability of the makeup may be impaired and the duration of the protective film may be shortened, and if the amount is too small, the protective film strengthening effect may not be exhibited. 1 selected from linoleamidopropyl PG-dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate, which are essential components of the external preparation for skin of the present invention. Since one or more kinds of them also have an antibacterial action, it is preferable that the external preparation for skin of the present invention does not contain parabens such as methylparaben and butylparaben which may cause irritation on sensitive skin. . The external preparation for skin of the present invention has a sufficient antiseptic action without containing such an antiseptic. The external preparation for skin of the present invention can be produced by treating these essential components and optional components according to a conventional method.

[0010]

The present invention will be described in more detail below with reference to examples, but it goes without saying that the present invention is not limited to these examples.

<Examples 1 to 3> Lotions, which are external preparations for skin of the present invention, were prepared according to the following formulations. That is, the components a and b were heated at 80 ° C., the mixture b was gradually added to a and neutralized, and the mixture was stirred and cooled to obtain a lotion. At the same time, Comparative Example 1 was prepared by substituting the linoleamidopropyl PG-dimonium chloride phosphate of Example 1 with sodium hyaluronate, and Comparative Example 2 was substituted with phosphatidylethanolamine. Using these lotions, the backs of 1 group of 6 Hartley white guinea pigs were shaved, and 0.01 ml was applied to a 2 cm x 2 cm site that had been stripped twice with gum tape.
A patch bandage impregnated with 0.01 ml of a 1% sodium lauryl sulfate aqueous solution was applied, and a closed patch was applied for 24 hours. Draize the skin reaction 1 hour after removing the patch bandage (++; reaction with edema, +;
The reaction was performed with clear erythema, ±; reaction with unclear erythema, −; no reaction). As a control, a component obtained by substituting water for Component 1 in the following formulation components was used. The results are shown in Table 1. From this, it is clear that the lotion, which is the external preparation for skin of the present invention, suppresses the invasion of sodium lauryl sulfate, which is a stimulant, into the skin by the protective film. In addition, the antiseptic activity of these substances was examined by observing their growth by transplanting Bacillus subtilis, Staphylococcus aureus, and Escherichia coli to an agar plate medium mixed with 10% of these skin external preparations with platinum ears. ,
The degree of colonies was evaluated and confirmed with a score of 5 (overall) to 0 (none). The results are shown in Table 2. It can be seen that the external preparation for skin of the present invention has an excellent antiseptic effect. 1% aqueous solution of icarboxyvinyl polymer 6 parts by weight 1% aqueous solution of Carbopol 1382 5 parts by weight (acrylic acid / methacrylic acid (C10-30) alkyl) quince extract 0.1 parts by weight component 1 * 0.1 parts by weight ethanol 6 Parts by weight phenoxyethanol 0.3 parts by weight water 77 parts by weight potassium borohydride 10% aqueous solution 5.5 parts by weight * Details are shown in Table 1.

[0012]

[Table 1]

[0013]

[Table 2]

<Examples 4 to 9> In the same manner as in Examples 1 to 3, polyhydric alcohol was added and the same examination was conducted. The results are shown in Table 3.
Shown in. From this, as the polyhydric alcohol of the present invention,
It can be seen that the preferred form is one containing one selected from 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol. All of them had the same or better antiseptic properties as those of Examples 1 to 3 in the above antiseptic test. 1% aqueous solution of icarboxyvinyl polymer 6 parts by weight 1% aqueous solution of carbopol 1382 5 parts by weight (acrylic acid / methacrylic acid (C10-30) alkyl) quince extract 0.1 parts by weight linoleamidopropyl PG-dimonium chloride phosphate 0 1 part by weight Polyhydric alcohol ** 6 parts by weight Phenoxyethanol 0.3 parts by weight Water 77 parts by weight Potassium hydroxide 10% aqueous solution 5.5 parts by weight ** Details are shown in Table 3.

[0015]

[Table 3]

Example 10 A lotion was prepared according to the following formulation in the same manner as in the above example. The results of protective film evaluation of this product are ± 3 cases and -3 cases, and it is understood that it is preferable that salts of acrylic acid / alkyl methacrylate are also present. 1% aqueous solution of icarboxyvinyl polymer 11 parts by weight quince extract 0.1 parts by weight linoleamidopropyl PG-dimonium chloride phosphate 0.1 parts by weight isoprene glycol 6 parts by weight phenoxyethanol 0.3 parts by weight water 77 parts by weight potassium rohydroxide 10% aqueous solution 5.5 parts by weight

Example 11 A lotion was prepared according to the following formulation in the same manner as in the above example. The results of the protective film evaluation of this product are ± 3 cases and −3 cases, and it is understood that the presence of the salt of carboxyvinyl copolymer is more preferable. Acrylic acid / alkyl methacrylate 11 parts by weight quince extract 0.1 parts by weight linoleamidopropyl PG-dimonium chloride phosphate 0.1 parts by weight isoprene glycol 6 parts by weight phenoxyethanol 0.3 parts by weight water 77 parts by weight potassium rohydroxide 10 % Aqueous solution 5.5 parts by weight

<Example 12> According to the formulation shown below,
An under-makeup cosmetic, which is the external preparation for skin of the present invention, was produced. That is, the ingredients a, b, and c are heated at 80 ° C., and gradually added to a to emulsify, and then c is added and neutralized, and the particles are adjusted with a homogenizer, and then stirred and cooled. Then, I got under makeup cosmetics. Using this make-up cosmetics, for 14 people who easily feel irritation in the foundation, after treating the right half face with this undermake, apply the foundation and apply the foundation to the left half face without undermakeup. Was applied. I have you use it like this for a week,
We asked them to answer questions about the degree of appearance of the stimulus of the foundation, the right one being less likely to feel irritation, the left and right being less likely to feel left, and the left being less likely to feel irritation. The result is that all of the 14 people answered that the right side is less likely to feel irritation (it is less likely to feel irritation when using undermakeup), and is a protective film for undermakeup cosmetics, which is the external preparation for skin of the present invention. The effect as was confirmed. Isetanol 0.1 parts by weight Jojoba oil 0.5 parts by weight Hazelnut oil 0.1 parts by weight Olive oil 0.1 parts by weight Cetyl 2-ethylhexanoate 4 parts by weight Squalane 5 parts by weight Tocopherol 0.1 parts by weight Paraben 0.1 Parts by weight phenoxyethanol 0.1 parts by weight polyoxyethylene stearate 0.6 parts by weight glyceryl monostearate 3 parts by weight diglyceryl monooleate 0.5 parts by weight iris foil (red) 1 part by weight spherical acrylic resin powder 4 parts by weight Parts Methylsiloxane network polymer 2 parts by weight "Silicone 9028J" 12 parts by weight (high degree of polymerization dimethylpolysiloxane; manufactured by Shin-Etsu Chemical) Linolemidopropyl PG-Dimonium chloride phosphate 0.5 parts by weight Sodium borageamidopropyl PG- Dimonium chloride phosphate 0. Parts by weight rocarboxyvinyl polymer 1% aqueous solution 10 parts by weight "pemulene TR-1" 1% aqueous solution 1 part by weight (acrylic acid / methacrylic acid (C10-30) alkyl copolymer) quince extract 0.1 parts by weight 1,3 -Butanediol 6 parts by weight Isoprene glycol 2 parts by weight Water 51 parts by weight Phenoxyethanol 0.2 parts by weight Sodium hydroxide 10% aqueous solution 5.5 parts by weight

<Example 13> According to the following formulation,
A steroid agent (external skin drug), which is the external skin preparation of the present invention, was prepared. That is, each of the prescription ingredients a, b, and c was heated to 70 ° C., gradually added to a, emulsified, and c was gradually added to and neutralized to obtain a steroid agent. B Light liquid isoparaffin 5 parts by weight Cetanol 2 parts by weight Polyoxyethylene (20) cetyl ether 1 part by weight Linoleamidopropyl PG-dimonium chloride phosphate 0.2 parts by weight Sodium borageamidopropyl PG-dimonium chloride phosphate 0. 3 parts by weight beclomethasone 1 part by weight roisoprene glycol 3 parts by weight 1,2-pentanediol 4 parts by weight 1,3-butanediol 1 part by weight 1% carboxyvinyl polymer aqueous solution 5 parts by weight 1% pemulene TR-2 aqueous solution 20 parts by weight Water 35 parts by weight Phenoxyethanol 0.5 parts by weight C 10% aqueous potassium hydroxide solution 2 parts by weight Water 20 parts by weight

[0020]

EFFECTS OF THE INVENTION According to the present invention, a combination of protective film components having high antiseptic properties and high protective properties and excellent usability can be developed, and a skin external preparation containing the same can be provided.

Front page continued (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 47/10 A61K 47/10 47/24 47/24 47/32 47/32 A61P 17/16 A61P 17/16 F term (Reference) 4C076 AA17 BB31 CC04 CC18 DD30 DD34A DD37A DD38 DD39R DD63 EE09 EE12 EE23A EE48 4C083 AA112 AA122 AB032 AC022 AC072 AC102 AC111 AC112 AC121 AC122 AC171 AC172 AC57 AD02 AD021 AD1521 AD042 AD041 AD042 AD042 AD041 AD042 AD092 EE12

Claims (8)

[Claims] 1. One or more selected from 1) phenoxyethanol and 2) linoleamidopropyl PG-dimonium chloride phosphate, sodium borageamidopropyl PG-dimonium chloride phosphate and stearamidopropyl PG-dimonium chloride phosphate. Is an external preparation for skin, characterized by containing 2 or more kinds. 2. The external preparation for skin according to claim 1, further comprising a polyhydric alcohol. 3. The polyhydric alcohol comprises one selected from 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol. Or the external preparation for skin according to 2. 4. The polyhydric alcohol is glycerin, 1,3.
-One or more selected from butanediol, isoprene glycol, dipropylene glycol, diglycerin, and 1,2-pentanediol, according to any one of claims 1 to 3. Skin external preparation. 5. A carboxyvinyl polymer salt and / or an acrylic acid / methacrylic acid (C10-30) alkyl salt is further contained, wherein the carboxyvinyl polymer salt is contained.
The external preparation for skin according to any one of items. 6. The external preparation for skin according to any one of claims 1 to 5, which is for protecting the skin from an irritant. 7. The external preparation for skin according to any one of claims 1 to 6, which is a cosmetic. 8. The cosmetic according to claim 7, which is for sensitive skin.